My PhD dissertation - Institut Fresnel

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Nom Maurin Prénom Michaël 129 Curriculum Vitae Date de Naissance 27 Juin 1976 Lieu de Naissance Thiais, France Nationalité Française Etat Civil Célibataire ETUDES 1987 – 1991 Collège à Thiais, France. 1991 – 1994 Lycée à Thiais, France. Obtention du Baccalauréat série C (Scientifique). 1994 – 1996 Préparation au Concours National Vétérinaire, Paris, France. 1996 – 2000 Etudes de chimie à l'Université Paris XI, Orsay, France. 2000 – 2001 Stage de D.E.A. à l'<strong>Institut</strong> Curie, Orsay, France, sous la responsabilité du Dr David Grierson: "Synthèse de Nouveaux Fluorophores Utilisables dans la Technologie des Puces à ADN". Juin 2001 Diplôme d'Etude Approfondies (D.E.A.) en Chimie Organique, Université Paris XI, Orsay, France. Octobre 2001 Début d'un travail de doctorat à l'Ecole Polytechnique Fédérale de Lausanne sous la responsabilité du Professeur Manfred Schlosser; Assistant responsable de la surveillance des travaux pratiques de chimie du 6 ème semestre.
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Various Facets of Organophosphorus
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III Remerciements Je tiens à remer
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3.3.6 Relevance of the Data Assesse
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VII Literature References 115 Compo
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IX Version Abrégée Les composés
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1 Introduction 1 The present thesis
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3 research groups in the field are
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5 However, this mechanism suffers f
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7 At first, a double bromine/lithiu
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10 Although the most frequently emp
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12 The preparation of the latter ph
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protected to its dioxolane derivati
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N (S)-14 1) NBS, THF, - 75 °C 2) -
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3 Alkaline Decomposition of Phospho
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3.2 Alkyl Carbanions Stabilities in
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3.3.1 Mechanistic Discussion on the
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25 The assumption reported by these
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27 However, in the eventuality of a
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29 To prepare tertiary phosphines b
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31 Table 4. Mixed tertiary alkylpho
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33 were comparable to those obtaine
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35 led to the formation of di-tert-
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37 depending on the alkyl substitue
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39 4 A Novel Access to Atropisomeri
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41 Since the homocoupling of the ha
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43 Few other attempts to selectivel
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45 The second phenol ether 36 was f
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47 The enantiomeric purity was chec
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49 A second purpose of this derivat
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51 substrates considered. In conseq
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53 Single-crystal X-ray analysis of
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55 To convert atropisomer Ia into I
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57 This finally allows one to use t
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the steric bulk and charge delocali
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61 To check the reproducibility of
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63 Figure 9. Full lineshape analysi
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66 suitably substituted dilithiobip
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Experimental Part
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70 deuterochloroform (CDCl3) unless
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72 1 H NMR: δ = 7.32 (dddd, J = 9,
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1 H NMR: δ = 6.96 (s, 3 H), 6.94 (
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76 C21H21O9P (448.36) calcd. C 56.2
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78 C12H12BrN (250.13) calcd. C 57.6
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80 C13H13NO2 (215.25) calcd. C 72.5
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82 3.1.1 Dialkyl-N,N-diethylaminoph
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84 apparatus. The solution was adde
Page 108 and 109: 86 Di-tert-butylisopropylphosphine
Page 110 and 111: 88 13 C NMR: δ = 32.9 (d, J = 12 H
Page 112 and 113: 90 13 C NMR: δ = 41.5 (d, J = 61 H
Page 114 and 115: 31 P NMR: δ = 53.4 ppm. 92 C16H31O
Page 116 and 117: 94 13 C NMR: δ = 40.8 (d, J = 3 Hz
Page 118 and 119: 96 31 P NMR settings: It is known t
Page 120 and 121: 98 Theoretical ratio: (96.1:3.9) Ex
Page 123 and 124: 101 4 The Preparation and Racemate
Page 125 and 126: 103 extraction protocol with ethyl
Page 127 and 128: 105 extracted with ethyl acetate (2
Page 129 and 130: 107 (+)-(M)-Dimethyl-6,6’-dibromo
Page 131 and 132: 109 (+)-(M)-2,2’-Dibromo-6,6’-b
Page 133 and 134: 111 1 H NMR: δ = 7.2 (m, 20 H), 7.
Page 135 and 136: 113 2,2’-Dilithio-6,6’-bis(meth
Page 137: References
Page 140 and 141: 116 Conference Proceedings, Naples,
Page 142 and 143: 118 [ 70] J. Drowart, C.E. Myers, R
Page 144 and 145: 120 [117] S.T. Graul, R.R. Squires,
Page 146 and 147: 122 [170] B.H. Lipshutz, F. Kayser,
Page 148: 124 [212] M. Schlosser, in Organome
Page 152: O P 27i: p. 30, 80 C 9H 21OP P 26b:
Page 156: P P P O 2: p. 11, 59 3 P O O O 11:
Page 162: 130 Publication F. Leroux, M. Mauri
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My PhD dissertation - Institut Fresnel

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