BNF for Children 2011-2012

BNFC 2011–2012 Appendix 4: Intravenous infusions for neonatal intensive care 793Glyceryl trinitrate (p. 104)Dilute 3 mg/kg body-weight to a final volume of50 mL with Glucose 5% or Sodium Chloride 0.9%; anintravenous infusion rate of 1 mL/hour provides adose of 1 microgram/kg/minute; max. concentrationof 400 micrograms/mL (but concentration of 1 mg/mL has been used via a central venous catheter).Note Glass or polyethylene apparatus is preferable; loss ofpotency will occur if PVC is usedHeparin (as sodium) (p. 115)Maintenance of umbilical arterial catheter, dilute50 units to a final volume of 50 mL with SodiumChloride 0.45% or use ready-made bag containing500 units in 500 mL Sodium Chloride 0.9%; infuse at0.5 mL/hour.Treatment of thrombosis, dilute 1250 units/kg bodyweightto a final volume of 50 mL with Glucose 5% orSodium Chloride 0.9%; an intravenous infusion rate of1 mL/hour provides a dose of 25 units/kg/hourInsulin (soluble) (p. 352)Dilute 5 units to a final volume of 50 mL with SodiumChloride 0.9% and mix thoroughly; an intravenousinfusion rate of 0.1 mL/kg/hour provides a dose of0.01 units/kg/hour.Note Insulin may be absorbed by plastics, flush giving setwith 5 mL of infusion fluid containing insulinMidazolam (p. 234 and p. 638)Dilute 15 mg/kg body-weight to a final volume of50 mL with Glucose 5% or Sodium Chloride 0.9%; anintravenous infusion rate of 0.1 mL/hour provides adose of 30 micrograms/kg/hourIntravenous infusion information for neonatal intensivecare only; for information in other children, seeindividual drug monographs.Morphine sulphate (p. 207)Dilute 2.5 mg/kg body-weight to a final volume of50 mL with Glucose 5% or 10% or Sodium Chloride0.9%; an intravenous infusion rate of 0.1 mL/hourprovides a dose of 5 micrograms/kg/hourNoradrenaline/Norepinephrine (p. 113)Dilute 600 micrograms (base)/kg body-weight to afinal volume of 50 mL with Glucose 5% or SodiumChloride and Glucose; an intravenous infusion rate of0.1 mL/hour provides a dose of 20 nanograms (base)/kg/minute; infuse through central venous catheter;max. concentration of noradrenaline (base) 40 micrograms/mL(higher concentrations can be used iffluid restricted). Discard if discoloured. Incompatiblewith bicarbonate or alkaline solutions.Note 500 micrograms of noradrenaline base is equivalent to1 mg of acid tartrate. Dose expressed as the baseVecuronium (p. 645)Reconstitute each vial with 5 mL Water for Injectionsto give a 2 mg/mL solution. Dilute 5 mg/kg bodyweightto a final volume of 50 mL with Glucose 5% orSodium Chloride 0.9%; an intravenous infusion rate of0.5 mL/hour provides a dose of 50 micrograms/kg/hour; minimum concentration of 40 micrograms/mLAppendix 4: Intravenous infusions for neonatal intensive care