Eble JN, Sauter G., Epstein JI, Sesterhenn IA - iarc

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Subject index t(X:17) renal carcinoma, 37 34bE12, cytokeratin, 24, 27, 34, 40, 172, 173, 174, 201, 206 3p deletions, 24, 25 A Acetylator genotypes, 13 Acinar adenocarcinoma, 162, 175, 177, 199, 200, 201 Acrochordon, 20 Adenomatoid tumour, 218, 267, 268, 269 Adenomyoma, 214 Adenosquamous carcinoma, 160, 205, 281, 284, 287, 288 Adrenogenital syndrome, 251, 252 Adult mesoblastic nephroma, 77 Adult type granulosa cell tumour, 218, 257 AE1/AE3, cytokeratin, 24, 27, 36, 80, 101, 102, 138, 152, 233, 268, 269, 271, 272 AFP, See Alpha fetoprotein Aggressive angiomyxoma, 276 AKT, 61 Albumin, 241 Alpha fetoprotein, 220, 221, 224, 232, 235, 236, 238, 240-242, 244, 247- 249, 255, 272 Alpha-2-globulin, 13 Alpha-methyl-CoA racemase, 174 AML, 65-69 Amyloidosis, 13 Analgesics, 13, 94, 151 Androblastoma, 253 Androgen insensitivity syndrome, 251, 254 Androgen receptor, 164, 172, 174, 186 Angiodysplasia, 45-47 Angiogenesis, 15, 17, 109 Angiokeratoma, 293-295 Angiolymphoid hyperplasia with eosinophilia, 295 Angioma, 51 Angiomyofibroblastoma, 274-276 Angiomyolipoma, 10, 14, 52, 63, 65-68, 70 Angiosarcoma, 10, 64, 71, 90, 102, 141, 146, 153, 160, 178, 210, 211, 215, 293, 294, 296, 297 Angiotensin 1-converting enzyme, 233 Aniridia, 48, 51 Anthracyclines, 105 Antihypertensive drugs, 13 Antoni A pattern, 75 Antoni B pattern, 75, 295 APC, 225 Arsenic, 12, 94 Asbestos, 12, 269 ASPL, 37, 38 ASPL-TFE3 carcinomas, 37 ASPSCR1, 37 Atrophic variant, 175 Atypical adenomatous hyperplasia, 171, 173, 174 Atypical lentiginous hyperplasia, 292 Atypical melanocytic nevi of the acral/genital type, 292 Atypical neurofibromas, 145 Azzopardi phenomenon, 82, 135 B Balkan nephropathy, 151 Basal cell adenoma, 160 Basal cell carcinoma, 160, 206, 281, 288 Basal cell hyperplasia, 172, 206 Basaloid carcinoma, 281, 284, 286 B-cell acute lymphoblastic leukaemia, 60 B-cell lymphoma, 85, 147, 264 BCL10, 225 BCL2, 57, 79, 192, 197, 206, 265 Beckwith-Wiedemann syndrome, 51, 52 Bellini duct carcinoma, 33 Benign mesothelioma, 218, 268, 270 bFGF, 25 BHD, 15, 18, 20, 21 BHD syndrome, 20 Bilateral papillary renal cell tumours, 17 Birth weight, 13, 223 Birt-Hogg-Dubé syndrome, 20, 21 Bizarre leiomyoma, 211 Blastemal cells, 48-52, 54 Bloom syndrome, 51 Body mass index (BMI), 12 Bone metastases, 13, 57, 96, 166, 177, 205 Bone metastasizing renal tumour of childhood, 56 Bowen disease, 281, 289-291 Bowenoid papulosis, 289, 290 Brenner tumour, 218, 263 Broad ligament cystadenoma, 15, 16 Brunn nests, 99, 114, 120 Burkitt lymphoma, 147 Burned out germ cell tumour, 248 Buschke-Löwenstein tumour, 289 C CA125, 100, 133, 213, 214 Cadmium, 12 Calcifications, 254, 260, 262 Calcifying fibrous (pseudo) tumour, 274, 276 Call-Exner bodies, 257, 258 Calponin, 66, 295 CAM 5.2, 24, 27, 36, 40, 80, 233, 272 Carcinoembryonic antigen. 27, 36, 100, 133, 214, 235, 238, 245, 247, 256, 268, 270, 271, 288, 291 Carcinoid, 10, 81, 84, 90, 99, 135, 138, 153, 160, 207, 218, 245, 246, 262, 279 Carcinoma associated with neuroblastoma, 10, 39 Carcinoma of Skene, Cowper and Littre glands, 90 Carcinoma of the collecting ducts of Bellini, 10, 33, 34 Carcinosarcoma, 63, 102, 160, 178 Carney syndrome, 253, 255 Caruncle, 147, 157 CCNA, 226 Subject index 353
CCNB, 226 CCND1, 105, 108 CCND2, 226, 227 CCNE, 226 CCRCC, 15, 16 CCSK, 56, 57 CD10, 24, 31, 34, 37, 40, 265 CD117, 84, 230, 232-235 CD143, 233 CD15, 34, 40 CD30, 232-235, 238, 249, 298 CD31, 62, 64, 141, 296 CD34, 45, 47, 57, 60, 62, 64, 73, 75, 109, 141, 209, 268, 276, 295, 296 CD44, 117, 192 CD56, 82, 85, 264 CD57, 45 CD63, 66 CD68, 66, 143 CD99, 57, 62, 75, 79, 80, 84, 258 CDC, 34 CDK4, 105, 108 CDKN1A, 225 CDKN1B, 225 CDKN2A, 107, 121, 225 CDKN2B, 107, 121, 225 CDKN2C, 225 CDKN2D, 225 CEA, See Carcinoembryonic antigen Cellular angiofibroma, 275, 276 Cellular congenital mesoblastic nephroma, 60 Cellular neurofibromas, 145 Cerebral gigantism, 51 Charcot-Böttcher crystals, 255 Chondroma, 160, 209 Chondrosarcoma, 102, 103, 144, 160, 178, 209, 211, 236, 247 Choriocarcinoma, 10, 153, 160, 215, 218, 221, 224, 233, 238, 241-244, 247-249 Chromogranin A, 82, 84, 85, 135-138, 192, 196, 207, 247, 262 Chromophobe renal cell carcinoma, 10, 30-32 Chronic cystitis, 94, 147 Chronic prostatitis, 184 CK14, 24 CK18, 24, 40 CK19, 24, 34, 40 CK20, 101, 133, 204 CK7, 40, 133, 204 CK8, 24, 101, 233 C-KIT, 226, 232, 233 Clear cell adenocarcinoma, 133, 213 Clear cell carcinoma, 25, 281, 285, 287 Clear cell renal carcinoma, 10, 15, 16, 21, 23-25, 34, 66, 133 Clear cell sarcoma, 10, 52, 56, 57, 293, 296, 297 Clear cell sarcoma of the kidney, 56 Clear cell variant of urothelial carcinoma, 103 Cloacogenic carcinoma, 172 Clusterin, 123 C-MYC, 197 Coagulopathy, 13 Collecting