BNF for Children 2011-2012

590 13.10.2 Antifungal preparations BNFC 2011–2012Oral and intestinal fungal infections section12.3.2Vaginal candidiasis section 7.2.2Miconazole (Non-proprietary)Cream, miconazole nitrate 2%, net price 20 g = £2.05,45 g = £1.97Dental prescribing on NHS Miconazole cream may beprescribedDaktarin c (Janssen)Cream, miconazole nitrate 2%, net price 30 g = £1.82Excipients include butylated hydroxyanisoleNYSTATINCautions see notes aboveSide-effects see notes aboveLicensed use licensed for use in children (age rangenot specified by manufacturer)Indication and doseSkin infections due to Candida spp. for dose, seepreparationOral fungal infections section 12.3.2Nystaform c (Typharm) ACream, nystatin 100 000 units/g, chlorhexidinehydrochloride 1%, net price 30 g = £2.62Excipients include benzyl alcohol, cetostearyl alcohol, polysorbate 60DoseApply 2–3 times daily continuing for 7 days after lesionshave healed.Breast-feeding manufacturer advises avoid—presentin milk, but less than 5% of the dose is absorbed aftertopical application of terbinafine; avoid application tomother’s chestSide-effects see notes aboveLicensed use not licensed for use in childrenIndication and doseFungal skin infectionsApply thinly 1–2 times daily for up to 1 week intinea pedis, 1–2 weeks in tinea corporis and tineacruris, 2 weeks in cutaneous candidiasis and pityriasisversicolor; review after 2 weeksSystemic therapy section 5.2.51Terbinafine (Non-proprietary) ACream, terbinafine hydrochloride 1%, net price 15 g =£5.10, 30 g = £2.691. Can be sold to the public for external use in children over 16years for the treatment of tinea pedis and tinea cruris as acream containing terbinafine hydrochloride max. 1% in apack containing max. 15 g; also for the treatment of tineapedis, tinea cruris, and tinea corporis as a spray containingterbinafine hydrochloride max. 1% in a pack containing max.30 mL or as a gel containing terbinafine hydrochloride max.1% in a pack containing max. 30 gLamisil c (Novartis Consumer Health) ACream, terbinafine hydrochloride 1%, net price 15 g =£4.86, 30 g = £8.76Excipients include benzyl alcohol, cetyl alcohol, polysorbate 60, stearylalcohol13 SkinSALICYLIC ACIDCautions avoid broken or inflammed skinSalicylate toxicity Salicylate toxicity can occur particularlyif applied on large areas of skinSide-effects see notes aboveIndication and doseFungal nail infections, particularly tineaChild 5–18 years apply twice daily and afterwashingNote Use with caution in child likely to suck affecteddigitsHyperkeratotic skin disorders section 13.5.2Acne vulgaris section 13.6.1Warts and calluses section 13.7Phytex c (Wynlit) UPaint, salicylic acid 1.46% (total combined), tannicacid 4.89% and boric acid 3.12% (as borotanniccomplex), in a vehicle containing alcohol and ethylacetate, net price 25 mL (with brush) = £2.81Excipients none as listed in section 13.1.3Note FlammableTERBINAFINECautions avoid contact with eyesPregnancy manufacturer advises use only if potentialbenefit outweighs risk—animal studies suggest noadverse effectsTIOCONAZOLECautions see notes above; also use with caution ifchild likely to suck affected digitsPregnancy manufacturer advises avoidSide-effects see notes above; also local oedema, dryskin, nail discoloration, periungual inflammation, nailpain, rash, exfoliationLicensed use licensed for use in children (age rangenot specified by manufacturer)Indication and doseFungal nail infectionsApply to nails and surrounding skin twice daily forup to 6 months (may be extended to 12 months)Trosyl c (Pfizer) ACutaneous solution, tioconazole 28%, net price12 mL (with applicator brush) = £27.38Excipients none as listed in section 13.1.3UNDECENOATESSide-effects see notes aboveLicensed use Monphytol c not licensed for use inchildren under 12 years; Mycota c licensed for usein children (age range not specified by manufacturer)Indication and doseSee under preparations