Thesis final - after defense-7 - Jacobs University

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References 5. References 1. Singh, B.D. Biotechnology: expanding horizons. Kalyani: 2008. 2. Ratledge, C. and Kristiansen, B. Basic biotechnology. Cambridge <strong>University</strong> Press: 2006. 3. Pavlou, A.K. and Reichert, J.M. Recombinant protein therapeutics-success rates, market trends and values to 2010. Nature Biotechnology 2004, 22, 1513-1519. 4. Harrison, R.G. Bioseparations science and engineering: 2003. 5. Headon, D.R. and Walsh, G. The industrial production of enzymes. Biotechnology Advances 1994, 12, 635-646. 6. Wiseman, A. Designer enzyme and cell applications in industry and in environmental monitoring. Journal of Chemical Technology and Biotechnology 1993, 56, 3-13. 7. Labrou, N. and Clonis, Y.D. The affinity technology in downstream processing. Journal of Biotechnology 1994, 36, 95-119. 8. Wheelwright, S.M. Protein purification: design and scale up of downstream processing: 1991. 9. Lienqueo, M.E. and Asenjo, J.A. Use of expert systems for the synthesis of downstream protein processes. Computers & Chemical Engineering 2000, 24, 2339-2350. 10. Hooker, B.S. and Lee, J.M. Application of a new structured model to tobacco cell cultures. Biotechnology and bioengineering 1992, 39, 765-774. 11. Asenjo, J.A.; Herrera, L.; Byrne, B. Development of an expert system for selection and synthesis of protein purification processes. Journal of Biotechnology 1989, 11, 275-298. 12. Eriksson, H.; Sandahl, K.; Brewer, J.; Osterlund, B. Reactive planning for chromatography. Chemometrics and Intelligent Laboratory Systems 1991, 13, 185-194. 117
References 13. Lienqueo, M.E.; Leser, E.W.; Asenjo, J.A. An Expert System for the selection and synthesis of multistep protein separation processes. Computers & Chemical Engineering 1996, 20, Supplement 1, S189-S194. 14. Buydens, L.M.C.; van Leeuwen, J.A.; Mulholland, M.; Vandeginste, B.G.M.; Kateman, G. An expert system for the validation of high-performance liquid chromatographic methods. TrAC Trends in Analytical Chemistry 1990, 9, 58-62. 15. Scott M., W. The design of downstream processes for large-scale protein purification. Journal of Biotechnology 1989, 11, 89-102. 16. Watanabe, E.; Tsoka, S.; Asenjo, J.A. Selection of chromatographic protein purification operations based on physicochemical properties. Annals of the New York Academy of Sciences 1994, 721, 348-364. 17. Lowe, C.R.; Lowe, A.R.; Gupta, G. New developments in affinity chromatography with potential application in the production of biopharmaceuticals. Journal of Biochemical and Biophysical Methods 2001, 49, 561-574. 18. Novais, J.L.; Titchener-Hooker, N.; Hoare, M. Economic comparison between conventional and disposables-based technology for the production of biopharmaceuticals. Biotechnology and bioengineering 2001, 75, 143-153. 19. Cabrera, R. and Fernandez-Lahore, M. Global screening of protein chromatographic behavior on ion exchangers from a complex cell proteome: Towards in silico downstream processing of bioproducts. Journal of Chromatography A 2007, 1161, 41-50. 20. GE healthcare Hydrophobic interactions and reverse phase chromatography Principles and methods hand book 11-0012-69AA. 21. Vailaya, A. and Horvath, C. Retention thermodynamics in hydrophobic interaction chromatography. Industrial & Engineering Chemistry Research 1996, 35, 2964-2981. 22. Ceccaroli, P.; Cardoni, P.; Buffalini, M.; De Bellis, R.; Piccoli, G.; Stocchi, V. Separation of hexokinase activity using different hydrophobic interaction supports. Journal of Chromatography B: Biomedical Sciences and Applications 1997, 702, 41-48. 118
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A proteome wide approach to underst
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I also want to mention the efforts
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Dedication To my father Haji Sher A
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Table of Contents 1. Introduction .
