in vitro PHARMACOLOGY 2011 CATALOG - Cerep
in vitro PHARMACOLOGY 2011 CATALOG - Cerep
in vitro PHARMACOLOGY 2011 CATALOG - Cerep
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155<br />
other k<strong>in</strong>ases ❚<br />
TBK1<br />
Ref. 3347<br />
Q 3 weeks<br />
Included <strong>in</strong>:<br />
Comprehensive k<strong>in</strong>ase profile<br />
Source<br />
human recomb<strong>in</strong>ant (Sf9 cells)<br />
Substrate ATP + Ulight-FLGFTYVAP<br />
(200 nM)<br />
Measured product phospho-Ulight-FLGFTYVAP<br />
Detection method LANCE<br />
Reference<br />
staurospor<strong>in</strong>e (IC 50 : 16 nM)<br />
Clark K. et al.(2009) J. Biol. Chem., 284: 14136-14146.<br />
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<strong>Cerep</strong><br />
services<br />
Receptors<br />
TTK<br />
Ref. 2767<br />
Q 3 weeks<br />
Included <strong>in</strong>:<br />
Comprehensive k<strong>in</strong>ase profile<br />
Source<br />
human recomb<strong>in</strong>ant<br />
Substrate ATP + Ulight-ARTKQTARKSTGGKAPRKQLAGCG<br />
(25 nM)<br />
Measured product phospho-Ulight-ARTKQTARKSTGGKAPRKQL<br />
AGCG<br />
Detection method LANCE<br />
Reference<br />
staurospor<strong>in</strong>e (IC 50 : 400 nM)<br />
Mills, G.B. et al. (1992) J. Biol. Chem., 267: 16000-16006.<br />
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Ion<br />
channels<br />
Transporters<br />
ULK1<br />
Ref. 3346<br />
Q 3 weeks<br />
Included <strong>in</strong>:<br />
Comprehensive k<strong>in</strong>ase profile<br />
Source<br />
human recomb<strong>in</strong>ant (Sf9 cells)<br />
Substrate ATP + Ulight-FLGFTYVAP<br />
(200 nM)<br />
Measured product phospho-Ulight-FLGFTYVAP<br />
Detection method LANCE<br />
Reference<br />
staurospor<strong>in</strong>e (IC 50 : 24 nM)<br />
Jung, C.H. et al.(2009) Mol. Bio. Cell., 20: 1992-2003.<br />
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K<strong>in</strong>ases<br />
Epigenetic &<br />
DNA-related<br />
enzymes<br />
ULK2<br />
Ref. 3348<br />
Q 3 weeks<br />
Source<br />
human recomb<strong>in</strong>ant (Sf21 cells)<br />
Substrate ATP + Ulight-FLGFTYVAP<br />
(150 nM)<br />
Measured product phospho-Ulight-FLGFTYVAP<br />
Detection method LANCE<br />
Reference<br />
staurospor<strong>in</strong>e (IC 50 : 6.4 nM)<br />
Jung, C.H. et al.(2009) Mol. Bio. Cell., 20: 1992-2003.<br />
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Other<br />
enzymes<br />
Specialized<br />
cellular<br />
assays<br />
Wee1 k<strong>in</strong>ase<br />
Ref. 2940<br />
Q 3 weeks<br />
Included <strong>in</strong>:<br />
Comprehensive k<strong>in</strong>ase profile<br />
WNK2<br />
Ref. 2768<br />
Q 3 weeks<br />
Included <strong>in</strong>:<br />
Comprehensive k<strong>in</strong>ase profile<br />
Source<br />
human recomb<strong>in</strong>ant (<strong>in</strong>sect cells)<br />
Substrate ATP + Ulight-ARTKQTARKSTGGKAPRKQLAGCG<br />
(25 nM)<br />
Measured product phospho-Ulight-ARTKQTARKSTGGKAPRKQL<br />
AGCG<br />
Detection method LANCE<br />
Reference staurospor<strong>in</strong>e (IC 50 : 150 nM)<br />
Yoshida, T. et al. (2004) Annal. Oncol., 15: 252-256.<br />
Source<br />
human recomb<strong>in</strong>ant<br />
Substrate ATP + Ulight-ARTKQTARKSTGGKAPRKQLAGCG<br />
(50 nM)<br />
Measured product phospho-Ulight-ARTKQTARKSTGGKAPRKQL<br />
AGCG<br />
Detection method LANCE<br />
Reference<br />
staurospor<strong>in</strong>e (IC 50 : 455 nM)<br />
Richardson, C. and Alessi, D.R. (2008) J. Cell. Sci., 121: 3293-3304.<br />
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Standard<br />
profiles<br />
Test<strong>in</strong>g<br />
conditions<br />
Order<strong>in</strong>g<br />
<strong>in</strong>formation<br />
Assay list<br />
& <strong>in</strong>dex
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