in vitro PHARMACOLOGY 2011 CATALOG - Cerep
in vitro PHARMACOLOGY 2011 CATALOG - Cerep
in vitro PHARMACOLOGY 2011 CATALOG - Cerep
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187<br />
ion transport systems ❚<br />
Na + /H + antiport<br />
<br />
cellul ar<br />
Ref. 0223<br />
[CUSTOM OFFER]<br />
Source<br />
A7r5 cells<br />
Tracer<br />
22 Na (0.4 µCi)<br />
Measured product<br />
22 Na uptake<br />
Detection method sc<strong>in</strong>tillation count<strong>in</strong>g<br />
Reference<br />
EIPA (IC 50 : 50 nM)<br />
Jean, T. et al. (1986) Eur. J. Biochem., 160: 211-219.<br />
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<strong>Cerep</strong><br />
services<br />
Receptors<br />
Na + /K + /Cl – cotransport<br />
100<br />
cellul ar<br />
Ref. 0224<br />
[CUSTOM OFFER]<br />
Source<br />
Tracer<br />
Measured product<br />
Detection method<br />
Reference<br />
A7r5 cells<br />
86 Rb (0.2 µCi)<br />
86 Rb uptake<br />
sc<strong>in</strong>tillation count<strong>in</strong>g<br />
bumetanide (IC 50 : 1 µM)<br />
Chassande, O. et al. (1988) Eur. J. Biochem., 171: 425-433.<br />
86 Rb uptake (% of control)<br />
50<br />
0<br />
-8 -7 -6 -5 -4<br />
log [drug] (M)<br />
bumetanide<br />
furosemide<br />
Ion<br />
channels<br />
Transporters<br />
❚ Arachidonic acid metabolite secretion<br />
K<strong>in</strong>ases<br />
LTB 4 secretion (<strong>in</strong>hibitor effect)<br />
cellul ar<br />
Ref. 0243<br />
[CUSTOM OFFER]<br />
Source<br />
differentiated HL-60 cells<br />
Stimulant<br />
A23187 (5 µM)<br />
Measured product LTB 4<br />
Detection method EIA<br />
Reference<br />
[Solvent] must be kept ≤ 0.3%<br />
NDGA (IC 50 : 470 nM)<br />
Bennett, C.F. et al. (1993) Biochem. J., 289: 33-39.<br />
LTB 4 secretion (% of control)<br />
100<br />
50<br />
0<br />
-8 -7 -6 -5 -4<br />
log [drug] (M)<br />
NDGA<br />
zileuton<br />
phenidone<br />
ETYA<br />
Epigenetic &<br />
DNA-related<br />
enzymes<br />
Other<br />
enzymes<br />
LTC 4 secretion (<strong>in</strong>hibitor effect)<br />
cellul ar<br />
Ref. 0395<br />
[CUSTOM OFFER]<br />
Source<br />
differentiated HL-60 cells<br />
Stimulant<br />
A23187 (5 µM)<br />
Measured product LTC 4<br />
Detection method<br />
Reference<br />
EIA<br />
PMA (IC 50 : 5 nM)<br />
Bennett, C.F. et al. (1993) Biochem. J., 289: 33-39.<br />
LTC 4 secretion (% of control)<br />
100<br />
50<br />
0<br />
PMA<br />
NDGA<br />
-10 -9 -8 -7 -6 -5<br />
log [drug] (M)<br />
<br />
Specialized<br />
cellular<br />
assays<br />
Standard<br />
profiles<br />
PGE 2 secretion (<strong>in</strong>hibitor effect)<br />
cellul ar<br />
Ref. 0238<br />
[CUSTOM OFFER]<br />
Source<br />
differentiated HL-60 cells<br />
Stimulant<br />
A23187 (5 µM)<br />
Measured product PGE 2<br />
Detection method EIA<br />
Reference<br />
<strong>in</strong>domethac<strong>in</strong> (IC 50 : 4 nM)<br />
[Solvent] must be kept ≤ 0.3%<br />
Honda, A. et al. (1990) Biochem. J., 272: 259-262.<br />
PGE2 secretion (% of control)<br />
100<br />
50<br />
0<br />
-11 -10 -9 -8 -7 -6 -5 -4 -3<br />
log [drug] (M)<br />
<strong>in</strong>domethac<strong>in</strong><br />
diclofenac<br />
ibuprofen<br />
acetylsalicylic<br />
acid<br />
Test<strong>in</strong>g<br />
conditions<br />
Order<strong>in</strong>g<br />
<strong>in</strong>formation<br />
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Assay list<br />
& <strong>in</strong>dex
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