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Cancer, Stem Cells, and Transcription Factors Frank Rosenbauer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 92-94 Signal Transduction in Tumor Cells Claus Scheidereit . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 95-97 Intracellular Proteolysis Thomas Sommer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 98-99 Regulation of Nuclear Transport Processes Katrin Stade (Helmholtz Fellow) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 100 Control of DNA Replication Manfred Gossen . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 101-102 Nuclear Signalling and Chromosome Structure Harald Saumweber. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 103-105 Transposition Zoltán Ivics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 106-108 Structural and Functional Genomics Coordinator: Udo Heinemann Macromolecular Structure and Interaction Udo Heinemann . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 109-112 RNA Chemistry Eckart Matthes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 113-114 Structure and Membrane Interaction of G-proteins Oliver Daumke (Helmholtz Fellow) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 115-116 Tumor Immunology Coordinator: Martin Lipp Differentiation and Growth Control in Lymphocyte Development and Immunopathogenesis Martin Lipp. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 117-120 Regulatory Mechanisms of Lymphocyte Trafficking in Homeostasis and Immunopathogenesis Uta E. Höpken (Helmholtz Fellow). . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 121-122 Biology and Targeted Therapy of Lymphoma Bernd Dörken . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 123-125 Molecular Mechanisms of Immune Evasion in Tumor Biology and Herpesvirus Infection Armin Rehm (Helmholtz Fellow) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 126-127 Cancer Genetics and Cellular Stress Responses in Pathogenesis and Treatment of Lymphatic Malignancies Clemens A. Schmitt . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 128-129 Clinical and Molecular Oncology Peter Daniel . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 130-132 Molecular Immunotherapy Antonio Pezzutto . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 133-134 Molecular Immunology and Gene Therapy Thomas Blankenstein. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 135-136 IV Content
Molecular Cell Biology and Gene Therapy Wolfgang Uckert . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 137-139 Cellular Immunology of Autoimmune Reactions – Controlling the Balance between Effector and Suppressor T Cells Kirsten Falk/Olaf Rötzschke . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 140-142 Experimental Pharmacology Iduna Fichtner . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 143-145 Bioethics and Science Communication Christof Tannert . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 146 Function and Dysfunction of the Nervous System Funktion und Dysfunktion des Nervensystems. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 147-151 Coordinators: Carmen Birchmeier and Helmut Kettenmann Pathophysiological Mechanisms of Neurological and Psychiatric Disorders Imaging of the Living Brain Signalling Pathways in the Nervous System Signal Transduction/Developmental Biology Carmen Birchmeier . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 152-155 Molecular Control of Central and Peripheral Nervous System Development Stefan Britsch (Helmholtz Fellow). . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 156-157 Genetic Analysis of Neural Circuits Alistair N. Garratt (Helmholtz Fellow) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 158-159 Cellular Neurosciences Helmut Kettenmann. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 160-163 Proteomics and Molecular Mechanisms of Neurodegenerative Disorders Erich Wanker . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 164-167 Aging-related Protein Misfolding and Detoxification Mechanisms Jan Bieschke (Helmholtz Fellow). . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 168-169 Neuronal Connectivity Fritz G. Rathjen . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 170-172 Molecular Physiology of Somatic Sensation Gary R. Lewin . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 173-174 Mitochondrial Dynamics Christiane Alexander . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 175-176 Neuronal Stem Cells Gerd Kempermann . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 177-178 Targeting Ion Channel Function Ines Ibañez-Tallon . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 179-180 Content V
Page 1 and 2: Research Report 2008 MDC Berlin-Buc
Page 3 and 4: Research Report 2008 (covers the pe
Page 5: Cell Polarity and Epithelial Morpho
Page 9 and 10: Foreword Vorwort As this book was b
Page 11 and 12: which survey the quality of protein
Page 13 and 14: Two major grants from the Helmholtz
Page 15 and 16: Cardiovascular and Metabolic Diseas
Page 17 and 18: ing on this topic have made importa
Page 19 and 20: explain why a certain gene or seque
Page 21 and 22: Figure 2. Uptake of lipoprotein (A)
Page 23 and 24: Molecular Mechanisms in Embryonic F
Page 25 and 26: Cardiovascular Hormones Michael Bad
Page 27 and 28: Angiogenesis and Cardiovascular Pat
Page 29 and 30: Hypertension, Vascular Disease, Gen
Page 31 and 32: Structure of the Group Group Leader
Page 35 and 36: eceptors did not change. Thus, syst
Page 37 and 38: Mechanisms of Hypertensioninduced T
Page 39 and 40: Differentiation and Regeneration of
Page 41 and 42: Heart Diseases Coordinator: Ludwig
Page 53 and 54: Figure 1. 3D-model of the actomyosi
Page 55 and 56: Cell Polarity and Epithelial Morpho
Page 57 and 58:
Molecular and Cell Biology of the (
Page 59 and 60:
Structure of the Group Group Leader
Page 61 and 62:
Page 63 and 64:
