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Content Inhalt Foreword Vorwort . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . VII-XII Cardiovascular and Metabolic Disease Research Herz-Kreislauf- und Stoffwechselerkrankungen . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1-5 Hypertension, Vascular, and Kidney Diseases Coordinator: Thomas E. Willnow Molecular Cardiovascular Research Thomas E. Willnow . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6-8 Molecular Mechanisms in Embryonic Forebrain Development Annette Hammes (Helmholtz Fellow) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9-10 Cardiovascular Hormones Michael Bader . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11-12 Angiogenesis and Cardiovascular Pathology Ferdinand le Noble. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13-14 Hypertension, Vascular Disease, Genetics, and Nephrology Friedrich C. Luft . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15-17 Cytochrome P450-dependent Eicosanoids in the Regulation of Cellular and Organ Function Wolf-Hagen Schunck . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 18-19 Cardiovascular and Metabolic Regulation Jens Jordan . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 20-22 Mechanisms of Hypertension-induced Target-organ Damage Dominik N. Müller (Helmholtz Fellow). . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 23-24 Differentiation and Regeneration of Kidney Epithelia Kai Schmidt-Ott (Emmy Noether Research Group) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25-26 Heart Diseases Coordinator: Ludwig Thierfelder Cardiovascular Molecular Genetics Ludwig Thierfelder . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 27-29 Genetic Disorders of the Cardiovascular System Brenda Gerull (Helmholtz Fellow) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 30-31 Clinical Cardiology Rainer Dietz . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 32-33 Cardiovascular Magnetic Resonance Jeanette Schulz-Menger . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 34-35 Transcription Factors in Myocardial Stress Remodeling Martin W. Bergmann (Helmholtz Fellow). . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 36-37 Molecular Muscle Physiology Ingo L. Morano . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 38-40 II Content
Cell Polarity and Epithelial Morphogenesis Salim Abdelilah-Seyfried . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 41-42 Molecular and Cell Biology of the (Epi)genome M. Cristina Cardoso . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 43-45 Neuromuscular and Cardiovascular Cell Biology Michael Gotthardt . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 46-47 Immunology of Cardiovascular Diseases Gerd Wallukat . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 48-50 Genetics, Genomics, Bioinformatics, and Metabolism Coordinator: Nikolaus Rajewsky Systems Biology of Gene Regulatory Elements Nikolaus Rajewsky . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 51-52 Physiology and Pathology of Ion Transport Thomas Jentsch . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 53-55 Genomic Dissection of Complex Cardiovascular Diseases Norbert Hübner . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 56-57 Mobile DNA Zsuzsanna Izsvák . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 58-59 Genetics of Allergic Disease Young-Ae Lee . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 60-61 Intracellular Signaling and Mass Spectrometry Matthias Selbach (Helmholtz Fellow) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 62-63 Cancer Research Krebsforschungsprogramm Coordinator: Walter Birchmeier . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 65-75 Signalling Pathways, Cell Biology, and Cancer Coordinator: Achim Leutz Signals provided by Wnt/β-catenin and the Met Tyrosine Kinase in Development, Cancer, and Cardiovascular Disease Walter Birchmeier . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 76-80 Genetics of Tumor Progression and Metastasis Ulrike S. Ziebold. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 81-82 Signaling Mechanisms in Embryonic Stem Cells Daniel Besser (Helmholtz Fellow) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 83-84 Surgical Oncology Peter M. Schlag . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 85-87 Cell Differentiation and Tumorigenesis Achim Leutz . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 88-91 Content III
Page 1 and 2: Research Report 2008 MDC Berlin-Buc
Page 3: Research Report 2008 (covers the pe
Page 7 and 8: Molecular Cell Biology and Gene The
Page 9 and 10: Foreword Vorwort As this book was b
Page 11 and 12: which survey the quality of protein
Page 13 and 14: Two major grants from the Helmholtz
Page 15 and 16: Cardiovascular and Metabolic Diseas
Page 17 and 18: ing on this topic have made importa
Page 19 and 20: explain why a certain gene or seque
Page 21 and 22: Figure 2. Uptake of lipoprotein (A)
Page 23 and 24: Molecular Mechanisms in Embryonic F
Page 25 and 26: Cardiovascular Hormones Michael Bad
Page 27 and 28: Angiogenesis and Cardiovascular Pat
Page 29 and 30: Hypertension, Vascular Disease, Gen
Page 31 and 32: Structure of the Group Group Leader
Page 35 and 36: eceptors did not change. Thus, syst
Page 37 and 38: Mechanisms of Hypertensioninduced T
Page 39 and 40: Differentiation and Regeneration of
Page 41 and 42: Heart Diseases Coordinator: Ludwig
Page 53 and 54: Figure 1. 3D-model of the actomyosi
Page 55 and 56:
Cell Polarity and Epithelial Morpho
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Molecular and Cell Biology of the (
Page 59 and 60:
Structure of the Group Group Leader
Page 61 and 62:
Page 63 and 64:
number of circulating antibodies to
Page 65 and 66:
Genetics, Genomics, Bioinformatics,
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Physiology and Pathology of Ion Tra
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Technical Assistants Alexander Fast
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Cancer Research Krebsforschung Coor
