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World Health Organization Classific
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This volume was produced in collabo
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Contents 1 Tumours of the kidney 9
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CHAPTER 1 Tumours of the Kidney Can
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TNM classification of renal cell ca
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one quarter of kidney cancers in bo
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Familial renal cell carcinoma M.J.
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Table 1.02 Genotype - phenotype cor
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A B Fig. 1.11 A Multiple cutaneous
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A B Fig. 1.14 Birt-Hogg-Dubé syndr
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Clear cell renal cell carcinoma D.J
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Fig. 1.20 Clear cell renal cell car
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Papillary renal cell carcinoma B. D
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A B Fig. 1.29 Papillary renal cell
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Fig. 1.33 Chromophobe RCC with sarc
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Carcinoma of the collecting ducts o
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Renal medullary carcinoma C.J. Davi
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Renal carcinomas associated with Xp
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Renal cell carcinoma associated wit
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Papillary adenoma of the kidney J.N
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of this tumour. Microscopic extensi
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A B Fig. 1.59 Metanephric adenoma.
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esults in intratumoral aneurysms. O
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peritumoural fibrous pseudocapsule.
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increases in prevalence to approxim
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Nephrogenic rests and nephroblastom
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Cystic partially differentiated nep
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A B Fig. 1.80 Clear cell sarcoma of
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A B Fig. 1.85 Rhabdoid tumour of th
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transcription factor is fused to th
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Leiomyosarcoma S.M. Bonsib Definiti
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Angiomyolipoma G. Martignoni M.B. A
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melanocytic and smooth muscle marke
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Multinucleated and enlarged ganglio
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Haemangioma P. Tamboli Definition H
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Fig. 1.107 Juxtaglomerular cell tum
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Intrarenal schwannoma I. Alvarado-C
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Mixed epithelial and stromal tumour
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Synovial sarcoma of the kidney J.Y.
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Renal carcinoid tumour L.R. Bégin
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Primitive neuroectodermal tumour (E
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Paraganglioma / Phaeochromocytoma P
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Leukaemia A. Orazi Interstitial inf
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WHO histological classification of
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TNM classification of carcinomas of
Page 91 and 92:
The risk of bladder cancer goes dow
Page 93 and 94:
Tumour spread and staging Urinary b
Page 95 and 96:
feature in such patients undergoing
Page 97 and 98:
A Fig. 2.12 Infiltrative urothelial
Page 99 and 100:
A Fig. 2.15 A Infiltrating urotheli
Page 101 and 102:
A B Fig. 2.19 A Infiltrative urothe
Page 103 and 104:
Fig. 2.23 Infiltrative urothelial c
Page 105 and 106:
ing systems have been proposed on t
Page 107 and 108:
Non-invasive urothelial tumours G.
Page 109 and 110:
chronically inflamed urothelium and
Page 111 and 112:
Inverted papilloma G. Sauter Defini
Page 113 and 114:
muscle invasive disease, but there
Page 115 and 116:
Fig. 2.42 Non-invasive urothelial n
Page 117 and 118:
A Fig. 2.45 Non-invasive urothelial
Page 119 and 120:
for DBCCR1 silencing {984,2476}. Th
Page 121 and 122:
Squamous cell carcinoma D.J. Grigno
Page 123 and 124:
Fig. 2.51 Squamous cell carcinoma.
