in vitro PHARMACOLOGY 2011 CATALOG - Cerep
in vitro PHARMACOLOGY 2011 CATALOG - Cerep
in vitro PHARMACOLOGY 2011 CATALOG - Cerep
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124 <strong>in</strong> <strong>vitro</strong> pharmacology <strong>2011</strong> catalog<br />
❚ Prote<strong>in</strong>-SERINE/THREONINE k<strong>in</strong>ases [CMGC]<br />
CDC2/CDK1 (cycB)<br />
Ref. 2875<br />
Q 3 weeks<br />
Included <strong>in</strong>:<br />
ExpresS Diversity k<strong>in</strong>ase profile<br />
Organ safety profile<br />
Comprehensive k<strong>in</strong>ase profile<br />
Source<br />
human recomb<strong>in</strong>ant (<strong>in</strong>sect cells)<br />
Substrate<br />
ATP + Ulight-CFFKNIVTPRTPPPSQGK-amide<br />
(100 nM)<br />
Measured product phospho-Ulight-CFFKNIVTPRTPPPSQGKamide<br />
Detection method LANCE<br />
Reference<br />
staurospor<strong>in</strong>e (IC 50 : 8 nM)<br />
Meijer, L. et al. (1997) Eur. J. Biochem., 243: 527-536.<br />
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CDK2 (cycA)<br />
Ref. 2908<br />
Q 3 weeks<br />
Included <strong>in</strong>:<br />
ExpresS Diversity k<strong>in</strong>ase profile<br />
BioPr<strong>in</strong>t ® profile<br />
Comprehensive k<strong>in</strong>ase profile<br />
Source<br />
human recomb<strong>in</strong>ant<br />
Substrate<br />
ATP + Ulight-CFFKNIVTPRTPPPSQGK-amide<br />
(50 nM)<br />
Measured product phospho-Ulight-CFFKNIVTPRTPPPSQGKamide<br />
Detection method LANCE<br />
Reference<br />
staurospor<strong>in</strong>e (IC 50 : 7.1 nM)<br />
Meijer, L. et al. (1997) Eur. J. Biochem., 243: 527-536.<br />
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CDK3 (cycE1)<br />
Ref. 2679<br />
Q 3 weeks<br />
Included <strong>in</strong>:<br />
Comprehensive k<strong>in</strong>ase profile<br />
Source<br />
human recomb<strong>in</strong>ant<br />
Substrate<br />
ATP + Ulight-CFFKNIVTPRTPPPSQGK-amide<br />
(100 nM)<br />
Measured product phospho-Ulight-CFFKNIVTPRTPPPSQGKamide<br />
Detection method LANCE<br />
Reference<br />
Ro-318220 (IC 50 : 10.8 nM)<br />
Braun, K. et al. (1998) Oncogene, 17: 2259-2269.<br />
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CDK4 (cycD1)<br />
Ref. 2876<br />
Q 3 weeks<br />
Included <strong>in</strong>:<br />
Comprehensive k<strong>in</strong>ase profile<br />
Source<br />
human recomb<strong>in</strong>ant (Sf9 cells)<br />
Substrate<br />
ATP + Ulight-CFFKNIVTPRTPPPSQGK-amide<br />
(100 nM)<br />
Measured product phospho-Ulight-CFFKNIVTPRTPPPSQGKamide<br />
Detection method LANCE<br />
Reference<br />
staurospor<strong>in</strong>e (IC 50 : 181 nM)<br />
Kim, D.M. et al. (2003) Exp. Mol. Med., 35: 421-430.<br />
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CDK5/p35<br />
Ref. 2877<br />
Q 3 weeks<br />
Included <strong>in</strong>:<br />
Organ safety profile<br />
Comprehensive k<strong>in</strong>ase profile<br />
Source<br />
human recomb<strong>in</strong>ant (<strong>in</strong>sect cells)<br />
Substrate<br />
ATP + Ulight-CFFKNIVTPRTPPPSQGK-amide<br />
(100 nM)<br />
Measured product phospho-Ulight-CFFKNIVTPRTPPPSQGKamide<br />
Detection method LANCE<br />
Reference<br />
staurospor<strong>in</strong>e (IC 50 : 13.5 nM)<br />
Meijer, L. et al. (1997) Eur. J. Biochem., 243: 527-536.<br />
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For further details and updated <strong>in</strong>formation on assays:<br />
❚ Please go to www.cerep.com catalog onl<strong>in</strong>e or contact us at sales@cerep.com<br />
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❚ Europe: +33 (0)5 49 89 30 00 – USA: +1 (425) 895 8666 – Japan: +81 (0)3 3354 4026 – Ch<strong>in</strong>a: +86 21 5132 0568<br />
Assay developed <strong>in</strong> 2010 New assay conditions and/or assay converted from HTRF ® to LANCEUltra ®<br />
<br />
Human Q Standard turnaround time
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