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how they infiltrate surrounding tis
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(Photo: David Ausserhofer/Copyright
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degradation (ERAD) pathway. In the
Page 87 and 88:
Structural and Functional Genomics
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ated with the deregulation of cell
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A B C Only functional Met keratinoc
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I) Conditional ablation of the Bmp
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Genetics of Tumor Progression and M
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Signaling Mechanisms in Embryonic S
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Surgical Oncology Peter M. Schlag O
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Structure bition of differentiation
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such as self-renewal and differenti
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Signal Transduction in Tumor Cells
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Page 113 and 114:
Page 115 and 116:
Control of DNA Replication Manfred
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Nuclear Signalling and Chromosomal
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a. b. Figure 1. The Sleeping Beauty
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Structural and Functional Genomics
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A B Figure 2. Palmitoylation of the
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RNA Chemistry Eckart Matthes Hydrox
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Structure and Membrane Interaction
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Tumor Immunology Coordinator: Marti
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Formation of segregated ectopic fol
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Regulatory Mechanisms of Lymphocyte
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Biology and Targeted Therapy of Lym
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A Figure 1. Function of BH3-only pr
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Molecular Immunotherapy Antonio Pez
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Molecular Immunology and Gene Thera
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Molecular Cell Biology and Gene The
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A B C D CD39+ Treg cells and multip
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Experimental Pharmacology Iduna Fic
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Function and Dysfunction of the Ner
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(Photo: Dr. Hagen Wende, Research G
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tion of proteins causes human neuro
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- Pathophysiological Mechanisms of
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Stucture of the Group Group Leader
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What are the physiological features
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Visualization of the UniHi interact
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Dagmar Ehrnhöfer* Manuela Jacob* M
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Page 185 and 186:
Lack of axonal bifurcation within t
Page 187 and 188:
Molecular Physiology of Somatic Sen
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Mitochondrial Dynamics Christiane A
Page 191 and 192:
Neuronal Stem Cells Gerd Kempermann
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Targeting Ion Channel Function Ines
Page 195 and 196:
RNA Editing and Hyperexcitability D
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Molecular Neurology Frauke Zipp T h
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Academics Akademische Aktivitäten
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Charité-Universitätsmedizin Berli
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Helmholtz Fellows Helmholtz-Stipend
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(Photo: Cécile Otten, Research Gro
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2007 19. January Neujahrsempfang de
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Speaker Institute Titel of Seminar
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Overview Überblick
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erzielen, brauchen wir neue gemeins
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The Clinical Research Center (CRC)
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y such scientists in conjunction wi
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Zudem bietet das ECRC-Modell eine h
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(Photo: David Ausserhofer/ Copyrigh
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Business School” addressed challe
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Prof. Dr. Gary R. Lewin MDC Berlin-
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Dr. Thomas Müller Prof. Dr. Claus
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Type of Financing/Art der Finanzier
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Collaborative Research Centres (SFB
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Figures for technology transfer/Ken
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MDC MAX-DELBRÜCK-CENTRUM FÜR MOLE
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Buschow, Christian . . . . . . . .
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Herrmann, Ina . . . . . . . . . . .
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Mensen, Angela . . . . . . . . . .
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Schwarzer, Rolf . . . . . . . . . .
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Campus Map Campusplan Robert-Rössl
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