Eble JN, Sauter G., Epstein JI, Sesterhenn IA - iarc

A
Fig. 3.27 A, B Foamy gland adenocarcinoma.
B
A
B
Fig. 3.28 A Colloid adenocarcinoma. B Acinar adenocarcinoma of the prostate, colloid variant left part.
Mucinous prostate adenocarcinomas
behave aggressively {710,2207,2274}. In
the largest reported series, 7 of 12
patients died of tumour (mean 5 years)
and 5 were alive with disease (mean 3
years). Although these tumours are not
as hormonally responsive as their nonmucinous
counterparts, some respond to
androgen withdrawal. Mucinous prostate
adenocarcinomas have a propensity to
develop bone metastases and increased
serum PSA levels with advanced disease.
Oncocytic variant
Prostatic adenocarcinoma rarely is composed
of large cells with granular
eosinophilic cytoplasm. Tumour cells
have round to ovoid hyperchromatic
nuclei, and are strongly positive for PSA.
Numerous mitochondria are seen on ultrastructural
examination. A high Gleason
grade {1972,2080}, elevated serum PSA
{2080} and metastasis of similar morphology
{1972} have been reported.
Lymphoepithelioma-like variant
This undifferentiated carcinoma is characterized
by a syncytial pattern of malignant
cells associated with a heavy lymphocytic
infiltrate. Malignant cells are
Fig. 3.29 Adenocarcinoma of the prostate with
signet-ring cell-like features.
A
Fig. 3.30 A Mucinous adenocarcinoma. B Colloid carcinoma.
B
Acinar adenocarcinoma 177