in vitro PHARMACOLOGY 2011 CATALOG - Cerep
in vitro PHARMACOLOGY 2011 CATALOG - Cerep
in vitro PHARMACOLOGY 2011 CATALOG - Cerep
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84 <strong>in</strong> <strong>vitro</strong> pharmacology <strong>2011</strong> catalog<br />
❚ cytok<strong>in</strong>es<br />
IL-1b - agonist radioligand<br />
b<strong>in</strong>d<strong>in</strong>g<br />
Ref. 0073<br />
[Custom offer]<br />
Please contact us at:<br />
customresearch@cerep.com<br />
Source<br />
Ligand<br />
Kd<br />
Non specific<br />
Reference<br />
Balb/c 3T3 cells<br />
[ 125 I]IL-1β (0.1 nM)<br />
0.49 nM<br />
IL-1β (10 nM)<br />
IL-1β (IC 50 : 0.06 nM)<br />
Bird, T.A. et al. (1987) FEBS Lett., 225: 21-26.<br />
specific b<strong>in</strong>d<strong>in</strong>g (% of control)<br />
100<br />
50<br />
0<br />
-11 -10 -9 -8 -7<br />
log [drug] (M)<br />
IL-1β<br />
IL-1α<br />
TNF-α<br />
IL-2 - agonist radioligand<br />
b<strong>in</strong>d<strong>in</strong>g<br />
Ref. 0353<br />
[Custom offer]<br />
Please contact us at:<br />
customresearch@cerep.com<br />
Source<br />
Ligand<br />
Kd<br />
Non specific<br />
Reference<br />
CTLL-2 cells<br />
[ 125 I]IL-2 (0.02 nM)<br />
0.02 nM<br />
IL-2 (50 nM)<br />
IL-2 (IC 50 : 0.06 nM)<br />
Robb, R.J. et al. (1984) J. Exp. Med., 160: 1126-1146.<br />
specific b<strong>in</strong>d<strong>in</strong>g (% of control)<br />
100<br />
50<br />
0<br />
-13 -12 -11 -10 -9 -8<br />
log [drug] (M)<br />
IL-2<br />
IL-1β<br />
IL-4<br />
IL-6<br />
IL-4 - agonist radioligand<br />
b<strong>in</strong>d<strong>in</strong>g<br />
Ref. 0074<br />
[Custom offer]<br />
Please contact us at:<br />
customresearch@cerep.com<br />
Source<br />
Ligand<br />
Kd<br />
Non specific<br />
Reference<br />
MLA 144 cells<br />
[ 125 I]IL-4 (0.03 nM)<br />
0.03 nM<br />
IL-4 (100 nM)<br />
IL-4 (IC 50 : 0.1 nM)<br />
Galizzi, J.P. et al. (1990) J. Biol. Chem., 265: 439-444.<br />
specific b<strong>in</strong>d<strong>in</strong>g (% of control)<br />
100<br />
50<br />
0<br />
-12 -11 -10 -9 -8<br />
log [drug] (M)<br />
IL-4<br />
IL-1α<br />
IL-6 - agonist radioligand<br />
b<strong>in</strong>d<strong>in</strong>g<br />
Ref. 0075<br />
[Custom offer]<br />
Please contact us at:<br />
customresearch@cerep.com<br />
Source<br />
Ligand<br />
Kd<br />
Non specific<br />
Reference<br />
U-266 cells<br />
[ 125 I]IL-6 (0.05 nM)<br />
0.25 nM<br />
IL-6 (20 nM)<br />
IL-6 (IC 50 : 0.3 nM)<br />
Taga, T. et al. (1987) J. Exp. Med., 166: 967-981.<br />
specific b<strong>in</strong>d<strong>in</strong>g (% of control)<br />
100<br />
50<br />
0<br />
-11 -10 -9 -8 -7<br />
log [drug] (M)<br />
IL-6<br />
IL-1α<br />
IL-4<br />
IL-2<br />
❚ GABA<br />
GABA (non-selective) - agonist radioligand<br />
b<strong>in</strong>d<strong>in</strong>g<br />
Ref. 0057<br />
Q 3 weeks<br />
Included <strong>in</strong>:<br />
ExpresS Profile<br />
High-throughput profile<br />
Diversity profile<br />
Source<br />
Ligand<br />
Kd<br />
Non specific<br />
Reference<br />
rat cerebral cortex<br />
[ 3 H]GABA (10 nM)<br />
15 nM<br />
GABA (100 µM)<br />
GABA (IC 50 : 25 nM)<br />
Tsuji, A. et al. (1988) Antimicrob. Agents Chemother., 32: 190-194.<br />
specific b<strong>in</strong>d<strong>in</strong>g (% of control)<br />
100<br />
50<br />
0<br />
-10 -9 -8 -7 -6 -5 -4 -3<br />
log [drug] (M)<br />
GABA<br />
muscimol<br />
baclofen<br />
For further details and updated <strong>in</strong>formation on assays:<br />
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