Page 125 and 126:
Adenocarcinoma A.G. Ayala P. Tambol
Page 127 and 128:
A B Fig. 2.61 A Adenocarcinoma in s
Page 129 and 130:
A B Fig. 2.65 Intramural urachal ca
Page 131 and 132:
Müllerian origin is postulated for
Page 133 and 134:
A Fig. 2.69 Small cell carcinoma. A
Page 135 and 136:
Carcinoid L. Cheng Definition Carci
Page 137 and 138:
Leiomyosarcoma J. Cheville Definiti
Page 139 and 140:
Osteosarcoma L. Guillou Definition
Page 141 and 142:
Leiomyoma J. Cheville Definition A
Page 143 and 144:
Haemangioma L. Cheng Definition Hae
Page 145 and 146:
Metastatic tumours and secondary ex
Page 147 and 148:
Tumours of the renal pelvis and ure
Page 149 and 150:
nodular, ulcerative or infiltrative
Page 151 and 152:
Tumours of the urethra F. Hofstädt
Page 153 and 154:
usually show enteric, colloid or si
Page 155 and 156:
CHAPTER 3X Tumours of of the the Pr
Page 157 and 158:
TNM classification of carcinomas of
Page 159 and 160:
contrast, mortality among migrants
Page 161 and 162:
Fig. 3.06 Transrectal ultrasound of
Page 163 and 164:
PSA-related diagnostic strategies.
Page 165 and 166:
A B C Fig. 3.10 A,B Section of pros
Page 167 and 168:
pale-clear, similar to benign gland
Page 169 and 170:
A B Fig. 3.20 A, B Adenocarcinoma w
Page 171 and 172:
prostate adenocarcinomas exhibit AR
Page 173 and 174:
A Fig. 3.27 A, B Foamy gland adenoc
Page 175 and 176:
A B Fig. 3.32 A Sarcomatoid carcino
Page 177 and 178:
A B Fig. 3.37 A Gleason score 1+1=2
Page 179 and 180:
A B Fig. 3.43 A Prostate cancer Gle
Page 181 and 182:
Fig. 3.48 Heat map-nature. From S.M
Page 183 and 184:
Fig. 3.51 Prostate cancer. Major su
Page 185 and 186:
many stage T1b cancers. Stage T2 Mo
Page 187 and 188:
Fig. 3.58 Patterns of seminal vesic
Page 189 and 190:
Prostatic intraepithelial neoplasia
Page 191 and 192:
A B Fig. 3.63 A Micropapillary high
Page 193 and 194:
A B Fig. 3.68 A Ductal carcinoma in
Page 195 and 196:
Ductal adenocarcinoma X.J. Yang L.
Page 197 and 198:
Papillary pattern can be seen in bo
Page 199 and 200:
A B Fig. 3.74 A Inflammation withou
Page 201 and 202:
Squamous neoplasms T.H. Van der Kwa
Page 203 and 204:
Neuroendocrine tumours P.A. di Sant
Page 205 and 206:
Mesenchymal tumours J. Cheville F.
Page 207 and 208:
Fig. 3.89 Sarcoma of the prostate.
Page 209 and 210:
Miscellaneous tumours P.H. Tan L. C
Page 211 and 212:
A Fig. 3.96 A Adenocarcinoma of the
Page 213 and 214:
WHO histological classification of
Page 215 and 216:
Introduction F.K. Mostofi I.A. Sest
Page 217 and 218:
wartime birth cohorts illustrate th
Page 219 and 220:
Similar tumours as those of group 1
Page 221 and 222:
crucial for the development of this
Page 223 and 224:
A B Fig. 4.09 Spermatocytic seminom
Page 225 and 226:
A B Fig. 4.14 Intratubular germ cel
Page 227 and 228:
A B Fig. 4.19 Seminoma. A Typical s
Page 229 and 230:
Fig. 4.24 Seminoma. Vascular invasi
Page 231 and 232:
Fig. 4.28 Spermatocytic seminoma wi
Page 233 and 234:
A B Fig. 4.33 Embryonal carcinoma.
Page 235 and 236:
A B Fig. 4.38 Yolk sac tumour. A En
Page 237 and 238:
have cytoplasmic lacunae that conta
Page 239 and 240:
A Fig. 4.46 Teratoma. A Longitudina
Page 241 and 242:
A B Fig. 4.51 A Cut surface of derm
Page 243 and 244:
Fig. 4.54 Mixed germ cell tumour. L
Page 245 and 246:
Sex cord / gonadal stromal tumours
Page 247 and 248:
A B C Fig. 4.67 Malignant Leydig ce
Page 249 and 250:
A Fig. 4.73 A Sertoli cell tumour.
