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Seminars Seminare 2006 Speaker Institute Titel of Seminar Kerstin Amann Friedrich-Alexander-Universität Erlangen-Nürnberg Atherosclerosis and vascular calcification in renal failure Miguel Andrade Ottawa, Health Research Institute Computational approaches to the study of gene and protein function Hellmut Augustin Klinik für Tumorbiologie, Freiburg Regulation of vascular homeostasis by angiogenic cytokines Christopher Baum MHH Hannover Präsident der Deutschen Gentherapie in Deutschland? Gesellschaft für Gentherapie (DGGT) Axel Behrens Cancer Research UK, London Research Institute Transcriptional regulation by JNK signalling in neurodegeneration and cancer Brian J. Billups University of Leicester Modulation of neurotransmitter release from the calyx of Held presynaptic terminal J. Julian Blow Cancer Research UK University of Dunde How to ensure precise genome duplication – replication licensing and dormant origins Christoph Borner Institute of Molecular Medicine and Cell Research, The Bcl-2 family on mitochondria: Who is talking Univ. Freiburg with whom? Rod Bremner University of Toronto, Department of The RB and E2F families in neurogenesis and cancer Ophthalmology and Visual Science Paul Brindle Department of Biochemistry St. Jude Children’s Analysis of the global transcriptional coactivators Research Hospital Lauderdale, Memphis, TN CBP and p300 in vivo Peter Brophy University of Edinburgh How do vertebrate nerves switch to saltatory conduction? Patrik Brundin Lund University Huntington’s disease: motor, cognitive or endocrine disorder? Geoffrey Burnstock Royal Free & Univ. College London Purinergic Signalling: Therapeutic Potential Arthur M. Butt University of Portsmouth Novel NG2-glia: What’s in a name? Andrew C. B. Cato Institute of Toxicology and Genetics Attenuation of IgE receptor signalling in mast cells: Forschungszentrum Karlsruhe a molecular model for the anti-inflammatory action of glucocorticoids Ajay Chitnis NIH Bethesda, USA Mind bomb, Mosaic Eyes and Notch signaling in Neurogenesis and Rhombomere boundary formation M. Francesca Cordeiro UCL Institute of Ophthalmology London Seeing is believing Jacqueline Deschamps Hubrecht Laboratory Utrecht Hox, Cdx and the genetic networks driving axial extension and patterning in the mouse Peter ten Dijke Leiden University Medical Center Perturbation of TGF-β signaling in human diseases Jürgen Dittmer University of Halle-Wittenberg The Biology of the Ets1 Proto-Oncogene Zelig Eshhar Weizmann Institute, Israel Adoptive cancer immunotherapy using genetically modified T cells Laurent Fasano LGPD, Marseilles From fly to mice: characterization of the Teashirt (Tshz) gene family Dirk Feldmeyer Research Center Juelich Neuronal microcircuits in the somatosensory barrel cortex Andreas Frick MPI Heidelberg Synaptic dynamics in cortical microcircuits Makoto Furutani-Seiki Kyoto University, Japan Medaka and zebrafish complement to uncover functions of vertebrate genome 196 Academics
Speaker Institute Titel of Seminar Vittorio Gallo Washington School of Medicine Novel regulators of oligodendrocyte progenitor migration and differentiation Stefan Gaubatz Biocenter/ University of Würzburg Dual role of the human synMuv-like LIN-9 protein in the retinoblastoma pathway and in activation of G2/M genes by B-MYB Michael Gekle Physiologisches Institut Universitäts- Kardiovaskuläre Aldosteronwirkungen: „Missbrauch“ klinikum Würzburg des EGF-Rezeptors? Gérard Gradwohl INSERM, France Transcriptional regulation of pancreatic endocrine cell differentiation Frank Gieseler University Hospital of Kiel Molecular interaction between the coagulation system and tumour cells Oliver Griesbeck MPI Martinsried Designing and Exploiting Green Fluorescent Protein Biosensors Dirk Heinz GBF, Braunschweig Structural basis of microbial pathogenesis Johan Hoebeke Institut de Biologie Moléculaire et Antibodies as markers of G protein coupled receptors Cellulaire Strasbourg (GPCR) dimerisation Alexander Hoffmann Dept. of Chemistry and Biochemistry University The NF-κB signaling module as an integrator of of California, San Diego inflammatory and developmental signals Jane Holland University of Adelaide, Australia CXCL12 and CCL19 chemokines influence the metastatic pathway in breast cancer cells Mathias Jucker Hertie-Institute for Clinical Brain Cerebral Amyloidosis: Mechanism, Models, Therapy Research Tuebingen Axel Kallies The Walter and Eliza Hall Institute of Blimp-1 is essential for terminal lymphocyte Medical Research Australia differentiation and function Benjamin Kaupp Research Center Juelich GARPs – unstructured proteins in photoreceptors Thomas Keßler Heinrich-Heine Universität Düsseldorf A novel cellular function of the Drosophila Caspase inhibitor DIAP1 Norbert Kienzle Queensland Institute of Medical Deviation of tumor immunity by IL-4 Research Brisbane, Australia Christian Klämbt Institute for Neurobiology Münster Molecular control of glial cell differentiation in Drosophila Arthur Konnerth University of Munich Cortical calcium signaling: from spiny dendrites to neural circuits Yury Kovalchuk Technical University Munich Neuronal dendritic calcium signalling and synaptic plasticity Jörg Labahn Research Center Juelich Signal transduction in the sensoryrhodopsin-trans ducer system Karl-Josef Langen Research Center Juelich Brain tumor diagnostics with F-18-labelled amino acids and PET Thomas Langenickel NIH Bethesda Deletion of hKIS accelerates intimal hyperplasia in response to vascular injury and enhances migratory activity of VSMC Thomas Langer Universität Köln Protein activation or degradation:the Janus face of AAA proteases in mitochondria David Largaespada Department of Genetics, Cell Biology and Transposon-based, forward genetic screens for Development, University of Minnesota medically relevant traits in mice Academics 197
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Research Report 2008 MDC Berlin-Buc
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Research Report 2008 (covers the pe
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Cell Polarity and Epithelial Morpho
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Molecular Cell Biology and Gene The
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Foreword Vorwort As this book was b
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which survey the quality of protein
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Two major grants from the Helmholtz
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Cardiovascular and Metabolic Diseas
