Chromosome segregation errors: a double-edged sword - TI Pharma
Chromosome segregation errors: a double-edged sword - TI Pharma
Chromosome segregation errors: a double-edged sword - TI Pharma
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Chapter 6<br />
Aneuploid tumor cells are more sensitive to<br />
inhibitors of the mitotic checkpoint kinase Mps1<br />
Aniek Janssen 1,2 , Husam Alwan 2 , Björn ter Horst 2 , Ute Boon 3 , Rita Maia 1 , Joost C.M. Uitdehaag 4 , Jos<br />
de Man 4 , Geert J.P.L. Kops 2,5 , Rogier C. Buijsman 4 , Jos Jonkers 3 , Guido J.R. Zaman 4 , René H. Medema 1,2<br />
1 Division of Cell Biology, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, the<br />
Netherlands<br />
2 Department of Medical Oncology and Cancer Genomics Center, University Medical Center Utrecht,<br />
Universiteitsweg 100, 3584 CG, Utrecht, the Netherlands<br />
3 Division of Molecular Cell Biology, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX,<br />
Amsterdam, the Netherlands<br />
4 Netherlands Translational Research Center B.V., P.O. Box 20, 5340 AG, Oss, the Netherlands<br />
5 Department of Molecular Cancer Research, University Medical Center Utrecht, Universiteitsweg 100,<br />
3584 CG, Utrecht, the Netherlands<br />
Manuscript in preparation<br />
115<br />
Mps1 inhibition kills aneuploid cells<br />
6