BNF for Children 2011-2012

BNFC 2011–2012 14.4 Vaccines and antisera 615onto aluminium phosphate, net price 0.5-mL prefilledsyringe = £7.50Dose. By intramuscular injectionChild 2 months–1 year for routine immunisation,0.5 mL, see notes above and Immunisation schedule,section 14.1Child 1–18 years 0.5 mL as a single doseNote Subcutaneous route used for children with bleedingdisordersAvailable as part of childhood immunisation schedule fromImmFormMenjugate Kit c (Sanofi Pasteur) AInjection, powder for reconstitution, capsular polysaccharideantigen of Neisseria meningitidis group C(conjugated to Corynebacterium diphtheriae protein),adsorbed onto aluminium hydroxide, single-dose vialsDose. By intramuscular injectionChild 2 months–1 year for routine immunisation,0.5 mL, see notes above and Immunisation schedule,section 14.1Child 1–18 years 0.5 mL as a single doseNote Subcutaneous route used for children with bleedingdisordersAvailable as part of childhood immunisation schedule fromImmFormNeisVac-C c (Baxter) AInjection, suspension of polysaccharide antigen ofNeisseria meningitidis group C (conjugated to tetanustoxoid protein), adsorbed onto aluminium hydroxide,0.5-mL prefilled syringeDose. By intramuscular injectionChild 2 months–1 year for routine immunisation,0.5 mL, see notes above and Immunisation schedule,section 14.1Child 1–18 years 0.5 mL as a single doseAvailable as part of childhood immunisation schedule fromImmFormMeningococcal Group C conjugate vaccine withHaemophilus Influenzae type B vaccineSee Haemophilus Influenzae type B vaccineMeningococcal A, C, W135, and Y conjugatevaccineMenveo c (Novartis Vaccines) TAInjection, powder for reconstitution, capsular oligosaccharideantigens of Neisseria meningitidis groupsA, C, W135, and Y (conjugated to Corynebacteriumdiphtheriae protein), net price single-dose vial (withsyringe containing diluent) = £40.01Dose. By intramuscular injection preferably into deltoidregionChild 3 months–1 year 2 doses of 0.5 mL separated byan interval of 1 monthChild 1–18 years 0.5 mL as a single doseMeningococcal polysaccharide A, C, W135 and YvaccineACWY Vax c (GSK) TAInjection, powder for reconstitution, capsular polysaccharideantigens of Neisseria meningitidis groupsA, C, W135 and Y, net price single-dose vial (withsyringe containing diluent) = £16.73Dose. By deep subcutaneous injectionChild 5–18 years 0.5 mL as a single dose; booster dosefor those at continued risk, 0.5mL 5 years after initialdoseMumps vaccineSingle antigen vaccineNo longer available in the UKCombined vaccinesSee MMR Vaccine, p. 612Pertussis vaccinePertussis vaccine is given as a combination preparationcontaining other vaccines (see Diphtheria Vaccines).Acellular vaccines are derived from highly purifiedcomponents of Bordetella pertussis. Primaryimmunisation against pertussis (whooping cough)requires 3 doses of an acellular pertussis-containingvaccine (see Immunisation schedule, section 14.1,p. 601), given at intervals of 1 month from the age of2 months.All children up to the age of 10 years should receiveprimary immunisation with diphtheria, tetanus, pertussis(acellular, component), poliomyelitis (inactivated)and haemophilus type b conjugate vaccine (adsorbed).A booster dose of an acellular pertussis-containingvaccine should ideally be given 3 years after the primarycourse, although, the interval can be reduced to 1 year ifthe primary course was delayed.Children aged 1–10 years who have not received apertussis-containing vaccine as part of their primaryimmunisation schedule should be offered 1 dose of asuitable pertussis-containing vaccine; after an interval ofat least 1 year, a booster dose of a suitable pertussiscontainingvaccine should be given. Immunisationagainst pertussis is not routinely recommended in individualsover 10 years of age.Contacts Vaccination against pertussis should beconsidered for close contacts of cases with pertussiswho have been offered antibacterial prophylaxis (Table2, section 5.1). Unimmunised or partially immunisedcontacts under 10 years of age should complete theirvaccination against pertussis. A booster dose of anacellular pertussis-containing vaccine is recommendedfor contacts aged 10–18 years who have not received apertussis-containing vaccine in the last 10 years andwho have not received adsorbed diphtheria [low dose],tetanus, and poliomyelitis (inactivated) vaccine in thelast month.Cautions Section 14.1Contra-indications Section 14.1Pregnancy see p. 600Breast-feeding see p. 60014 Immunological products and vaccines