in vitro PHARMACOLOGY 2011 CATALOG - Cerep
in vitro PHARMACOLOGY 2011 CATALOG - Cerep
in vitro PHARMACOLOGY 2011 CATALOG - Cerep
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JAK1<br />
Ref. 2619<br />
Q 3 weeks<br />
Included <strong>in</strong>:<br />
Organ safety profile<br />
Comprehensive k<strong>in</strong>ase profile<br />
Source<br />
human recomb<strong>in</strong>ant<br />
Substrate<br />
ATP + Ulight-CAGAGAIETDKEYYTVKD<br />
(100 nM)<br />
Measured product phospho-Ulight-CAGAGAIETDKEYYTVKD<br />
Detection method LANCE<br />
Reference<br />
staurospor<strong>in</strong>e (IC 50 : 1.6 nM)<br />
Yamaoka, K. et al. (2004) Gen. Biol., 5: 253.<br />
prote<strong>in</strong>-tyros<strong>in</strong>e k<strong>in</strong>ases [Ctk] ❚<br />
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<strong>Cerep</strong><br />
services<br />
Receptors<br />
JAK2<br />
Ref. 2869<br />
Q 3 weeks<br />
Included <strong>in</strong>:<br />
Organ safety profile<br />
Comprehensive k<strong>in</strong>ase profile<br />
Source<br />
human recomb<strong>in</strong>ant (Sf21 cells)<br />
Substrate<br />
ATP + Ulight-CAGAGAIETDKEYYTVKD<br />
(100 nM)<br />
Measured product phospho-Ulight-CAGAGAIETDKEYYTVKD<br />
Detection method LANCE<br />
Reference<br />
staurospor<strong>in</strong>e (IC 50 : 1.5 nM)<br />
Brizzi, M.F. et al. (1996) J. Biol. Chem., 271: 3562-3567.<br />
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Ion<br />
channels<br />
Transporters<br />
JAK3<br />
Ref. 2905<br />
Q 3 weeks<br />
Included <strong>in</strong>:<br />
ExpresS Diversity k<strong>in</strong>ase profile<br />
Comprehensive k<strong>in</strong>ase profile<br />
Source<br />
human recomb<strong>in</strong>ant<br />
Substrate<br />
ATP + Ulight-CAGAGAIETDKEYYTVKD<br />
(100 nM)<br />
Measured product phospho-Ulight-CAGAGAIETDKEYYTVKD<br />
Detection method LANCE<br />
Reference<br />
staurospor<strong>in</strong>e (IC 50 : 0.77 nM)<br />
Zhou, Y.-J. et al. (1997) Proc. Natl. Acad. Sci. U.S.A., 94: 13850-13855.<br />
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K<strong>in</strong>ases<br />
Epigenetic &<br />
DNA-related<br />
enzymes<br />
Lck k<strong>in</strong>ase<br />
Ref. 2906<br />
Q 3 weeks<br />
Included <strong>in</strong>:<br />
ExpresS Diversity k<strong>in</strong>ase profile<br />
Comprehensive k<strong>in</strong>ase profile<br />
Source<br />
human recomb<strong>in</strong>ant (<strong>in</strong>sect cells)<br />
Substrate<br />
ATP + Ulight-Poly GAT[EAY(1:1:1)]n<br />
(25 nM)<br />
Measured product phospho-Ulight-Poly GAT[EAY(1:1:1)]n<br />
Detection method LANCE<br />
Reference<br />
staurospor<strong>in</strong>e (IC 50 : 31 nM)<br />
Park, Y.M. et al. (1999) Anal. Biochem., 269: 94-104.<br />
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Other<br />
enzymes<br />
Specialized<br />
cellular<br />
assays<br />
Lyn A k<strong>in</strong>ase<br />
Ref. 0669<br />
Q 3 weeks<br />
Included <strong>in</strong>:<br />
BioPr<strong>in</strong>t ® profile<br />
Comprehensive k<strong>in</strong>ase profile<br />
Source<br />
human recomb<strong>in</strong>ant (<strong>in</strong>sect cells)<br />
Substrate<br />
ATP +biot<strong>in</strong>yl-βAβAβAKVEKIGEGTYGVVYK<br />
(400 nM)<br />
Measured product phospho-biot<strong>in</strong>yl-AβAβAKVEKIGEGTYGVVYK<br />
Detection method HTRF<br />
Reference<br />
staurospor<strong>in</strong>e (IC 50 : 18 nM)<br />
Cheng, H.C. et al. (1992) J. Biol. Chem., 267: 9248-9256.<br />
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Standard<br />
profiles<br />
Test<strong>in</strong>g<br />
conditions<br />
Lyn B k<strong>in</strong>ase<br />
Ref. 2201<br />
Q 3 weeks<br />
Included <strong>in</strong>:<br />
Comprehensive k<strong>in</strong>ase profile<br />
Source<br />
human recomb<strong>in</strong>ant (<strong>in</strong>sect cells)<br />
Substrate<br />
ATP + His-tagged Rb truncated prote<strong>in</strong><br />
(70 nM)<br />
Measured product phospho-His-tagged Rb truncated prote<strong>in</strong><br />
Detection method HTRF<br />
Reference<br />
staurospor<strong>in</strong>e (IC 50 : 11.6 nM)<br />
Yi, T.L. et al. (1991) Mol. Cell. Biol., 11: 2391-2398.<br />
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Order<strong>in</strong>g<br />
<strong>in</strong>formation<br />
Assay list<br />
& <strong>in</strong>dex
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