BNF for Children 2011-2012

BNFC 2011–2012 4.6 Drugs used in nausea and vertigo 195that prolong QT interval); hypokalaemia; hypomagnesaemia;bradycardiaHepatic impairment max. 625 micrograms repeatedevery 6 hours as requiredRenal impairment max. 625 micrograms repeatedevery 6 hours as requiredPregnancy section 4.2.1Breast-feeding limited information available—avoidrepeated administrationSide-effects section 4.2.1; also anxiety, cardiac arrest,hallucinations, and inappropriate secretion of antidiuretichormoneIndication and dosePrevention and treatment of postoperativenausea and vomiting. By intravenous injectionChild 2–18 years 20–50 micrograms/kg (max.1.25 mg) 30 minutes before the end of surgery,repeated every 6 hours as necessaryXomolix c (ProStrakan) TAInjection, droperidol 2.5 mg/mL, net price 1-mL amp= £3.94PERPHENAZINECautions see notes in section 4.2.1Contra-indications see notes in section 4.2.1Hepatic impairment see notes in section 4.2.1Renal impairment see notes in section 4.2.1Pregnancy see notes in section 4.2.1Breast-feeding see notes in section 4.2.1Side-effects see Perphenazine, section 4.2.1Indication and doseSevere nausea and vomiting unresponsive toother antiemetics. By mouthChild 14–18 years 4 mg 3 times daily, adjustedaccording to response, max. 24 mg dailyPreparationsSection 4.2.1PROCHLORPERAZINECautions see notes in section 4.2.1; hypotension morelikely after intramuscular injectionContra-indications see notes in section 4.2.1Hepatic impairment see notes in section 4.2.1Renal impairment see notes in section 4.2.1Pregnancy see notes in section 4.2.1Breast-feeding see notes in section 4.2.1Side-effects see notes in section 4.2.1; respiratorydepression may occur in susceptible childrenLicensed use injection not licensed for use in childrenIndication and dosePrevention and treatment of nausea and vomiting. By mouthChild 1–12 years and over 10 kg 250 micrograms/kg2–3 times dailyChild 12–18 years 5–10 mg, repeated if necessaryup to 3 times daily. By intramuscular injectionChild 2–5 years, 1.25–2.5 mg, repeated if necessaryup to 3 times dailyChild 5–12 years 5–6.25 mg, repeated if necessaryup to 3 times dailyChild 12–18 years 12.5 mg, repeated if necessaryup to 3 times dailyNote Doses are expressed as prochlorperazine maleate ormesilate; 1 mg prochlorperazine maleate : 1 mg prochlorperazinemesilateProchlorperazine (Non-proprietary) ATablets, prochlorperazine maleate 5 mg, net price 28-tab pack = £1.25, 84-tab pack = £2.28. Label: 2Injection, prochlorperazine mesilate 12.5 mg/mL, netprice 1-mL amp = 52pStemetil c (Sanofi-Aventis) ATablets, prochlorperazine maleate 5 mg (off-white),net price 28-tab pack = £1.98, 84-tab pack = £5.94.Label: 2Syrup, straw-coloured, prochlorperazine mesilate5 mg/5 mL, net price 100-mL pack = £3.34. Label: 2Injection, prochlorperazine mesilate 12.5 mg/mL, netprice 1-mL amp = 52pBuccal preparationBuccastem c (Alliance) ATablets (buccal), pale yellow, prochlorperazine maleate3 mg, net price 5 10-tab pack = £5.89. Label: 2,counselling, administration, see under Dose belowDose. By mouthChild 12–18 years 1–2 tablets twice daily; tablets areplaced high between upper lip and gum and left todissolveTRIFLUOPERAZINECautions see notes in section 4.2.1Contra-indications see notes in section 4.2.1Hepatic impairment see notes in section 4.2.1Renal impairment see notes in section 4.2.1Pregnancy see notes in section 4.2.1Breast-feeding see notes in section 4.2.1Side-effects see Trifluoperazine section 4.2.1Indication and doseSevere nausea and vomiting unresponsive toother antiemetics. By mouthChild 3–5 years up to 500 micrograms twice dailyChild 6–12 years up to 2 mg twice dailyChild 12–18 years 1–2 mg twice daily; max. 3 mgtwice dailyPreparationsSection 4.2.1Domperidone and metoclopramideDOMPERIDONECautions children; interactions: Appendix 1 (domperidone)Contra-indications prolactinaemia; if increased gastro-intestinalmotility harmful4 Central nervous system