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3.3.2.2. Protein distributions on 2
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Chapter 1 1. Introduction 1.1. Intr
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Chapter 1 cell proteome to facilita
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Chapter 1 proteins. It is this diff
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Chapter 1 Salt conc. decreasing (Gr
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Chapter 1 The ions at the start of
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Chapter 1 exposure of hydrophobic r
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Chapter 1 based on the surface hydr
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Chapter 1 1.5. Analysis of the yeas
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Chapter 1 molecular weight impuriti
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Chapter 1 followed by its introduct
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Chapter 1 protein towards purificat
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Chapter 2 EXPERIMENTAL APPROACH
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Chapter 2 Yeast cell proteome and c
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Chapter 2 ligands (Toyopearl-Hexyl,
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Chapter 2 number of spots was count
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Chapter 2 (http://www.matrixscience
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Chapter 3 RESULTS AND DISCUSSION
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Chapter 3 to the retention behavior
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Chapter 3 investigate the hydrophob
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Chapter 3 the interior of the prote
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Chapter 3 A B C Figure 9: The cryst
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Chapter 3 of the comparative analys
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Chapter 3 Figure 11: Represent the
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Chapter 3 Ether, some 2-D gels were
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Chapter 3 Figure 13: Represent 2-D
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Chapter 3 Table 5. List of the iden
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Chapter 3 Table 7. List of the iden
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Chapter 3 amino acids by Cowan-Whit
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Chapter 3 Figure 15 C: Represents t
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Chapter 3 Figure 16 A: Represents t
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Chapter 3 The polarity value for th
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Chapter 3 Figure 17: Represents the
Page 75 and 76: Chapter 3 Figure 18: Represents the
Page 77 and 78: Chapter 3 published papers with mod
Page 79 and 80: Chapter 3 ligands revealed less dif
Page 81 and 82: Chapter 3 3.2. Influence of the dif
Page 83 and 84: Chapter 3 Table 10: The chemistry o
Page 85 and 86: Chapter 3 where approximately 50% o
Page 87 and 88: Chapter 3 3.2.3.2. The electrophore
Page 89 and 90: Chapter 3 Figure 22: Represent 2-D
Page 91 and 92: Chapter 3 Table 12. List of the ide
Page 93 and 94: Chapter 3 Table 14. List of the ide
Page 95 and 96: Chapter 3 r 2 values from the data
Page 97 and 98: Chapter 3 Figure 24 C: Represents t
Page 99 and 100: Chapter 3 approximately 47%. The me
Page 101 and 102: Chapter 3 Figure 25 B: Represents t
Page 103 and 104: Chapter 3 values have been reported
Page 105 and 106: Chapter 3 towards conformational ch
Page 107 and 108: Chapter 3 Figure 28: Represents the
Page 109 and 110: Chapter 3 among the adsorbents were
Page 111 and 112: Chapter 3 3.3. Protein distribution
Page 113 and 114: Chapter 3 3.3.2.2. Protein distribu
Page 115 and 116: Chapter 3 Figure 29 B: Represent th
Page 117 and 118: Chapter 3 When the number of smalle
Page 119 and 120: Chapter 3 and hydrophobic interacti
Page 121 and 122: Chapter 4 CONCLUSIONS
Page 123 and 124: Chapter 4 • The base supports rev
Page 125: Chapter 4 additional understanding
Page 129 and 130: References 32. Salgado, J.C.; Rapap
Page 131 and 132: References 52. B.H.J., H. Accessibl
Page 133 and 134: References 71. Xindu, G. and Regnie
Page 135 and 136: References 91. Alonso-Orgaz, S.; Mo
Page 137 and 138: References 112. Gu, Z. and Glatz, C
Page 139: References 132. Reubsaet, J.L.E. an
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