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Infrastructure and administration/ Infrastruktur und Verwaltung Special work (training)/ Sonderaufgaben 21,8% 31% Cancer Research/Krebsforschung Technology transfer/Technologietransfer Independent Research/ Programmungebundene Forschung Comparative Genomics/Vergleichende Genomforschung Function and dysfunction of the nervous system/ Funktion und Dysfunktion des Nervensystems 1,3% 0,2% 0,3% 3% 14,3% 28% Cardiovascular and metabolic diseases/ Herz- Kreislauf- und Stoffwechselerkrankungen Extramural funding in 2006 (in thousands of €) / Drittmittelfinanzierung 2006 in T € Extramural funds / Drittmittelgeber Amounts / Drittmittelerlöse German Research Foundation/ Deutsche Forschungsgemeinschaft 4.035 EU/EU 2.909 Industry and other organizations/Industrie und sonstige Organisationen 2.694 Federal Ministry of Education and Research/ Bundesministerium für Bildung und Forschung (BMBF) 2.651 State of Berlin/Land Berlin 260 Total / Gesamt 12.549 State of Berlin/Land Berlin 2% German Research Foundation/ Deutsche Forschungsgemeinschaft 33% Industry and other organizations/ Industrie und sonstige Organisationen 21% 23% EU/EU 21% Federal Ministry of Education and Research/ Bundesministerium für Bildung und Forschung (BMBF) 222 Overview
Collaborative Research Centres (SFB) and Transregional Research Centres (TRR) of the German Research Foundation (DFG) SFB 507 The importance of non-neuronal cells with neurological disorders SFB 577 Molecular foundations of the clinical variability of monogenic diseases SFB 594 Molecular machines in protein folding and protein transport SFB 618 Theoretical biology: Robustness, modularity and evolutionary design of living systems SFB 633 Induction and modulation of T cell-imparted immunoreactions in the gastrointestinal tract SFB 650 Cellular approaches to the suppression of undesirable immunoreactions SFB 665 Development disorders in the nervous system TRR 19 Inflammatory myocardiopathy – molecular pathogen and treatment SFB 740 From Molecules to Modules: Organisation and Dynamics of Functional Units in Cells TRR 36 Principles and Applications of Adoptive T Cell Therapy Sonderforschungsbereiche (SFB) und Transregios (TRR) der Deutschen Forschungsgemeinschaft (DFG) SFB 507 Die Bedeutung nicht-neuronaler Zellen bei neurologischen Erkrankungen SFB 577 Molekulare Grundlagen klinischer Variabilität monogen bedingter Krankheiten SFB 594 Molekulare Maschinen in Proteinfaltung und Proteintransport SFB 618 Theor. Biologie: Robustheit, Modularität und evolutionäres Design lebender Systeme SFB 633 Induktion und Modulation T-zellvermittelter Immunreaktionen im Gastrointestinaltrakt SFB 650 Zelluläre Ansätze zur Suppression unerwünschter Immunreaktionen SFB 665 Entwicklungsstörungen im Nervensystem TRR 19 Inflammatorische Kardiomyopathie – Molekulare Pathogenese und Therapie SFB 740 Von Molekülen zu Modulen: Organisation und Dynamik zellulärer Funktionseinheiten TRR 36 Grundlagen und Anwendung adoptiver T-Zelltherapie National Genome Research Network (NGFN-2) Projects Genome network cardiovascular diseases: Comparative genomics of left ventricular hypertrophy and dysfunction in hypertension Genome network cardiovascular diseases: Functional genomics of cardiac damage in hypertension Genome network cardiovascular diseases: Prevalence of titin mutations and identification of new disease genes in patients with familial DCM Genome network CancerNet: Organ specificity of colorectal cancer metastasis Genome network NeuroNet: Moleculargenetic identification of disposing gene configurations with genetically determined epilepsies Genome network NeuroNet: CNS hyperexcitability in mouse models affecting ion transport diseases Systematic-methodological platform “GEM”: Genome-wide coupling analysis and association studies with then 10K and 100K Chips Systematic-methodological platform “DNA”, SNP Map Rat; MDC, Berlin, Systematic-methodological platform “DNA”, TP12.1(2): SNP Map – National genotyping platform Systematic-methodological platform “Protein”: Verification and identification of protein-protein interactions and systematic analysis of target proteins by means of X-ray structural analysis, TP 7 – Structure determination Systematic-methodological platform “Protein”: Verification and identification of proteinprotein interactions and systematic analysis of target proteins by means of X-ray structural analysis, TP 20 – Project management Systematic-methodological platform “Protein”: Verification and identification of protein-protein interactions and systematic analysis of target proteins by means of X-ray structural analysis, TP 8 Yeast two-hybrid protein interaction networks Systematic-methodological platform “Protein”: Verification and identification of protein-protein interactions and systematic analysis of target proteins by means of X-ray structural analysis, TP 1.1. Subcloning of ORFs Explorative project: Determining the genes on which the Williams-Beuren syndrome is based through the generation of an allelic series of mutations with the help of innovative transposon approaches, TP1 Projekte im Nationalen Genomforschungsnetz (NGFN 2) Genomnetz Herz-Kreislauf: Vergleichende Genomik der linksventrikulären Hypertropie und Dysfunktion bei Hypertonie Genomnetz Herz-Kreislauf: Funktionelle Genomik der kardialen Schädigung bei Hypertonie Genomnetz Herz-Kreislauf: Prävalenz von Titin-Mutationen und Identifizierung neuer Krankheitsgene in Patienten mit Familiärer Dilativer Kardiomyopathie Genomnetz Krebs: Organspezifität von Metastasen kolorektaler Tumoren Genomnetz Neuro: Molekulargenetische Identifizierung von disponierenden Genkonfigurationen bei genetisch determinierten Epilepsien Genomnetz Neuro: Systematische Genidentifikation und funktionelle Analysen bei häufigen neurologischen Erkrankungen Systematisch-methodische Plattform “GEM”: Genomweite Kopplungsanalyse und Assoziationsstudien mit den 10K und 100K Chips Systematisch-Methodische Plattform “DNA”: SNP MapRat, Standort MDC, Berlin Systematisch-Methodische Plattform “DNA”: SNP Nationale Genotypisierungsplattform Systematisch-Methodische Plattform “Protein”: Verifikation und Identifikation von Protein-Protein Interaktionen und systematische Analyse von Targetproteinen mittels Röntgenstrukturanalyse, TP 7 – Structure determination Systematisch-Methodische Plattform “Protein”: Verifikation und Identifikation von Protein-Protein Interaktionen und systematische Analyse von Targetproteinen mittels Röntgenstrukturanalyse, TP 20 – Project management Systematisch-Methodische Plattform “Protein”: Verifikation und Identifikation von Protein-Protein Interaktionen und systematische Analyse von Targetproteinen mittels Röntgenstrukturanalyse, TP 8 Yeast two-hybrid protein interaction networks Systematisch-Methodische Plattform “Protein”: Standort MDC Berlin: Verifikation und Identifikation und systematische Analyse von Targetproteinen mittels Röntgenstrukturanalyse”, TP 1.1. Umklonierung von full-length ORF’s und cDNA-Fragmenten in Expressions-Plasmide Explorative Projekte: Bestimmung der Gene, die dem Williams-Beuren Syndrom zugrunde liegen, durch die Generation einer allelischen Serie von Mutationen mit Hilfe von neuartigen Transposon Ansätzen, TP1 Overview 223
