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The end of 2007 brought another opportunity to reflect on future directions as we submitted three applications for “Project-Oriented Funding” to the Helmholtz Association. This is the main mechanism by which the MDC obtains funding. Thomas Willnow coordinated an application in our main research area of “Cardiovascular and Metabolic Diseases”, which involves groups from the DKFZ and GSF. MDC groups submitted proposals within the thematic areas of Cancer (an application organized by the DKFZ) and Neurodegenerative Diseases (organized by the Research Centre Jülich). Scientific reviews of the proposals will be carried out in early 2008. The real measure of an institute such as the MDC is the quality of its scientific work, and that is the subject of this book. This report comes at a very stimulating, vigorous moment in our campus’ history. Please regard this overview of our laboratories’ activities as an invitation to visit Berlin-Buch and take a deeper look. Walter Birchmeier Scientific Director Signaling in Development and Disease”, von Thomas Holstein von der Universität Heidelberg und mir selbst organisiert, führte insgesamt 350 Teilnehmer zusammen, darunter über dreißig der weltweit führenden Experten auf den Gebieten Entwicklung, Zellbiologie und Krebsforschung. Zusätzlich nahmen über zweihundert Wissenschaftler an einer von Thomas Sommer organisierten externen Veranstaltung in Italien teil, der EMBO-Konferenz über „Ubiquitin and Ubiquitin-like modifiers in cellular regulation”. Das Jahresende 2007 brachte eine weitere Gelegenheit, über künftige Richtungen nachzudenken, indem wir drei Anträge für projektorientierte Förderung an die Helmholtz-Gemeinschaft einreichten. Dies ist der Hauptweg, auf dem das MDC seine Finanzierung erhält. Thomas Willnow koordinierte einen Antrag auf unserem Hauptforschungsgebiet Herz- Kreislauf und Stoffwechsel-Krankheiten. Dieser Antrag schließt Gruppen vom DKFZ und von der GSF mit ein. Forschungsgruppen vom MDC reichten Anträge aus den Forschungsbereichen Krebs (ein vom DKFZ organisierter Antrag) und Neurodegenerative Krankheiten (vom Forschungszentrum Jülich organisiert) ein. Die wissenschaftliche Begutachtung dieser eingereichten Anträge wird zu Beginn des Jahres 2008 stattfinden. Der Maßstab, an dem ein Institut wie das MDC gemessen wird, ist die Qualität ihrer wissenschaftlichen Arbeit. Sie ist Gegenstand dieses Buches. Dieser Bericht erscheint zu einer Zeit intensiver Dynamik auf unserem Campus, getragen von hochmotivierten Mitarbeiterinnen und Mitarbeitern. Bitte betrachten Sie diesen Überblick unserer Arbeit als eine Einladung, Berlin-Buch zu besuchen und einen näheren Eindruck zu gewinnen. Walter Birchmeier Wissenschaftlicher Stiftungsvorstand XII Foreword
Cardiovascular and Metabolic Diseases Herz-Kreislauf- und Stoffwechselerkrankungen Coordinator: Thomas Willnow Hypertension, Vascular Disease, and Kidney Disease Coordinator: Thomas Willnow Heart Disease Coordinator: Ludwig Thierfelder Genetics, Genomics, Bioinformatics, and Metabolism Coordinator: Nikolaus Rajewsky
Page 1 and 2: Research Report 2008 MDC Berlin-Buc
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Page 5 and 6: Cell Polarity and Epithelial Morpho
Page 7 and 8: Molecular Cell Biology and Gene The
Page 9 and 10: Foreword Vorwort As this book was b
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Page 13: Two major grants from the Helmholtz
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Genetics, Genomics, Bioinformatics,
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Physiology and Pathology of Ion Tra
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Technical Assistants Alexander Fast
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Structure of the Group Group Leader
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Cancer Research Krebsforschung Coor
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how they infiltrate surrounding tis
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(Photo: David Ausserhofer/Copyright
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degradation (ERAD) pathway. In the
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Structural and Functional Genomics
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ated with the deregulation of cell
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A B C Only functional Met keratinoc
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I) Conditional ablation of the Bmp
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Genetics of Tumor Progression and M
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Signaling Mechanisms in Embryonic S
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Surgical Oncology Peter M. Schlag O
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Structure bition of differentiation
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such as self-renewal and differenti
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Signal Transduction in Tumor Cells
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Control of DNA Replication Manfred
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Nuclear Signalling and Chromosomal
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a. b. Figure 1. The Sleeping Beauty
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Structural and Functional Genomics
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A B Figure 2. Palmitoylation of the
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RNA Chemistry Eckart Matthes Hydrox
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Structure and Membrane Interaction
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Tumor Immunology Coordinator: Marti
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Formation of segregated ectopic fol
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Regulatory Mechanisms of Lymphocyte
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Biology and Targeted Therapy of Lym
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A Figure 1. Function of BH3-only pr
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Molecular Immunotherapy Antonio Pez
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Molecular Immunology and Gene Thera
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Molecular Cell Biology and Gene The
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A B C D CD39+ Treg cells and multip
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Experimental Pharmacology Iduna Fic
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Function and Dysfunction of the Ner
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(Photo: Dr. Hagen Wende, Research G
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tion of proteins causes human neuro
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- Pathophysiological Mechanisms of
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Stucture of the Group Group Leader
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What are the physiological features
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Visualization of the UniHi interact
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Dagmar Ehrnhöfer* Manuela Jacob* M
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Lack of axonal bifurcation within t
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Molecular Physiology of Somatic Sen
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Mitochondrial Dynamics Christiane A
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Neuronal Stem Cells Gerd Kempermann
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Targeting Ion Channel Function Ines
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RNA Editing and Hyperexcitability D
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Molecular Neurology Frauke Zipp T h
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Academics Akademische Aktivitäten
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Charité-Universitätsmedizin Berli
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Helmholtz Fellows Helmholtz-Stipend
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(Photo: Cécile Otten, Research Gro
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2007 19. January Neujahrsempfang de
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Speaker Institute Titel of Seminar
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Overview Überblick
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erzielen, brauchen wir neue gemeins
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The Clinical Research Center (CRC)
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y such scientists in conjunction wi
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Zudem bietet das ECRC-Modell eine h
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(Photo: David Ausserhofer/ Copyrigh
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Business School” addressed challe
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Prof. Dr. Gary R. Lewin MDC Berlin-
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Dr. Thomas Müller Prof. Dr. Claus
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Type of Financing/Art der Finanzier
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Collaborative Research Centres (SFB
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Figures for technology transfer/Ken
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MDC MAX-DELBRÜCK-CENTRUM FÜR MOLE
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Buschow, Christian . . . . . . . .
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Herrmann, Ina . . . . . . . . . . .
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Mensen, Angela . . . . . . . . . .
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Schwarzer, Rolf . . . . . . . . . .
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Campus Map Campusplan Robert-Rössl
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How to find your way to the MDC Der
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