Eble JN, Sauter G., Epstein JI, Sesterhenn IA - iarc

esults in intratumoral aneurysms. Onefourth
of MSTs feature juxtaglomerular
cell hyperplasia within entrapped
glomeruli, which may occasionally lead
to hypertension associated with hyperreninism.
One-fifth of MSTs demonstrate
heterologous differentiation in the form of
glia or cartilage. Necrosis is unusual, and
vascular invasion is absent in MST.
Immunoprofile
MSTs are typically immunoreactive for
CD34, but labeling may be patchy.
Desmin, cytokeratins, and S-100 protein
are negative, though heterologous glial
areas label for GFAP and S-100 protein.
Prognosis and predictive factors
All identified MSTs have had a benign
course, with no reports of metastases or
even local recurrence as of this writing.
Excision is adequate therapy. Rare
patients have suffered morbidity or mortality
from the manifestations of extra
renal angiodysplasia, apparently
induced by MST.
A
B
Fig. 1.64 Metanephric stromal tumour. A Note spindled and epithelioid stromal cells and (B) striking angioplasia.
A
B
Fig. 1.65 Metanephric stromal tumour. A Angiodysplasia and concentric perivascular growth. B CD34 positivity of spindle cells, predominantly away from entrapped
tubules.
A
B
Fig. 1.66 Metanephric stromal tumour. A Glial-epithelial complexes. B Note positivity for GFAP in glial foci.
Metanephric stromal tumour
47