duct carcinoma, 33, 34, 36 Collective duct carcinoma, 18 Colloid and signet ring variant, prostate adenocarcinoma, 176 Comedonecrosis, 181 Condyloma acuminatum, 127, 157 Congenital mesoblastic nephroma, 10, 60, 61 Cowper glands, 90, 155, 172 COX-2, 109 Cribriform pattern, 180, 199, 201 Cryptorchidism, 223, 229, 235, 251 Cul-2, 17 Cutaneous leiomyomas, 18, 19 Cutaneous nevi, 51 Cyclin-dependent kinase inhibitor, 17 Cyclooxygenase, 109 Cyclophosphamide, 94, 102, 140 Cystadenocarcinoma, 262 Cystadenoma, 160, 213, 214, 218, 262, 266, 271, 272 Cystic hamartoma of renal pelvis, 77 Cystic mesothelioma, 218 Cystic nephroma, 10, 55, 76 Cystic nodular hyperplasia of the prostate, 213 Cystic partially differentiated nephroblastoma, 10, 48, 55 Cystic trophoblastic tumour, 243 Cystitis cystica, 99, 120, 132, 147 Cystitis glandularis, 99, 130, 132, 147 Cytokeratin 20, 111-113, 117, 118, 120, 123, 134, 214 Cytokeratin 7, 18, 45, 104, 114, 134, 214 D DBCCR1, 121 DCC, 225 Dedifferentiated liposarcomas, 275 Denuding cystitis, 119 Denys-Drash syndrome, 51 Dermatofibrosarcoma protuberans, 293, 296, 297 Dermoid cyst, 218, 244, 245, 247 Desmoplastic small round cell tumour, 218, 272, 274 Desmoplastic stromal response, 97, 175, 202 Diethylstilboestrol, 12, 223 Ductal adenocarcinoma, 199, 200, 201 E EBV, See <strong>Epstein</strong>-Barr virus E-cadherin, 25, 123, 187, 192 EGFR, See Epidermal growth factor receptor Elongin, 17 Embryonal carcinoma, 160, 218, 221, 224, 227, 233, 234, 236-240, 244, 247-250 Embryonal rhabdomyosarcoma, 139, 211, 277 Endodermal sinus tumour, 238, 240, 241 Endolymphatic sac tumours, 15, 16 Endometriosis, 130, 133, 134, 146 Ependymoblastoma, 247 Epidermal growth factor receptor, 25, 105, 107, 108, 109, 122, 126 Epidermoid cyst, 244, 245, 247 Epididymal cystadenomas, 16 Epigenetic silencing, 24 Epithelial membrane antigen, 24, 26, 34, 40, 45, 57, 80, 104, 134, 238, 243, 256, 271 Epithelioid angiomyolipoma, 10, 68 Epithelioid angiosarcoma, 141 Epithelioid haemangioendothelioma, 293, 294, 297 Epithelioid sarcoma, 293-297 Epithelioid/pleomorphic angiomyolipoma, 64 EPO, See Erythropoietin <strong>Epstein</strong>-Barr virus, 85, 101, 147, 178, 264, 265 Erythrocytosis, 13, 17 Erythroplasia of Queyrat, 281, 289 Erythropoietin, 13, 17, 48 Estrogen, 13, 66, 77, 78, 133, 154, 210, 223, 251, 276 354 Subject index
Page 1 and 2:
World Health Organization Classific
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This volume was produced in collabo
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Contents 1 Tumours of the kidney 9
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CHAPTER 1 Tumours of the Kidney Can
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TNM classification of renal cell ca
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one quarter of kidney cancers in bo
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Familial renal cell carcinoma M.J.
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Table 1.02 Genotype - phenotype cor
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A B Fig. 1.11 A Multiple cutaneous
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A B Fig. 1.14 Birt-Hogg-Dubé syndr
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Clear cell renal cell carcinoma D.J
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Fig. 1.20 Clear cell renal cell car
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Papillary renal cell carcinoma B. D
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A B Fig. 1.29 Papillary renal cell
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Fig. 1.33 Chromophobe RCC with sarc
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Carcinoma of the collecting ducts o
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Renal medullary carcinoma C.J. Davi
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Renal carcinomas associated with Xp
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Renal cell carcinoma associated wit
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Papillary adenoma of the kidney J.N
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of this tumour. Microscopic extensi
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A B Fig. 1.59 Metanephric adenoma.
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esults in intratumoral aneurysms. O
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peritumoural fibrous pseudocapsule.
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increases in prevalence to approxim
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Nephrogenic rests and nephroblastom
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Cystic partially differentiated nep
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A B Fig. 1.80 Clear cell sarcoma of
