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Guidelines for ATC classification and DDD assignment - WHOCC

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106<br />

Diuretics in combination with angiotensin II antagonists are classified in<br />

C09DA.<br />

The need <strong>for</strong> a systematic approach to classify combinations of different<br />

antihypertensives has resulted in a ranking according to the <strong>ATC</strong> codes.<br />

Substances classified in <strong>ATC</strong> group C02AA take precedence over<br />

C02AB <strong>and</strong> substances in C02A take precedence over C02B etc.<br />

Example: A combined preparation containing bietaserpine, hydralazine<br />

<strong>and</strong> hydrochlorothiazide will be given the code C02LA07 according to<br />

the above mentioned ranking.<br />

Combinations with psycholeptics are classified at separate 5th levels<br />

using the corresponding 70-series.<br />

It has been considered most appropriate to assign fixed <strong>DDD</strong>s<br />

based on the average use of the different combinations without<br />

considering <strong>and</strong> comparing the strengths of the various<br />

components. 1 tablet is the fixed <strong>DDD</strong> <strong>for</strong> products given once<br />

daily whereas the fixed <strong>DDD</strong> <strong>for</strong> products given twice daily <strong>and</strong><br />

three times daily is respectively 2 tablets <strong>and</strong> 3 tablets. The<br />

assigned <strong>DDD</strong>s cannot always be compared with the <strong>DDD</strong>s<br />

assigned <strong>for</strong> plain preparations.<br />

C02LA Rauwolfia alkaloids <strong>and</strong> diuretics in combination<br />

C02LB Methyldopa <strong>and</strong> diuretics in combination<br />

C02LC Imidazoline receptor agonists in combination with diuretics<br />

C02LE Alpha-adrenoreceptor antagonists <strong>and</strong> diuretics<br />

C02LF Guanidine derivatives <strong>and</strong> diuretics<br />

C02LG Hydrazinophthalazine derivatives <strong>and</strong> diuretics<br />

C02LK Alkaloids, excl. rauwolfia, in combination with diuretics<br />

C02LL MAO inhibitors <strong>and</strong> diuretics<br />

C02LN Serotonin antagonists <strong>and</strong> diuretics

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