in vitro PHARMACOLOGY 2011 CATALOG - Cerep
in vitro PHARMACOLOGY 2011 CATALOG - Cerep
in vitro PHARMACOLOGY 2011 CATALOG - Cerep
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165<br />
phosphatases ❚<br />
phosphatase LAR (PTPRF)<br />
Source<br />
Substrate<br />
Measured product<br />
Detection method<br />
human recomb<strong>in</strong>ant (E. coli)<br />
DIFMUP (150 µM)<br />
DIFMU<br />
fluorimetry<br />
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<strong>Cerep</strong><br />
services<br />
Ref. 2803<br />
Q 3 weeks<br />
Reference<br />
ammonium molybdate (IC 50 : 300 nM)<br />
Welte, S. et al. (2005) Anal. biochem., 338: 32-38.<br />
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Receptors<br />
phosphatase MEG1 (PTPN4)<br />
Source<br />
human recomb<strong>in</strong>ant (E. coli)<br />
Substrate<br />
DIFMUP (30 µM)<br />
Measured product DIFMU<br />
Detection method fluorimetry<br />
Ref. 2807<br />
Reference<br />
ammonium molybdate (IC 50 : 800 nM)<br />
Q 3 weeks<br />
Welte, S. et al. (2005) Anal. biochem., 338: 32-38.<br />
phosphatase MEG2 (PTPN9)<br />
Source<br />
human recomb<strong>in</strong>ant (E. coli)<br />
Substrate<br />
DIFMUP (150 µM)<br />
Measured product DIFMU<br />
Detection method fluorimetry<br />
Ref. 2808<br />
Reference<br />
ammonium molybdate (IC 50 : 310 nM)<br />
Q 3 weeks<br />
Welte, S. et al. (2005) Anal. biochem., 338: 32-38.<br />
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Ion<br />
channels<br />
Transporters<br />
K<strong>in</strong>ases<br />
Epigenetic &<br />
DNA-related<br />
enzymes<br />
phosphatase MKP1<br />
Ref. 2652<br />
Q 3 weeks<br />
Source<br />
human recomb<strong>in</strong>ant<br />
Substrate<br />
DIFMUP (100 µM)<br />
Measured product DIFMU<br />
Detection method fluorimetry<br />
Reference<br />
NSC 663284 (IC 50 : 8.2 µM)<br />
Lazo, J.S. et al. (2007) J. Pharmacol. Exp. Ther., 322: 940-947.<br />
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Other<br />
enzymes<br />
Specialized<br />
cellular<br />
assays<br />
phosphatase MKP2<br />
Ref. 2653<br />
Q 3 weeks<br />
Source<br />
human recomb<strong>in</strong>ant<br />
Substrate<br />
DIFMUP (100 µM)<br />
Measured product DIFMU<br />
Detection method fluorimetry<br />
Reference<br />
NSC 663284 (IC 50 : 35.5 µM)<br />
Chen, P. et al. (2001) J. Biol. Chem., 27: 29440-29449.<br />
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Standard<br />
profiles<br />
Test<strong>in</strong>g<br />
conditions<br />
phosphatase MKP3<br />
Ref. 2654<br />
Q 3 weeks<br />
Source<br />
human recomb<strong>in</strong>ant<br />
Substrate<br />
DIFMUP (100 µM)<br />
Measured product DIFMU<br />
Detection method fluorimetry<br />
Reference<br />
NSC 663284 (IC 50 : 5.2 µM)<br />
Fjeld, C.C. et al. (2000) J. Biol. Chem., 275: 6749-6757.<br />
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Order<strong>in</strong>g<br />
<strong>in</strong>formation<br />
Assay list<br />
& <strong>in</strong>dex
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