in vitro PHARMACOLOGY 2011 CATALOG - Cerep
in vitro PHARMACOLOGY 2011 CATALOG - Cerep
in vitro PHARMACOLOGY 2011 CATALOG - Cerep
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160 <strong>in</strong> <strong>vitro</strong> pharmacology <strong>2011</strong> catalog<br />
❚ hdacs<br />
HDAC9<br />
Source<br />
Substrate<br />
Measured product<br />
Detection method<br />
human recomb<strong>in</strong>ant<br />
fluorogenic HDAC substrate class 2a<br />
(50 µM)<br />
fluoro-lys<strong>in</strong>e<br />
fluorimetry<br />
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α<br />
Ref. 2611<br />
Q 3 weeks<br />
Reference<br />
trichostat<strong>in</strong> A (IC 50 : 3 µM)<br />
Strahl, B.D. and Allis, C.D. (2000) Nature, 403: 41-45.<br />
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<br />
HDAC10<br />
Ref. 2662<br />
Q 3 weeks<br />
Source<br />
human recomb<strong>in</strong>ant<br />
Substrate<br />
fluorogenic HDAC substrate (20 µM)<br />
Measured product fluoro-lys<strong>in</strong>e<br />
Detection method fluorimetry<br />
Reference<br />
trichostat<strong>in</strong> A (IC 50 : 13 nM)<br />
Strahl, B.D. and Allis, C.D. (2000) Nature, 403: 41-45.<br />
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α<br />
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HDAC11<br />
Ref. 2663<br />
Q 3 weeks<br />
Included <strong>in</strong>:<br />
Non-k<strong>in</strong>ase enzyme profile<br />
Diversity profile<br />
Organ safety profile<br />
Source<br />
human recomb<strong>in</strong>ant<br />
Substrate<br />
fluorogenic HDAC substrate class 2a<br />
(20 µM)<br />
Measured product fluoro-lys<strong>in</strong>e<br />
Detection method fluorimetry<br />
Reference<br />
scriptaid (IC 50 : 94 µM)<br />
Strahl, B.D. and Allis, C.D. (2000) Nature, 403: 41-45.<br />
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α<br />
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<br />
sirtu<strong>in</strong> 1 (activator effect)<br />
Source<br />
human recomb<strong>in</strong>ant (E. coli)<br />
Substrate<br />
fluorogenic HDAC substrate (200 µM)<br />
Measured product fluoro-lys<strong>in</strong>e<br />
Detection method fluorimetry<br />
Reference<br />
resveratrol (EC 50 : 50 µM)<br />
Ref. 2991<br />
Q 3 weeks<br />
Michan, S. and S<strong>in</strong>clair, D. (2007) Biochem. J., 404: 1-13.<br />
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sirtu<strong>in</strong> 1(<strong>in</strong>hibitor effect)<br />
Ref. 2581<br />
Q 3 weeks<br />
Included <strong>in</strong>:<br />
Non-k<strong>in</strong>ase enzyme profile<br />
Diversity profile<br />
Organ safety profile<br />
Source<br />
Substrate<br />
Measured product<br />
Detection method<br />
Reference<br />
human recomb<strong>in</strong>ant (E. coli)<br />
fluorogenic HDAC substrate (200 µM)<br />
fluoro-lys<strong>in</strong>e<br />
fluorimetry<br />
suram<strong>in</strong> (IC 50 : 4.5 µM)<br />
Michan, S. and S<strong>in</strong>clair, D. (2007) Biochem. J., 404: 1-13.<br />
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sirtu<strong>in</strong> 2<br />
Ref. 2582<br />
Q 3 weeks<br />
Included <strong>in</strong>:<br />
Non-k<strong>in</strong>ase enzyme profile<br />
Diversity profile<br />
Organ safety profile<br />
Source<br />
human recomb<strong>in</strong>ant (E. coli)<br />
Substrate<br />
fluoro-lys<strong>in</strong>e sirtu<strong>in</strong> 2 deacetylase substrate<br />
(150 µM)<br />
Measured product fluoro-lys<strong>in</strong>e<br />
Detection method fluorimetry<br />
Reference<br />
suram<strong>in</strong> (IC 50 : 26 µM)<br />
Michan, S. and S<strong>in</strong>clair, D. (2007) Biochem. J., 404: 1-13.
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