Page 251 and 252:
ICD-O codes Granulosa cell tumour 8
Page 253 and 254:
ICD-O code 8592/1 Clinical features
Page 255 and 256:
A B Fig. 4.83 Germ cell-sex cord/go
Page 257 and 258:
A Fig. 4.85 A, B Brenner tumour of
Page 259 and 260:
typical grade III follicular morpho
Page 261 and 262:
testicular parenchyma and tumour te
Page 263 and 264:
A B the surgical scar and adjacent
Page 265 and 266: Immunoprofile Ordóñez and associa
Page 267 and 268: often have a grey-white cut surface
Page 269 and 270: Fig. 4.111 Angiomyofibroblastoma-li
Page 271 and 272: A B Fig. 4.119 Embryonal rhabdomyos
Page 273 and 274: Table 4.05 Secondary tumours of the
Page 275 and 276: WHO histological classification of
Page 277 and 278: A Fig. 5.04 A, B Squamous cell carc
Page 279 and 280: deformed by an exophytic mass. In s
Page 281 and 282: A B C Fig. 5.12 A Warty (condylomat
Page 283 and 284: A Fig. 5.20 Bowenoid papulosis. A,
Page 285 and 286: three had been circumcized by 9 yea
Page 287 and 288: Mesenchymal tumours J.F. Fetsch M.
Page 289 and 290: Fig. 5.31 Neurofibroma of the penis
Page 291 and 292: oectodermal tumour/Ewing sarcoma [p
Page 293 and 294: Secondary tumours of the penis C.J.
Page 295 and 296: Dr John N. EBLE* Dept. of Pathology
Page 297 and 298: Dr Ricardo PANIAGUA Department of C
Page 299 and 300: Source of charts and photographs 1.
Page 301 and 302: References 1. Anon. (1955). Case re
Page 303 and 304: 115. Ariel I, Sughayer M, Fellig Y,
Page 305 and 306: 246. Birt AR, Hogg GR, Dube WJ (197
Page 307 and 308: 374. Cardone G, Malventi M, Roffi M
Page 309 and 310: 502. Corti B, Carella R, Gabusi E,
Page 311 and 312: 633. Donhuijsen K, Schmidt U, Richt
Page 313 and 314: 768. Fischer J, Palmedo G, von Knob
Page 315: 900. Goedert JJ, Cote TR, Virgo P,
Page 319 and 320: 1162. Iezzoni JC, Fechner RE, Wong
Page 321 and 322: 1293. Keetch DW, Catalona WJ (1995)
Page 323 and 324: 1424. Ladanyi M, Lui MY, Antonescu
Page 325 and 326: 1548. Lopez-Beltran A, Croghan GA,
Page 327 and 328: 1681. McLaughlin JK, Silverman DT,
Page 329 and 330: 1816. Moudouni SM, En-Nia I, Rioux-
Page 331 and 332: 1945. Ohori M, Wheeler TM, Kattan M
Page 333 and 334: 2070. Phillips G, Kumari-Subaiya S,
Page 335 and 336: 2199. Riou G, Barrois M, Prost S, T
Page 337 and 338: 2327. Schmidt L, Junker K, Weirich
Page 339 and 340: 2450. Smith G, Elton RA, Beynon LL,
Page 341 and 342: 2572. Tamboli P, Mohsin SK, Hailema
Page 343 and 344: 2693. van Echten J, Timmer A, van d
Page 345 and 346: 2816. Wick MR, Berg LC, Hertz MI (1
Page 347 and 348: 2937. Zhuang Z, Park WS, Pack S, Sc
Page 349 and 350: CCNB, 226 CCND1, 105, 108 CCND2, 22
Page 351 and 352: J Juvenile type granulosa cell tumo
Page 353 and 354: Promoter methylation, 21 Prostate s
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Eble JN, Sauter G., Epstein JI, Sesterhenn IA - iarc

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