BNF for Children 2011-2012

BNFC 2011–2012 1.5.1 Aminosalicylates 51Asacol c MR (Warner Chilcott) ATablets, red, e/c, mesalazine 400 mg, net price 90-tabpack = £29.41, 120-tab pack = £39.21. Label: 5, 25,counselling, blood disorder symptoms (see recommendationabove)DoseAcute attack. By mouthChild 12–18 years 800 mg 3 times dailyMaintenance of remission of ulcerative colitis andCrohn’s ileo-colitis. By mouthChild 12–18 years 400–800 mg 2–3 times dailyNote Preparations that lower stool pH (e.g. lactulose) mayprevent release of mesalazineIpocol c (Sandoz) ATablets, e/c, mesalazine 400 mg, net price 120-tabpack = £41.62. Label: 5, 25, counselling, blood disordersymptoms (see recommendation above)DoseAcute attack. By mouthChild 12–18 years 800 mg 3 times dailyMaintenance of remission. By mouthChild 12–18 years 400–800 mg 3 times dailyMesren MR c (IVAX) ATablets, red-brown, e/c, mesalazine 400 mg, net price90-tab pack = £19.50, 120-tab pack = £26.00. Label: 5,25, counselling, blood disorder symptoms (seerecommendation above)DoseAcute attack. By mouthChild 12–18 years 800 mg 3 times dailyMaintenance of remission of ulcerative colitis andCrohn’s ileo-colitis. By mouthChild 12–18 years 400–800 mg 3 times dailyPentasa c (Ferring) ATablets, m/r, scored, mesalazine 500 mg (grey), netprice 100-tab pack = £24.21. Counselling, administration(see dose), blood disorder symptoms (seerecommendation above)DoseAcute attack. By mouthChild 5–15 years 15–20 mg/kg (max. 1 g) 3 times dailyChild 15–18 years 1–2 g twice daily; total daily dosemay alternatively be given in 3 divided dosesMaintenance of remission. By mouthChild 5–15 years 10 mg/kg (max. 500 mg) 2–3 timesdailyChild 15–18 years 2 g once dailyAdministration tablets may be halved, quartered, or dispersedin water, but should not be chewedGranules, m/r, pale grey-brown, mesalazine 1 g/sachet, net price 50-sachet pack = £28.82;2 g/sachet, 60-sachet pack = £72.05. Counselling,administration (see dose), blood disorder symptoms(see recommendation above)DoseAcute attack. By mouthChild 5–12 years 15–20 mg/kg (max. 1 g) 3 times dailyChild 12–18 years 1–2 g twice daily; total daily dosemay alternatively be given in 3–4 divided dosesMaintenance of remission. By mouthChild 5–12 years 10 mg/kg (max. 500 mg) 2–3 timesdailyChild 12–18 years 2 g once dailyAdministration contents of one sachet should be weighedand divided immediately before use; discard any remaininggranules. Granules should be placed on tongue and washeddown with water or orange juice without chewingRetention enema, mesalazine 1 g in 100-mL pack, netprice 7 enemas = £17.73. Counselling, blood disordersymptoms (see recommendation above)DoseAcute attack affecting the rectosigmoid region. By rectumChild 12–18 years 1 g at bedtimeSuppositories, mesalazine 1 g, net price 28-suppospack = £40.01. Counselling, blood disorder symptoms(see recommendation above)DoseAcute attack, ulcerative proctitis. By rectumChild 12–18 years 1 g daily for 2–4 weeksMaintenance, ulcerative proctitis. By rectumChild 12–18 years 1 g dailySalofalk c (Dr Falk) ATablets, e/c, yellow, mesalazine 250 mg, net price100-tab pack = £16.19; 500 mg, 100-tab pack =£32.38. Label: 5, 25, counselling, blood disordersymptoms (see recommendation above)DoseAcute attack. By mouthChild 6–18 years and body-weight under 40 kg 10–20 mg/kg 3 times dailyChild 6–18 years and body-weight over 40 kg 0.5–1 g3 times dailyMaintenance of remission. By mouthChild 6–18 years and body-weight under 40 kg 5–10 mg/kg 3 times daily; total daily dose may alternativelybe given in 2 divided dosesChild 6–18 years and body-weight over 40 kg 500 mg3 times dailyGranules, m/r, grey, e/c, vanilla-flavoured, mesalazine500 mg/sachet, net price 100-sachet pack =£28.74; 1 g/sachet, 50-sachet pack = £28.74; 1.5 g/sachet, 60-sachet pack = £48.85. Counselling,administration (see dose), blood disorder symptoms(see recommendation above)Excipients include aspartame (section 9.4.1)DoseAcute attack. By mouthChild 6–18 years and body-weight under 40 kg 10–20 mg/kg 3 times daily1 Gastro-intestinal system