Thesis final - after defense-7 - Jacobs University

Chapter 3
Figure 17: Represents the average flexibility calculated by Bhaskaran and Ponnuswamy’s scale.
The protein average flexibility values of the three ligands were correlated with the respective
salt concentrations where the fractions were collected. The error bars represent the standard
deviations of the average flexibility values in each fraction. The statistical analysis revealed a
significant correlation (r 2 = 0.80; p < 0.0001).
The flexibility and stability of the proteins were also reported for their applications in nature,
where the organisms stay alive at -50°C to over 100°C. All the organisms have the same 20
amino acids; however it could be the combine contribution of the amino acid residues
balancing the stability and flexibility of proteins and allowing the organism to stay on both
temperature extremes (120). The average flexibility has shown no relation to the molecular
weight and isoelectric point values of the proteins. In other words, the flexibility values of the
tabulated proteins were independent of whether a protein is larger or smaller and acidic or
basic in nature. The flexibility has revealed a direct relationship with the protein retention
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