Research Profile - College of Medicine and Health Science - United ...

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Department of Pathology among United Arab Emirates nationals and their correlation with the expression P53,Ki 67,bcl2,nm2, c-erb-B2, estrogen receptors and progesterone receptors. 3. Role of Trefoil Factor Peptides in the Development and Progression of Glioma. Gliomas are the most common primary central nervous system tumors. They are the second most common cancer among children in UAE. They are graded into four grades from grade 1 which is the most benign to grade 4 which is the most malignant. They are characterized by progression from low grade to high grade within the same tumor. This progression is not well understood. Furthermore, the pathogenesis of glioma is obscure. Several studies have shown the transforming potential of TFF peptides which is illustrated in tissues involved in cancer progression, while other studies have shown tumor suppressor action of TFF peptides. How can the apparent contradiction between the tumor-promoting and tumor-suppressing functions of TFF peptides be resolved We hope that this project will answer some of these queries. There is nearly no published data concerning the expression of TFFs in human gliomas. In addition there were no previous reports concerning the role of trefoil factors in the pathogenesis or progression of glioma. Our preliminary study on few cases of gliomas using immunohistochemical stains have shown expression of TFF 3 in gliomas with difference in the expression between low grade and high grade gliomas. 4. Role of Galectin 1, 3, 4, 7 and 10 in the development and progression of uterine cervical carcinoma Uterine cervical cancer is the second most common cancer in women worldwide, and the fifth most common cancer among females in UAE. Although high-risk human papillomaviruses (HPVs) are associated with cervical carcinoma, HPV infection alone is insufficient for the malignant transformation. Hence other molecular alterations are required for the development of cervical carcinoma and galectins may play an important role in these processes. The main purpose of this proposal is to study the expression of galectin-1, 3, 4, 7 and 10 in the neoplastic cells of different types, grades and stages of human uterine cervical carcinomas. We expect that our suggested studies will clarify and elucidate the role of galectin 1, 3, 4, 7 and 10 in the pathogenesis and progression of human uterine cervical carcinoma. In this project, we will verify this hypothesis by extending our experiments on peritumoral stromal mononuclear cells as well as non-neoplastic and dysplastic uterine cervical tissues. 5. Expression of estrogen receptors alpha and beta and progesterone receptors in thyroid carcinoma among UAE Nationals Thyroid carcinoma (TC) is the sixth most common cancer among the United Arab Emirates (UAE) nationals and the second among UAE national females. The striking gender differences in the incidence of differentiated thyroid cancer, particularly for papillary thyroid carcinoma (PTC), suggests a possible influence of hormone related factors because the higher overall incidence of female PTC is established through a sharp increase during the fertile years of life. We found a high preponderance of differentiated thyroid carcinoma among UAE female nationals during the child – bearing age, which was much higher than expatriates and other studies else where. We think that this finding suggests a possible hormonal influence and needs to be thoroughly investigated. We will review the cases of thyroid carcinoma which were diagnosed in the Pathology Department at Tawam Hospital for the period 1988 through 2007 for histological classification and demographic data. All cases diagnosed as thyroid carcinoma will be examined for the expression of estrogen receptors alpha and beta, progesterone receptors, EGFR, c-erb-B2, c- kit, cyclin D1, bcl- xL and p53 using immunohistochemistry (IHC) as well as fluorescent in situ hybridization (FISH) for EGFR, c-erb-B2 and cyclin D1 to determine the frequency of expression of estrogen and progesterone receptors in relation to the expression of EGFR, c-erb-B2, c-kit, cyclin D1, bclxL and p53 in different types of thyroid carcinoma among UAE nationals and in comparison with their expression among expatriates. This study will enable us to understand the role of sex steroid hormones and various growth factors in the development of thyroid carcinoma among UAE nationals. 57
Department of Pathology The Genetic and Molecular Basis of Diseases prevalent in UAE (Dr. Bassam R. Ali) Current Research Focus: 1. Identification of the molecular defects underlying single gene disorders in UAE and Arab populations. Recessive disorders are highly prevalent in Arab populations including UAE mainly due to high levels of consanguinity and lack of prenatal and/or pre-conception diagnosis. We are developing a molecular genetics research laboratory to look at the molecular defects causing recessive disorders found in the UAE population with emphasis on mental retardation phenotypes, metabolic and dysmorphology disorders. We are collaborating with major research groups at Harvard Medical School, University of California in San Diego and Cambridge University. 2. The cellular mechanisms of human monogenic disorders. We are interested in protein trafficking and quality control within eukaryotic cells. The protein quality control at the endoplasmic reticulum level is responsible for the development of several human genetic diseases including cystic fibrosis and emphysema. We recently elucidated the cellular mechanisms underlying Robinow syndrome and Acromesomelic Dysplasia type Maroteaux, recessive disorders that have been found in several parts of the Middle East including Oman and Saudi Arabia. We are currently looking to establish the mechanisms underlying Familial Hypercholesterolemia, Hereditary Hemorrhagic Telangiectasia and other ER-associated degradation diseases. In addition, we are exploring ways of manipulation of ER quality control for potential therapy of such diseases. 3. Pharmacogenetics. With Dr. S. Bastaki and Prof.Y. Abdulrazzaq, we started establishing the alleles for CYP2D6 gene and other drug metabolizing enzymes prevalent in UAE population. Departmental Undertaking: Drs Alia Al Bawardi and Saeeda Al Marzooqi (resident trainees) are completing their training in Pathology at McGill University, Montreal, Canada. Articles in Peerreviewed Journals Agarwal MM, Dhatt GS, Safraou MF. (2008). Gestational diabetes: using a portable glucometer to simplify the approach to screening. Gynecologic and Obstetric Investigation, 66:178-183. Al-Dhaheri WS, Hassouna I, Al- Salam S, Karam SM. (2008). Characterization of breast cancer progression in the rat. Ann N Y Acad Sci, 1138:121-31. Al-Ramadi BK, Fernandez- Cabezudo MJ, El-Hasasna H, Al- Salam S, Attoub S, Xu D, Chouaib S. (2008). Attenuated bacteria as effectors in cancer immunotherapy. Ann N Y Acad Sci, 1138:351-7. Al-Salam S, Alashari M. (2008). Expression of Galectin-3, CD138, P16 INK4a and TTF-1 in Mucinous Bronchioloalveolar adenocarcinoma following Hodgkin's lymphoma. Applied Immunohistochemistry & Molecular Morphology. [ePub 2008] Al-Salam S, John A, Daoud S, Chong SM, Castella A. (2008). Expression of Epstein-Barr virus in Hodgkin lymphoma in a population of United Arab Emirates nationals. Leuk Lymphoma, 49(9):1769-77. Al-Salam S, Algawi K, Alashari M. (2008). Malignant Non- Teratoid Medulloepithelioma of ciliary body with Retinoblastic differentiation - A case report and review of literature. Neuropathology, 28(5):551-6. Al-Salam S, Nowotny N, Sohail M R, Kolodziejek J, Berger T G. (2008). Ecthyma contagiosum (orf) – report of a human case from the United Arab Emirates and review of the literature. Cutan Pathol, 35(6):603-7. Al-Salam S, Al Ashari M, Ghazal- Aswad S. (2008). Expression of 58
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2008 Research Publications & Resear
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Table of Contents Preface I Dean’
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Dean’s Message It is my pleasure
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Department of Anatomy Research Prof
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Department of Anatomy Jerry Buzzell
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Department of Anatomy Books, Chapte
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