in vitro PHARMACOLOGY 2011 CATALOG - Cerep
in vitro PHARMACOLOGY 2011 CATALOG - Cerep
in vitro PHARMACOLOGY 2011 CATALOG - Cerep
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150 <strong>in</strong> <strong>vitro</strong> pharmacology <strong>2011</strong> catalog<br />
❚ prote<strong>in</strong>-SERINE/THREONINE k<strong>in</strong>ases [TKL]<br />
IRAK4<br />
Ref. 2933<br />
Q 3 weeks<br />
Included <strong>in</strong>:<br />
ExpresS Diversity k<strong>in</strong>ase profile<br />
Organ safety profile<br />
Comprehensive k<strong>in</strong>ase profile<br />
Source<br />
human recomb<strong>in</strong>ant (<strong>in</strong>sect cells)<br />
Substrate ATP + Ulight-FLGFTYVAP<br />
(50 nM)<br />
Measured product phospho-Ulight-FLGFTYVAP<br />
Detection method LANCE<br />
Reference staurospor<strong>in</strong>e (IC 50 : 32 nM)<br />
Li, S. et al. (2002) Proc. Natl. Acad. Sci. U S A., 99: 5567-5572.<br />
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LIMK1<br />
Ref. 2934<br />
Q 3 weeks<br />
Included <strong>in</strong>:<br />
Comprehensive k<strong>in</strong>ase profile<br />
Source<br />
human recomb<strong>in</strong>ant (Sf21 cells)<br />
Substrate ATP + Ulight-RRRSLLE<br />
(50 nM)<br />
Measured product phospho-Ulight-RRRSLLE<br />
Detection method LANCE<br />
Reference<br />
staurospor<strong>in</strong>e (IC 50 : 59 nM)<br />
Scott, R.W. and Olson, M.F. (2007) J. Mol. Med., 85: 555-568.<br />
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LRRK2<br />
Ref. 3177<br />
Q 3 weeks<br />
Source<br />
human recomb<strong>in</strong>ant (<strong>in</strong>sect cells)<br />
Substrate ATP + Ulight-RRRSLLE<br />
(50 nM)<br />
Measured product phospho-Ulight-RRRSLLE<br />
Detection method LANCE<br />
Reference<br />
H-89 (IC 50 : 30 nM)<br />
Greggio, E. et al. (2008) J. Biol. Chem., 283: 16906-16914.<br />
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MLK1<br />
Ref. 2935<br />
Q 3 weeks<br />
Included <strong>in</strong>:<br />
Comprehensive k<strong>in</strong>ase profile<br />
Source<br />
human recomb<strong>in</strong>ant<br />
Substrate ATP + Ulight-FLGFTYVAP<br />
(400 nM)<br />
Measured product phospho-Ulight-FLGFTYVAP<br />
Detection method LANCE<br />
Reference<br />
staurospor<strong>in</strong>e (IC 50 : 21.5 nM)<br />
Maroney, A.C. et al. (2001) Biochem. J., 276: 25302-25308.<br />
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MLK2 (MAP3K10)<br />
Ref. 2326<br />
Q 3 weeks<br />
Included <strong>in</strong>:<br />
Comprehensive k<strong>in</strong>ase profile<br />
Source<br />
human recomb<strong>in</strong>ant (<strong>in</strong>sect cells)<br />
Substrate ATP + Ulight-ARTKQTARKSTGGKAPRKQLAGCG<br />
(25 nM)<br />
Measured product phospho-Ulight-ARTKQTARKSTGGKAPRKQL<br />
AGCG<br />
Detection method LANCE<br />
Reference<br />
staurospor<strong>in</strong>e (IC 50 : 79 nM)<br />
Liu, Y.F. et al. (2000) J. Biol. Chem., 275: 19035-19040.<br />
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RAF-1 k<strong>in</strong>ase<br />
Ref. 2936<br />
Q 3 weeks<br />
Included <strong>in</strong>:<br />
ExpresS Diversity k<strong>in</strong>ase profile<br />
Organ safety profile<br />
Comprehensive k<strong>in</strong>ase profile<br />
Source<br />
human recomb<strong>in</strong>ant<br />
Substrate ATP + Ulight-ARTKQTARKSTGGKAPRKQLAGCG<br />
(50 nM)<br />
Measured product phospho-Ulight-ARTKQTARKSTGGKAPRKQL<br />
AGCG<br />
Detection method LANCE<br />
Reference staurospor<strong>in</strong>e (IC 50 : 94 nM)<br />
Force, T. et al. (1994) Proc. Natl. Acad. Sci. USA., 91: 1270-1274.
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