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Research Report 2008 MDC Berlin-Buc
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Research Report 2008 (covers the pe
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Cell Polarity and Epithelial Morpho
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Molecular Cell Biology and Gene The
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Foreword Vorwort As this book was b
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which survey the quality of protein
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Two major grants from the Helmholtz
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Cardiovascular and Metabolic Diseas
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ing on this topic have made importa
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explain why a certain gene or seque
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Figure 2. Uptake of lipoprotein (A)
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Molecular Mechanisms in Embryonic F
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Cardiovascular Hormones Michael Bad
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Angiogenesis and Cardiovascular Pat
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Hypertension, Vascular Disease, Gen
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Structure of the Group Group Leader
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eceptors did not change. Thus, syst
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Mechanisms of Hypertensioninduced T
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Differentiation and Regeneration of
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Heart Diseases Coordinator: Ludwig
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Figure 1. 3D-model of the actomyosi
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Cell Polarity and Epithelial Morpho
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Molecular and Cell Biology of the (
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number of circulating antibodies to
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Genetics, Genomics, Bioinformatics,
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Physiology and Pathology of Ion Tra
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Technical Assistants Alexander Fast
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Cancer Research Krebsforschung Coor
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how they infiltrate surrounding tis
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(Photo: David Ausserhofer/Copyright
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degradation (ERAD) pathway. In the
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Structural and Functional Genomics
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ated with the deregulation of cell
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A B C Only functional Met keratinoc
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I) Conditional ablation of the Bmp
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Genetics of Tumor Progression and M
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Signaling Mechanisms in Embryonic S
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Surgical Oncology Peter M. Schlag O
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Structure bition of differentiation
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such as self-renewal and differenti
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Signal Transduction in Tumor Cells
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Control of DNA Replication Manfred
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Nuclear Signalling and Chromosomal
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a. b. Figure 1. The Sleeping Beauty
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Structural and Functional Genomics
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A B Figure 2. Palmitoylation of the
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RNA Chemistry Eckart Matthes Hydrox
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Structure and Membrane Interaction
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Tumor Immunology Coordinator: Marti
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Formation of segregated ectopic fol
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Regulatory Mechanisms of Lymphocyte
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Biology and Targeted Therapy of Lym
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A Figure 1. Function of BH3-only pr
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Molecular Immunotherapy Antonio Pez
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Molecular Immunology and Gene Thera
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Molecular Cell Biology and Gene The
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A B C D CD39+ Treg cells and multip
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Experimental Pharmacology Iduna Fic
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Function and Dysfunction of the Ner
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(Photo: Dr. Hagen Wende, Research G
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tion of proteins causes human neuro
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- Pathophysiological Mechanisms of
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Stucture of the Group Group Leader
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What are the physiological features
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Visualization of the UniHi interact
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Dagmar Ehrnhöfer* Manuela Jacob* M
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Page 191 and 192: Neuronal Stem Cells Gerd Kempermann
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Page 231 and 232: Prof. Dr. Gary R. Lewin MDC Berlin-
Page 233 and 234: Dr. Thomas Müller Prof. Dr. Claus
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Page 241 and 242: MDC MAX-DELBRÜCK-CENTRUM FÜR MOLE
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