in vitro PHARMACOLOGY 2011 CATALOG - Cerep
in vitro PHARMACOLOGY 2011 CATALOG - Cerep
in vitro PHARMACOLOGY 2011 CATALOG - Cerep
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122 <strong>in</strong> <strong>vitro</strong> pharmacology <strong>2011</strong> catalog<br />
❚ prote<strong>in</strong>-tyros<strong>in</strong>e k<strong>in</strong>ases [Ctk]<br />
PYK2<br />
Ref. 3077<br />
Q 3 weeks<br />
Included <strong>in</strong>:<br />
Organ safety profile<br />
Comprehensive k<strong>in</strong>ase profile<br />
Source<br />
Substrate<br />
Measured product<br />
Detection method<br />
Reference<br />
human recomb<strong>in</strong>ant<br />
ATP + Ulight-TK peptide<br />
(100 nM)<br />
phospho-Ulight-TK peptide<br />
LANCE<br />
staurospor<strong>in</strong>e (IC 50 : 5.1 nM)<br />
Benbernou, N. et al. (2000) J. Biol. Chem., 275: 7060-7065.<br />
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Src k<strong>in</strong>ase<br />
Ref. 2907<br />
Q 3 weeks<br />
Included <strong>in</strong>:<br />
ExpresS Diversity k<strong>in</strong>ase profile<br />
Organ safety profile<br />
Comprehensive k<strong>in</strong>ase profile<br />
Source<br />
human recomb<strong>in</strong>ant (<strong>in</strong>sect cells)<br />
Substrate<br />
ATP + Ulight-Poly GAT[EAY(1:1:1)]n<br />
(5 nM)<br />
Measured product phospho-Ulight-Poly GAT[EAY(1:1:1)]n<br />
Detection method LANCE<br />
Reference<br />
staurospor<strong>in</strong>e (IC 50 : 9 nM)<br />
Cheng, H.C. et al. (1992) J. Biol. Chem., 267: 9248-9256.<br />
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Srm k<strong>in</strong>ase<br />
Ref. 2646<br />
Q 3 weeks<br />
Source<br />
human recomb<strong>in</strong>ant<br />
Substrate<br />
ATP + Ulight-Poly GAT[EAY(1:1:1)]n<br />
(5 nM)<br />
Measured product phospho-Ulight-Poly GAT[EAY(1:1:1)]n<br />
Detection method LANCE<br />
Reference<br />
staurospor<strong>in</strong>e (IC 50 : 625 nM)<br />
Kohmura, N. et al. (1994) Mol. Cell. Biol., 14: 6915-6925.<br />
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Syk<br />
Ref. 2780<br />
Q 3 weeks<br />
Included <strong>in</strong>:<br />
Organ safety profile<br />
Comprehensive k<strong>in</strong>ase profile<br />
Source<br />
human recomb<strong>in</strong>ant<br />
Substrate<br />
ATP + Ulight-CAGAGAIETDKEYYTVKD<br />
(150 nM)<br />
Measured product phospho-Ulight-CAGAGAIETDKEYYTVKD<br />
Detection method LANCE<br />
Reference<br />
staurospor<strong>in</strong>e (IC 50 : 2.1 nM)<br />
Yamamoto, N. et al. (2003) Anal. Biochem., 315: 256-261.<br />
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TEC k<strong>in</strong>ase<br />
Ref. 3076<br />
Q 3 weeks<br />
Source<br />
human recomb<strong>in</strong>ant<br />
Substrate<br />
ATP + Ulight-TK peptide<br />
(100 nM)<br />
Measured product phospho-Ulight-TK peptide<br />
Detection method LANCE<br />
Reference<br />
staurospor<strong>in</strong>e (IC 50 : 64 nM)<br />
Lachance, G. et al. (2002) J. Biol. Chem., 277: 21537-21541.<br />
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Tnk1<br />
Ref. 2785<br />
Q 3 weeks<br />
Included <strong>in</strong>:<br />
Comprehensive k<strong>in</strong>ase profile<br />
Source<br />
human recomb<strong>in</strong>ant<br />
Substrate<br />
ATP + Ulight-Poly GAT[EAY(1:1:1)]n<br />
(5 nM)<br />
Measured product phospho-Ulight-Poly GAT[EAY(1:1:1)]n<br />
Detection method LANCE<br />
Reference<br />
staurospor<strong>in</strong>e (IC 50 : 2.1 nM)<br />
Hoehn, G.T. et al. (1996) Oncogene, 12: 903-913.
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