in vitro PHARMACOLOGY 2011 CATALOG - Cerep
in vitro PHARMACOLOGY 2011 CATALOG - Cerep
in vitro PHARMACOLOGY 2011 CATALOG - Cerep
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154 <strong>in</strong> <strong>vitro</strong> pharmacology <strong>2011</strong> catalog<br />
❚ other k<strong>in</strong>ases<br />
PEK (EIF2AK3)<br />
Ref. 2589<br />
Q 3 weeks<br />
Included <strong>in</strong>:<br />
Comprehensive k<strong>in</strong>ase profile<br />
Source<br />
human recomb<strong>in</strong>ant<br />
Substrate ATP + Ulight-FLGFTYVAP<br />
(40 nM)<br />
Measured product phospho-Ulight-FLGFTYVAP<br />
Detection method LANCE<br />
Reference<br />
staurospor<strong>in</strong>e (IC 50 : 2.28 µM)<br />
Wek, R.C. et al. (2006) Bioch. Soc. Trans., 34: part 1.<br />
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PKR (EIF2AK2)<br />
Ref. 2522<br />
Q 3 weeks<br />
Included <strong>in</strong>:<br />
Comprehensive k<strong>in</strong>ase profile<br />
Source<br />
human recomb<strong>in</strong>ant<br />
Substrate ATP + Ulight-ARTKQTARKSTGGKAPRKQLAGCG<br />
(25 nM)<br />
Measured product phospho-Ulight-ARTKQTARKSTGGKAPRKQL<br />
AGCG<br />
Detection method LANCE<br />
Reference<br />
staurospor<strong>in</strong>e (IC 50 : 420 nM)<br />
Kim, S.H. et al. (2000) Oncogene, 19: 3086-3094.<br />
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PLK1<br />
Ref. 2049<br />
Q 3 weeks<br />
Included <strong>in</strong>:<br />
ExpresS Diversity k<strong>in</strong>ase profile<br />
Comprehensive k<strong>in</strong>ase profile<br />
Source<br />
human recomb<strong>in</strong>ant<br />
Substrate ATP + Ulight-FLGFTYVAP<br />
(40 nM)<br />
Measured product phospho-Ulight-FLGFTYVAP<br />
Detection method LANCE<br />
Reference<br />
staurospor<strong>in</strong>e (IC 50 : 427 nM)<br />
Golsteyn, R.M. et al. (1995) J. Cell. Biol., 129: 1617-1628.<br />
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PLK2<br />
Ref. 2766<br />
Q 3 weeks<br />
Included <strong>in</strong>:<br />
Comprehensive k<strong>in</strong>ase profile<br />
Source<br />
human recomb<strong>in</strong>ant<br />
Substrate ATP + Ulight-FLGFTYVAP<br />
(200 nM)<br />
Measured product phospho-Ulight-FLGFTYVAP<br />
Detection method LANCE<br />
Reference<br />
staurospor<strong>in</strong>e (IC 50 : 355 nM)<br />
Inglis, K.J. et al. (2009) J. Biol. Chem., 284: 2598-2602.<br />
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PLK3<br />
Ref. 2793<br />
Q 3 weeks<br />
Source<br />
human recomb<strong>in</strong>ant<br />
Substrate ATP + Ulight-CGSGSGRPRTSSFAEG<br />
(50 µM)<br />
Measured product phospho-Ulight-CGSGSGRPRTSSFAEG<br />
Detection method LANCE<br />
Reference<br />
wortmann<strong>in</strong> (IC 50 : 130 nM)<br />
Liu, Y. et al. (2007) J. Biol. Chem., 282: 2505-2511.<br />
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PLK4<br />
Ref. 2749<br />
Q 3 weeks<br />
Included <strong>in</strong>:<br />
Comprehensive k<strong>in</strong>ase profile<br />
Source<br />
human recomb<strong>in</strong>ant<br />
Substrate ATP + CREBtide (CKRREILSRRPSYRK)<br />
(25 nM)<br />
Measured product phospho-CREBtide (CKRREILSRRPSYRK)<br />
Detection method LANCE<br />
Reference<br />
staurospor<strong>in</strong>e (IC 50 : 13 nM)<br />
Liu, Y. et al. (2007) J. Biol. Chem., 282: 2505-2511.
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