in vitro PHARMACOLOGY 2011 CATALOG - Cerep
in vitro PHARMACOLOGY 2011 CATALOG - Cerep
in vitro PHARMACOLOGY 2011 CATALOG - Cerep
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111<br />
prote<strong>in</strong>-tyros<strong>in</strong>e k<strong>in</strong>ases [Rtk] ❚<br />
EphA7 k<strong>in</strong>ase<br />
Ref. 3058<br />
Q 3 weeks<br />
Included <strong>in</strong>:<br />
Comprehensive k<strong>in</strong>ase profile<br />
Source<br />
human recomb<strong>in</strong>ant<br />
Substrate<br />
ATP + Ulight-TK peptide<br />
(100 nM)<br />
Measured product phospho-Ulight-TK peptide<br />
Detection method LANCE<br />
Reference<br />
staurospor<strong>in</strong>e (IC 50 : 130 nM)<br />
Hafner, C. et al. (2004) Cl<strong>in</strong>. Chem., 50: 490-499.<br />
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<strong>Cerep</strong><br />
services<br />
Receptors<br />
EphA8 k<strong>in</strong>ase<br />
Ref. 3072<br />
Q 3 weeks<br />
Source<br />
human recomb<strong>in</strong>ant<br />
Substrate<br />
ATP + Ulight-TK peptide<br />
(100 nM)<br />
Measured product phospho-Ulight-TK peptide<br />
Detection method LANCE<br />
Reference<br />
staurospor<strong>in</strong>e (IC 50 : 140 nM)<br />
Park, S. (2003) J. Biochem. Mol. Biol., 36: 288-293.<br />
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Ion<br />
channels<br />
Transporters<br />
EphB1 k<strong>in</strong>ase<br />
Ref. 3053<br />
Q 3 weeks<br />
Included <strong>in</strong>:<br />
Comprehensive k<strong>in</strong>ase profile<br />
Source<br />
human recomb<strong>in</strong>ant<br />
Substrate<br />
ATP + Ulight-TK peptide<br />
(50 nM)<br />
Measured product phospho-Ulight-TK peptide<br />
Detection method LANCE<br />
Reference<br />
staurospor<strong>in</strong>e (IC 50 : 81.3 nM)<br />
V<strong>in</strong>dis, C. et al. (2003) J. Cell. Biol., 162: 661-671.<br />
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K<strong>in</strong>ases<br />
Epigenetic &<br />
DNA-related<br />
enzymes<br />
EphB2 k<strong>in</strong>ase<br />
Ref. 3054<br />
Q 3 weeks<br />
Included <strong>in</strong>:<br />
Organ safety profile<br />
Comprehensive k<strong>in</strong>ase profile<br />
Source<br />
human recomb<strong>in</strong>ant<br />
Substrate<br />
ATP + Ulight-TK peptide<br />
(50 nM)<br />
Measured product phospho-Ulight-TK peptide<br />
Detection method LANCE<br />
Reference<br />
PP2 (IC 50 : 95.7 nM)<br />
B<strong>in</strong>ns, K.L. et al. (2000) Mol. Cell. Biol., 20: 4791-4805.<br />
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Other<br />
enzymes<br />
Specialized<br />
cellular<br />
assays<br />
EphB3 k<strong>in</strong>ase<br />
Ref. 2731<br />
Q 3 weeks<br />
Included <strong>in</strong>:<br />
Comprehensive k<strong>in</strong>ase profile<br />
Source<br />
human recomb<strong>in</strong>ant<br />
Substrate<br />
ATP + Ulight-Poly GAT[EAY(1:1:1)]n<br />
(5 nM)<br />
Measured product phospho-Ulight-Poly GAT[EAY(1:1:1)]n<br />
Detection method LANCE<br />
Reference<br />
PP2 (IC 50 : 400 nM)<br />
Bembenek, M.E. et al. (2003) Assay Drug Dev. Technol., 1: 555-563.<br />
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Standard<br />
profiles<br />
Test<strong>in</strong>g<br />
conditions<br />
EphB4 k<strong>in</strong>ase<br />
Ref. 3059<br />
Q 3 weeks<br />
Included <strong>in</strong>:<br />
ExpresS Diversity k<strong>in</strong>ase profile<br />
Organ safety profile<br />
Comprehensive k<strong>in</strong>ase profile<br />
Source<br />
human recomb<strong>in</strong>ant (<strong>in</strong>sect cells)<br />
Substrate<br />
ATP + Ulight-TK peptide<br />
(100 nM)<br />
Measured product phospho-Ulight-TK peptide<br />
Detection method LANCE<br />
Reference<br />
staurospor<strong>in</strong>e (IC 50 : 300 nM)<br />
Sturz, A. et al. (2004) Biochem. Biophys. Res. Commun., 313: 80-88.<br />
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Order<strong>in</strong>g<br />
<strong>in</strong>formation<br />
Assay list<br />
& <strong>in</strong>dex
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