of the Max - MDC
of the Max - MDC
of the Max - MDC
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Structure <strong>of</strong> <strong>the</strong> Group<br />
Group Leader<br />
Pr<strong>of</strong>. Dr. Achim Leutz<br />
Scientists<br />
Dr. Valerie Begay<br />
Dr. Elisabeth Kowenz-Leutz<br />
Dr. Jörn Lausen<br />
Dr. Marina Scheller<br />
Dr. Jeske Smink<br />
Dr. Klaus Wethmar<br />
Graduate Students<br />
Ole Pless<br />
Katrin Zaragoza<br />
Technical Assistants<br />
Maria Knoblich<br />
Christiane Calließ<br />
Karolin Friedrich*<br />
Anne Viktoria Giese*<br />
Petra Gosten-Heinrich<br />
Secretariat<br />
Sylvia Sibilak<br />
* part <strong>of</strong> <strong>the</strong> period reported<br />
Figure 2. Atypical hematopoietic stem cells following β-catenin activation.<br />
Left: Morphology <strong>of</strong> cells isolated from bone marrow after activation β-catenin (cytospins, May-Grünwald-Giemsa staining, original magnification,<br />
x630). Right: Bone marrow colonies contain high numbers <strong>of</strong> blasts and immature myeloid precursors after activation β-catenin.<br />
Colonies were grown in semi-liquid culture medium with a mix <strong>of</strong> cytokines (7 days, May-Grünwald-Giemsa staining, original magnification,<br />
x630).<br />
Selected Publications<br />
Mo X., Kowenz-Leutz E, Xu H, Leutz A. (2004) Ras induces<br />
mediator complex exchange on C/EBPβ. Molecular Cell, 13:<br />
241-250<br />
Begay, V, Smink, J, and Leutz, A. (2004). Essential requirement<br />
<strong>of</strong> CCAAT/enhancer binding proteins in embryogenesis.<br />
Molecular Cell Biol, 24, 9744-9751<br />
Jundt, F, Raetzel, N, Muller, C, Calkhoven, CF, Kley, K., Mathas,<br />
S, Lietz, A, Leutz, A, and Dörken, B. (2005). A rapamycin derivative<br />
(everolimus) controls proliferation through down-regulation<br />
<strong>of</strong> truncated CCAAT enhancer binding protein b and NFkB<br />
activity in Hodgkin and anaplastic large cell lymphomas. Blood,<br />
106: 1801-7<br />
Mo, X, Kowenz-Leutz, E, Laumonnier, Y, Xu, H, and Leutz, A<br />
(2005) Histone H3-tail positioning and acetylation by c-Myb but<br />
not <strong>the</strong> v-Myb DNA binding SANT Domain. Genes & Development,<br />
19: 2447-2457<br />
Scheller, M, Huelsken, J, Rosenbauer, F, Taketo, MM,<br />
Birchmeier, W, Tenen, GD and Leutz, A. (2006). Hematopoietic<br />
stem cell and multi lineage defects by β-catenin activation.<br />
Nature Immunology, 7:1037-1047<br />
Wiesenthal, V, Leutz, A, and Calkhoven, CF, (2006) Analysis <strong>of</strong><br />
translation initiation using a translation control reporter<br />
system. Nature Protocols, 1: 1531-1537<br />
Cancer Research 91
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