number of circulating antibodies to
Page 65 and 66:
Genetics, Genomics, Bioinformatics,
Page 67 and 68:
Physiology and Pathology of Ion Tra
Page 69 and 70:
Technical Assistants Alexander Fast
Page 71 and 72:
Page 73 and 74:
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Page 77 and 78:
Page 79 and 80:
Cancer Research Krebsforschung Coor
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how they infiltrate surrounding tis
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(Photo: David Ausserhofer/Copyright
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degradation (ERAD) pathway. In the
Page 87 and 88:
Structural and Functional Genomics
Page 89 and 90:
ated with the deregulation of cell
Page 91 and 92:
A B C Only functional Met keratinoc
Page 93 and 94:
I) Conditional ablation of the Bmp
Page 95 and 96:
Genetics of Tumor Progression and M
Page 97 and 98:
Signaling Mechanisms in Embryonic S
Page 99 and 100:
Surgical Oncology Peter M. Schlag O
Page 101 and 102:
Page 103 and 104:
Structure bition of differentiation
Page 105 and 106:
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such as self-renewal and differenti
Page 109 and 110:
Signal Transduction in Tumor Cells
Page 111 and 112:
Page 113 and 114:
Page 115 and 116:
Control of DNA Replication Manfred
Page 117 and 118:
Nuclear Signalling and Chromosomal
Page 119 and 120:
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a. b. Figure 1. The Sleeping Beauty
Page 123 and 124:
Structural and Functional Genomics
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A B Figure 2. Palmitoylation of the
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RNA Chemistry Eckart Matthes Hydrox
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Structure and Membrane Interaction
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Tumor Immunology Coordinator: Marti
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Formation of segregated ectopic fol
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Regulatory Mechanisms of Lymphocyte
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Biology and Targeted Therapy of Lym
Page 139 and 140:
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A Figure 1. Function of BH3-only pr
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Molecular Immunotherapy Antonio Pez
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Molecular Immunology and Gene Thera
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Molecular Cell Biology and Gene The
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A B C D CD39+ Treg cells and multip
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Experimental Pharmacology Iduna Fic
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Function and Dysfunction of the Ner
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(Photo: Dr. Hagen Wende, Research G
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tion of proteins causes human neuro
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- Pathophysiological Mechanisms of
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Stucture of the Group Group Leader
Page 173 and 174:
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What are the physiological features
Page 177 and 178:
Page 179 and 180:
Visualization of the UniHi interact
Page 181 and 182:
Dagmar Ehrnhöfer* Manuela Jacob* M
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Page 185 and 186:
Lack of axonal bifurcation within t
Page 187 and 188:
Molecular Physiology of Somatic Sen
Page 189 and 190:
Mitochondrial Dynamics Christiane A
Page 191 and 192:
Neuronal Stem Cells Gerd Kempermann
Page 193 and 194:
Targeting Ion Channel Function Ines
Page 195 and 196:
RNA Editing and Hyperexcitability D
Page 197 and 198:
Molecular Neurology Frauke Zipp T h
Page 199 and 200:
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Academics Akademische Aktivitäten
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Charité-Universitätsmedizin Berli
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Helmholtz Fellows Helmholtz-Stipend
Page 207 and 208:
(Photo: Cécile Otten, Research Gro
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2007 19. January Neujahrsempfang de
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Speaker Institute Titel of Seminar
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Page 215 and 216:
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Overview Überblick
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erzielen, brauchen wir neue gemeins
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The Clinical Research Center (CRC)
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y such scientists in conjunction wi
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Zudem bietet das ECRC-Modell eine h
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(Photo: David Ausserhofer/ Copyrigh
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Business School” addressed challe
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Prof. Dr. Gary R. Lewin MDC Berlin-
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Dr. Thomas Müller Prof. Dr. Claus
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Type of Financing/Art der Finanzier
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Collaborative Research Centres (SFB
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Figures for technology transfer/Ken
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MDC MAX-DELBRÜCK-CENTRUM FÜR MOLE
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Buschow, Christian . . . . . . . .
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Herrmann, Ina . . . . . . . . . . .
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Mensen, Angela . . . . . . . . . .
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Schwarzer, Rolf . . . . . . . . . .
Page 251 and 252:
Campus Map Campusplan Robert-Rössl
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