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A B Fig. 1.85 Rhabdoid tumour of th
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transcription factor is fused to th
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Leiomyosarcoma S.M. Bonsib Definiti
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Angiomyolipoma G. Martignoni M.B. A
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melanocytic and smooth muscle marke
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Multinucleated and enlarged ganglio
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Haemangioma P. Tamboli Definition H
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Fig. 1.107 Juxtaglomerular cell tum
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Intrarenal schwannoma I. Alvarado-C
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Mixed epithelial and stromal tumour
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Synovial sarcoma of the kidney J.Y.
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Renal carcinoid tumour L.R. Bégin
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Primitive neuroectodermal tumour (E
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Paraganglioma / Phaeochromocytoma P
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Leukaemia A. Orazi Interstitial inf
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WHO histological classification of
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TNM classification of carcinomas of
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The risk of bladder cancer goes dow
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Tumour spread and staging Urinary b
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feature in such patients undergoing
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A Fig. 2.12 Infiltrative urothelial
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A Fig. 2.15 A Infiltrating urotheli
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A B Fig. 2.19 A Infiltrative urothe
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Fig. 2.23 Infiltrative urothelial c
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ing systems have been proposed on t
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Non-invasive urothelial tumours G.
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chronically inflamed urothelium and
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Inverted papilloma G. Sauter Defini
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muscle invasive disease, but there
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Fig. 2.42 Non-invasive urothelial n
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A Fig. 2.45 Non-invasive urothelial
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for DBCCR1 silencing {984,2476}. Th
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Squamous cell carcinoma D.J. Grigno
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Fig. 2.51 Squamous cell carcinoma.
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Adenocarcinoma A.G. Ayala P. Tambol
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A B Fig. 2.61 A Adenocarcinoma in s
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A B Fig. 2.65 Intramural urachal ca
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Müllerian origin is postulated for
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A Fig. 2.69 Small cell carcinoma. A
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Carcinoid L. Cheng Definition Carci
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Leiomyosarcoma J. Cheville Definiti
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Osteosarcoma L. Guillou Definition
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Leiomyoma J. Cheville Definition A
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Haemangioma L. Cheng Definition Hae
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Metastatic tumours and secondary ex
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Tumours of the renal pelvis and ure
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nodular, ulcerative or infiltrative
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Tumours of the urethra F. Hofstädt
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usually show enteric, colloid or si
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CHAPTER 3X Tumours of of the the Pr
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TNM classification of carcinomas of
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contrast, mortality among migrants
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Fig. 3.06 Transrectal ultrasound of
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PSA-related diagnostic strategies.
