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COMPLEX STUDY OF PROTECTED, ENDEMIC AND RARE HIGH-MOUNTAIN MEDICINAL PLANTS FROM THE BULGARIAN FLORA –PRESERVATION AND SUSTAINABLE USEA. Vitkova 1 , D. Peev 1 , L. Evstatieva 1 , P. Yurukova 1 , M. Stanilova 1 , M. Nikolova 1 ,E. Jankova 1 , A. Gavrilova 1 , G. Baldziev 1 , R. Nikolaev 1 , N. Vuliovska 1 ,Tz. Tzvetanov 1 , E. Zayova 2 , M. Petrova 2 , M. Todorova 3 , A. Trendafilova 3 ,K. Alipieva 3 , J. Staneva 31 Institute of Botany, BAS, 1113 Sofia, Akad.G.Bonchev St. 23,E-mail: avitkova@bio.bas.bg; 2 Institute of Genetics, BAS, 1113 Sofia, Tzarigradroad – 13th km, E-mail: genetika@bas.bg; 3 Institute of Organic Chemistry withCentre of Phytochemistry, BAS, 1113 Sofia, Akad. G. Bonchev St. 9,Е-mail: todorova@orgchim.bas.bgConservation of medicinal plants is an important part of biodiversity conservationin Bulgaria. In 2009 in three institutes of Bulgarian Academy of Sciences started todevelop a multidisciplinary research project on the high-mountain, protectedendemic and rare medicinal plants of the Bulgarian flora, funded by NationalScience Fund. This project is oriented towards extension of the investigations ofthe biodiversity in Bulgaria through complex research on high-mountain valuablemedicinal plants (Alchemilla achtarowii Pawl., A. jumrukczalica Pawl., A. mollis(Buser) Rothm., Gentiana lutea L., Sideritis scardica Griseb., Arnica montana L.)– Bulgarian and Balkan endemics, rare critically endangered or endangered ofextinction species for the Bulgarian phytogenetic fund. Possibilities for theirsustainable use with conventional and modern biotechnological methods forsuccessful cultivation. These investigations enables revelation of the regularities inthe distribution of the species, evaluation of the level of their being endangered,eco-biological features. The studies are going to be conducted at a few levels ofbiological organisation: population/clone; individual(s); cellular and subcellularlevel. The methods that will be used refer besides to different scientific fields:ecological-biological, phytochemical, embryological, biotechnological, statisticalmethods. The expected results will give new knowledge on the biodiversity, thecondition of the populations, the abiotic and biotic factors impact on the growth ofthe investigated high-mountain medicinal plants within their natural habitats.Information will be received on the possibilities and ways of the cultivation of theinvestigated species, and their sustainable use. The plant biodiversity of Bulgariaand Europe will be maintained, by preserving the genfund of economicallyvaluable endemic, rare, critically endangered and endangered high-mountainmedicinal plants. The authors are grateful for the financial support rendered by theNational Science Fund (Grant – DTK 02/38).104