IN T E L L E C T U S 2 /2 0 1 3 - agepi

ABSTRACT
Asthma and allergic rhinitis prevalence levels are
constantly growing worldwide, being influenced
by the genetic background, environmental factors
and their interaction. Allergic rhinitis in asthma patients
increases up to 50% asthma hospitalization
rates among adults and up to 25% among children.
Given the coexistence of these allergic disorders
an integrated management is recommended. The
innovative method is based on the results of the
case-control study that included 180 children and
aimed to assess genetic and environmental risk
factors and their interaction within the etiological
mechanisms of allergic diseases in autochthon children.
The mathematical predictive model revealed
the following risk factors: presence of the heterozygous
genotype with one allele functionally compromised
(CC16 G/A) of the CC16 38 G>A gene polymorphism;
onset of asthma by the age of 3 years;
presence of molds in the house environment; family
history of allergy in mother and/or father; and
complicated evolution of pregnancy and/or birth.
The proposed method will raise the efficiency of
secondary and tertiary preventive measures taken
for high-risk groups of children.
Keywords: asthma, allergic rhinitis, child, risk
factor, CC16 gene, polymorphism, predictive model
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SCIENTIFIC COMMUNICATIONS
Intellectus 2/2013 | 111