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A B C Fig. 3.10 A,B Section of pros
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pale-clear, similar to benign gland
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A B Fig. 3.20 A, B Adenocarcinoma w
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prostate adenocarcinomas exhibit AR
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A Fig. 3.27 A, B Foamy gland adenoc
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A B Fig. 3.32 A Sarcomatoid carcino
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A B Fig. 3.37 A Gleason score 1+1=2
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A B Fig. 3.43 A Prostate cancer Gle
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Fig. 3.48 Heat map-nature. From S.M
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Fig. 3.51 Prostate cancer. Major su
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many stage T1b cancers. Stage T2 Mo
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Fig. 3.58 Patterns of seminal vesic
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Prostatic intraepithelial neoplasia
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A B Fig. 3.63 A Micropapillary high
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A B Fig. 3.68 A Ductal carcinoma in
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Ductal adenocarcinoma X.J. Yang L.
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Papillary pattern can be seen in bo
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A B Fig. 3.74 A Inflammation withou
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Squamous neoplasms T.H. Van der Kwa
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Neuroendocrine tumours P.A. di Sant
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Mesenchymal tumours J. Cheville F.
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Fig. 3.89 Sarcoma of the prostate.
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Miscellaneous tumours P.H. Tan L. C
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A Fig. 3.96 A Adenocarcinoma of the
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Introduction F.K. Mostofi I.A. Sest
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wartime birth cohorts illustrate th
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Similar tumours as those of group 1
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crucial for the development of this
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A B Fig. 4.09 Spermatocytic seminom
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A B Fig. 4.14 Intratubular germ cel
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A B Fig. 4.19 Seminoma. A Typical s
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Fig. 4.24 Seminoma. Vascular invasi
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Fig. 4.28 Spermatocytic seminoma wi
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A B Fig. 4.33 Embryonal carcinoma.
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A B Fig. 4.38 Yolk sac tumour. A En
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have cytoplasmic lacunae that conta
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A Fig. 4.46 Teratoma. A Longitudina
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A B Fig. 4.51 A Cut surface of derm
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Fig. 4.54 Mixed germ cell tumour. L
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Sex cord / gonadal stromal tumours
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A B C Fig. 4.67 Malignant Leydig ce
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A Fig. 4.73 A Sertoli cell tumour.
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ICD-O codes Granulosa cell tumour 8
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ICD-O code 8592/1 Clinical features
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A B Fig. 4.83 Germ cell-sex cord/go
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A Fig. 4.85 A, B Brenner tumour of
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typical grade III follicular morpho
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testicular parenchyma and tumour te
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A B the surgical scar and adjacent
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Immunoprofile Ordóñez and associa
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often have a grey-white cut surface
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Fig. 4.111 Angiomyofibroblastoma-li
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A B Fig. 4.119 Embryonal rhabdomyos
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Table 4.05 Secondary tumours of the
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A Fig. 5.04 A, B Squamous cell carc
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deformed by an exophytic mass. In s
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A B C Fig. 5.12 A Warty (condylomat
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A Fig. 5.20 Bowenoid papulosis. A,
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three had been circumcized by 9 yea
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Mesenchymal tumours J.F. Fetsch M.
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Fig. 5.31 Neurofibroma of the penis
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oectodermal tumour/Ewing sarcoma [p
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Secondary tumours of the penis C.J.
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Dr John N. EBLE* Dept. of Pathology
Page 297 and 298: Dr Ricardo PANIAGUA Department of C
Page 299 and 300: Source of charts and photographs 1.
Page 301 and 302: References 1. Anon. (1955). Case re
Page 303 and 304: 115. Ariel I, Sughayer M, Fellig Y,
Page 305 and 306: 246. Birt AR, Hogg GR, Dube WJ (197
Page 307 and 308: 374. Cardone G, Malventi M, Roffi M
Page 309 and 310: 502. Corti B, Carella R, Gabusi E,
Page 311 and 312: 633. Donhuijsen K, Schmidt U, Richt
Page 313 and 314: 768. Fischer J, Palmedo G, von Knob
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Page 317 and 318: 1028. Hartmann A, Dietmaier W, Hofs
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Eble JN, Sauter G., Epstein JI, Sesterhenn IA - iarc

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