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ing on this topic have made importa
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explain why a certain gene or seque
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Figure 2. Uptake of lipoprotein (A)
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Molecular Mechanisms in Embryonic F
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Cardiovascular Hormones Michael Bad
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Angiogenesis and Cardiovascular Pat
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Hypertension, Vascular Disease, Gen
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Structure of the Group Group Leader
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eceptors did not change. Thus, syst
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Mechanisms of Hypertensioninduced T
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Differentiation and Regeneration of
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Heart Diseases Coordinator: Ludwig
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Figure 1. 3D-model of the actomyosi
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Cell Polarity and Epithelial Morpho
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Molecular and Cell Biology of the (
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number of circulating antibodies to
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Genetics, Genomics, Bioinformatics,
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Physiology and Pathology of Ion Tra
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Technical Assistants Alexander Fast
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Cancer Research Krebsforschung Coor
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how they infiltrate surrounding tis
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(Photo: David Ausserhofer/Copyright
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degradation (ERAD) pathway. In the
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Structural and Functional Genomics
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ated with the deregulation of cell
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A B C Only functional Met keratinoc
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I) Conditional ablation of the Bmp
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Genetics of Tumor Progression and M
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Signaling Mechanisms in Embryonic S
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Surgical Oncology Peter M. Schlag O
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Structure bition of differentiation
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such as self-renewal and differenti
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Signal Transduction in Tumor Cells
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Control of DNA Replication Manfred
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Nuclear Signalling and Chromosomal
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a. b. Figure 1. The Sleeping Beauty
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Structural and Functional Genomics
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A B Figure 2. Palmitoylation of the
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RNA Chemistry Eckart Matthes Hydrox
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Structure and Membrane Interaction
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Tumor Immunology Coordinator: Marti
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Formation of segregated ectopic fol
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Regulatory Mechanisms of Lymphocyte
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Biology and Targeted Therapy of Lym
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A Figure 1. Function of BH3-only pr
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Molecular Immunotherapy Antonio Pez
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Molecular Immunology and Gene Thera
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Molecular Cell Biology and Gene The
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A B C D CD39+ Treg cells and multip
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Experimental Pharmacology Iduna Fic
Page 159 and 160: Structure of the Group Group Leader
Page 161 and 162: Function and Dysfunction of the Ner
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Page 165 and 166: tion of proteins causes human neuro
Page 167 and 168: - Pathophysiological Mechanisms of
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Page 175 and 176: What are the physiological features
Page 179 and 180: Visualization of the UniHi interact
Page 181 and 182: Dagmar Ehrnhöfer* Manuela Jacob* M
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Page 187 and 188: Molecular Physiology of Somatic Sen
Page 189 and 190: Mitochondrial Dynamics Christiane A
Page 191 and 192: Neuronal Stem Cells Gerd Kempermann
Page 193 and 194: Targeting Ion Channel Function Ines
Page 195 and 196: RNA Editing and Hyperexcitability D
Page 197 and 198: Molecular Neurology Frauke Zipp T h
Page 201 and 202: Academics Akademische Aktivitäten
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Page 209: 2007 19. January Neujahrsempfang de
Page 213 and 214: Speaker Institute Titel of Seminar
Page 215 and 216: Speaker Institute Titel of Seminar
Page 217 and 218: Overview Überblick
Page 219 and 220: erzielen, brauchen wir neue gemeins
Page 221 and 222: The Clinical Research Center (CRC)
Page 223 and 224: y such scientists in conjunction wi
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Page 229 and 230: Business School” addressed challe
Page 231 and 232: Prof. Dr. Gary R. Lewin MDC Berlin-
Page 233 and 234: Dr. Thomas Müller Prof. Dr. Claus
Page 235 and 236: Type of Financing/Art der Finanzier
Page 237 and 238: Collaborative Research Centres (SFB
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Page 241 and 242: MDC MAX-DELBRÜCK-CENTRUM FÜR MOLE
Page 243 and 244: Buschow, Christian . . . . . . . .
Page 245 and 246: Herrmann, Ina . . . . . . . . . . .
Page 247 and 248: Mensen, Angela . . . . . . . . . .
Page 249 and 250: Schwarzer, Rolf . . . . . . . . . .
Page 251 and 252: Campus Map Campusplan Robert-Rössl
Page 253 and 254: How to find your way to the MDC Der
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