BNF for Children 2011-2012

612 14.4 Vaccines and antisera BNFC 2011–201214 Immunological products and vaccinesChild 3–13 years 0.5 mL (repeated after 4–6weeks in children who have not received seasonalinfluenza vaccine previously)Child 13–18 years 0.5 mL as a single doseInfluenza A(HINI)vSee under Celvapan c and Pandemrix c belowSeasonal influenza vaccinesInactivated Influenza Vaccine (Split Virion) AFluInjection, suspension of formaldehyde-inactivatedinfluenza virus (split virion) grown in fertilised hens’eggs, net price 0.25-mL prefilled syringe = £6.29, 0.5-mL prefilled syringe = £6.29Excipients may include neomycin and polymyxinAvailable from Sanofi PasteurContra-indications avoid preparations marketed by Pfizer,Wyeth, or CSL Biotherapies in child under 5 years—increased riskof febrile convulsionsInactivated Influenza Vaccine (Surface Antigen)AFlu or Flu(adj)Injection, suspension of propiolactone-inactivatedinfluenza virus (surface antigen) grown in fertilisedhens’ eggs, net price 0.5-mL prefilled syringe = £4.15Excipients may include neomycin, polymyxin B and traces of thiomersalAvailable from Novartis VaccinesAgrippal c (Novartis Vaccines) AInjection, suspension of formaldehyde-inactivatedinfluenza virus (surface antigen) grown in fertilisedhens’ eggs, net price 0.5-mL prefilled syringe = £5.85Excipients include kanamycin and neomycinBegrivac c (Novartis Vaccines) AInjection, suspension of formaldehyde-inactivatedinfluenza virus (split virion) grown in fertilised hens’eggs, net price 0.5-mL prefilled syringe = £5.85Excipients include polymyxin BEnzira c (Pfizer) AInjection, suspension of inactivated influenza virus(split virion) grown in fertilised hens’ eggs, net price0.5-mL prefilled syringe = £6.33Excipients include neomycin and polymyxin BContra-indications child under 5 years—increased risk of febrileconvulsionsFluarix c (GSK) AInjection, suspension of formaldehyde-inactivatedinfluenza virus (split virion) grown in fertilised hens’eggs, net price 0.5-mL prefilled syringe = £5.39Excipients include gentamicinFluvirin c (Novartis Vaccines) AInjection, suspension of formaldehyde-inactivatedinfluenza virus (surface antigen) grown in fertilisedhens’ eggs, net price 0.5 mL prefilled syringe = £5.55Excipients include neomycin, polymyxin B, and traces of thiomersalImuvac c (Abbott Healthcare) AInjection, suspension of formaldehyde-inactivatedinfluenza virus (surface antigen) grown in fertilisedhens’ eggs, net price 0.5-mL prefilled syringe = £6.59Excipients include gentamicinInfluvac Sub-unit c (Abbott Healthcare) AInjection, suspension of formaldehyde-inactivatedinfluenza virus (surface antigen) grown in fertilisedhens’ eggs, net price 0.5-mL prefilled syringe = £5.22Excipients include gentamicinMastaflu c (MASTA) AInjection, suspension of formaldehyde-inactivatedinfluenza virus (surface antigen) grown in fertilisedhens’ eggs, net price 0.5-mL prefilled syringe = £6.50Excipients include gentamicinViroflu c (Crucell) AInjection, suspension of inactivated influenza virus(surface antigen, virosome) grown in fertilised hens’eggs, net price 0.5-mL prefilled syringe = £6.33Excipients include neomycin and polymyxin BMonovalent influenza A(H1N1)v vaccinesCelvapan c (Baxter) TAInjection, suspension of formaldehyde-inactivatedinfluenza A(H1N1)v virus (whole virion, grown in verocells), 15 micrograms/mL, 5-mL multidose vial contains10 doses of 0.5 mLDosePrevention of influenza A(H1N1)v. By intramuscular injectionChild 6 months–18 years 2 doses each of 0.5 mLseparated by an interval of at least 3 weeksNote Celvapan c is not interchangeable withPandemrix cPandemrix c (GSK) TAInjection, suspension of inactivated influenzaA(H1N1)v virus (split virion, grown in fertilised hens’eggs) 7.5 micrograms/mL when mixed with emulsionof adjuvant, 5 mL of mixed multidose vial contains 10doses of 0.5 mLExcipients include gentamicin and thiomersalDosePrevention of influenza A(H1N1)v. By intramuscular injectionChild 6 months–10 years 0.25 mL as a single doseChild 10–18 years 0.5 mL as a single doseNote Pandemrix c is not interchangeable withCelvapan cMeasles vaccineMeasles vaccine has been replaced by a combined livemeasles, mumps and rubella vaccine (MMR vaccine).MMR vaccine may be used in the control of outbreaks ofmeasles (see under MMR Vaccine).Single antigen vaccineNo longer available in the UKCombined vaccinesSee MMR vaccine, belowMeasles, Mumps and Rubella (MMR)vaccineA combined live measles, mumps, and rubellavaccine (MMR vaccine) aims to eliminate measles,mumps and rubella (and congenital rubella syndrome).Every child should receive two doses of MMR vaccineby entry to primary school, unless there is a validcontra-indication (see section 14.1). MMR vaccineshould be given irrespective of previous measles,mumps, or rubella infection or vaccination.The first dose of MMR vaccine is given to children aged12–13 months. A second dose is given before starting