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Guidelines for ATC classification and DDD assignment - WHOCC

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C02 ANTIHYPERTENSIVES<br />

102<br />

See also C03 - Diuretics, C07 - Beta blocking agents, C08 - Calcium<br />

channel blockers <strong>and</strong> C09 - Agents acting on the renin-angiotensin<br />

system.<br />

Antihypertensives are mainly classified at 3rd levels according to the<br />

mechanism of action. Most headings are self-explanatory:<br />

C02A Antiadrenergic agents, centrally acting<br />

C02B Antiadrenergic agents, ganglion-blocking<br />

C02C Antiadrenergic agents, peripherally acting<br />

C02D Arteriolar smooth muscle, agents acting on<br />

C02K Other antihypertensives<br />

C02L Antihypertensives <strong>and</strong> diuretics in combination<br />

C02N Combinations of antihypertensives in <strong>ATC</strong> gr. C02<br />

The oral <strong>DDD</strong>s are based on the average doses needed to reduce the<br />

blood pressure to a normal level in patients with mild-moderate<br />

hypertension.<br />

Parenteral <strong>DDD</strong>s are based on dosages used <strong>for</strong> the treatment of<br />

hypertensive crises <strong>and</strong> are based on the content of the active<br />

ingredient pr. vial (ampoule).<br />

C02A ANTIADRENERGIC AGENTS, CENTRALLY ACTING<br />

C02AA Rauwolfia alkaloids<br />

This group comprises plain <strong>and</strong> combined rauwolfia preparations used<br />

in hypertension.<br />

There are separate 5th levels <strong>for</strong> combinations of rauwolfia alkaloids<br />

(C02AA03) <strong>and</strong> <strong>for</strong> rauwolfia, whole root (C02AA04).<br />

Combinations with beta blocking agents, see C07F - Beta blocking<br />

agents <strong>and</strong> other antihypertensives.<br />

Combinations with diuretics, see C02LA - Rauwolfia alkaloids <strong>and</strong><br />

diuretics in combination.

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