in vitro PHARMACOLOGY 2011 CATALOG - Cerep
in vitro PHARMACOLOGY 2011 CATALOG - Cerep
in vitro PHARMACOLOGY 2011 CATALOG - Cerep
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149<br />
❚ prote<strong>in</strong>-SERINE/THREONINE k<strong>in</strong>ases [TKL]<br />
<strong>Cerep</strong><br />
services<br />
ALK4 (ACVR1B)<br />
Ref. 3268<br />
Q 3 weeks<br />
Included <strong>in</strong>:<br />
Comprehensive k<strong>in</strong>ase profile<br />
Source<br />
human recomb<strong>in</strong>ant<br />
Substrate ATP + Ulight-DNA topoisomerase 2a<br />
(50 nM)<br />
Measured product phospho-Ulight-DNA topoisomerase 2a<br />
Detection method LANCE<br />
Reference<br />
staurospor<strong>in</strong>e (IC 50 : 148 nM)<br />
Lap<strong>in</strong>g, N.J. et al.(2002) Mol. Pharmacol., 62: 58-64.<br />
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Receptors<br />
Ion<br />
channels<br />
BMPR1A k<strong>in</strong>ase (ALK3)<br />
Ref. 2762<br />
Q 3 weeks<br />
Included <strong>in</strong>:<br />
Comprehensive k<strong>in</strong>ase profile<br />
Source<br />
human recomb<strong>in</strong>ant<br />
Substrate ATP + Ulight-ARTKQTARKSTGGKAPRKQLAGCG<br />
(25 nM)<br />
Measured product phospho-Ulight-ARTKQTARKSTGGKAPRKQL<br />
AGCG<br />
Detection method LANCE<br />
Reference staurospor<strong>in</strong>e (IC 50 : 148 nM)<br />
Zhou, X.P. et al. (2001) Am. J. Hum. Genet., 69: 704-711.<br />
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Transporters<br />
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K<strong>in</strong>ases<br />
B-raf k<strong>in</strong>ase<br />
Ref. 3294<br />
Q 3 weeks<br />
Included <strong>in</strong>:<br />
Organ safety profile<br />
Comprehensive k<strong>in</strong>ase profile<br />
Source<br />
human recomb<strong>in</strong>ant<br />
Substrate ATP + <strong>in</strong>active MEK1<br />
(15 nM)<br />
Measured product phospho-<strong>in</strong>active MEK1<br />
Detection method LANCE<br />
Reference<br />
Raf-1 <strong>in</strong>hibitor (IC 50 : 213 nM)<br />
Kupcho, K.R. et al.(2008) Curr. Chem. Genomics., 1: 43-53.<br />
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Epigenetic &<br />
DNA-related<br />
enzymes<br />
Other<br />
enzymes<br />
DLK1 (MAP3K12)<br />
Ref. 2620<br />
Q 3 weeks<br />
Included <strong>in</strong>:<br />
Organ safety profile<br />
Comprehensive k<strong>in</strong>ase profile<br />
Source<br />
human recomb<strong>in</strong>ant<br />
Substrate ATP + CREBtide (CKRREILSRRPSYRK)<br />
(25 nM)<br />
Measured product phospho-CREBtide (CKRREILSRRPSYRK)<br />
Detection method LANCE<br />
Reference<br />
staurospor<strong>in</strong>e (IC 50 : 2.36 nM)<br />
Robitaille, H. et al. (2005) J. Biol. Chem., 280: 12732-12741.<br />
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Specialized<br />
cellular<br />
assays<br />
Standard<br />
profiles<br />
IRAK1<br />
Ref. 1968<br />
Q 3 weeks<br />
Included <strong>in</strong>:<br />
Comprehensive k<strong>in</strong>ase profile<br />
Source<br />
human recomb<strong>in</strong>ant (<strong>in</strong>sect cells)<br />
Substrate ATP + Ulight-FLGFTYVAP<br />
(200 nM)<br />
Measured product phospho-Ulight-FLGFTYVAP<br />
Detection method LANCE<br />
Reference<br />
staurospor<strong>in</strong>e (IC 50 : 43.5 nM)<br />
Huang, Y. et al. (2004) J. Biol. Chem., 279: 51697-51703.<br />
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Test<strong>in</strong>g<br />
conditions<br />
Order<strong>in</strong>g<br />
<strong>in</strong>formation<br />
For further details and updated <strong>in</strong>formation on assays:<br />
❚ Please go to www.cerep.com catalog onl<strong>in</strong>e or contact us at sales@cerep.com<br />
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❚ Europe: +33 (0)5 49 89 30 00 – USA: +1 (425) 895 8666 – Japan: +81 (0)3 3354 4026 – Ch<strong>in</strong>a: +86 21 5132 0568<br />
Assay developed <strong>in</strong> 2010 New assay conditions and/or assay converted from HTRF ® to LANCEUltra ®<br />
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<br />
Human Q Standard turnaround time<br />
Assay list<br />
& <strong>in</strong>dex
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