Chromosome segregation errors: a double-edged sword - TI Pharma

559. Kienitz, A., et al., Partial downregulation of MAD1 causes spindle checkpoint inactivation and aneuploidy, but does
not confer resistance towards taxol. Oncogene, 2005. 24(26): p. 4301-10.
560. Lee, E.A., et al., Inactivation of the mitotic checkpoint as a determinant of the efficacy of microtubule-targeted drugs
in killing human cancer cells. Mol Cancer Ther, 2004. 3(6): p. 661-9.
561. DeBonis, S., et al., In vitro screening for inhibitors of the human mitotic kinesin Eg5 with antimitotic and antitumor
activities. Mol Cancer Ther, 2004. 3(9): p. 1079-90.
562. Mayr, M.I., et al., The human kinesin Kif18A is a motile microtubule depolymerase essential for chromosome
congression. Curr Biol, 2007. 17(6): p. 488-98.
563. Schmidt, M., et al., Ablation of the spindle assembly checkpoint by a compound targeting Mps1. EMBO Rep, 2005.
6(9): p. 866-72.
564. Draviam, V.M., et al., A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling.
Nat Cell Biol, 2007. 9(5): p. 556-64.
565. Meraldi, P. and P.K. Sorger, A dual role for Bub1 in the spindle checkpoint and chromosome congression. EMBO J,
2005. 24(8): p. 1621-33.
566. Lens, S.M., et al., Survivin is required for a sustained spindle checkpoint arrest in response to lack of tension. EMBO J,
2003. 22(12): p. 2934-47.
567. Tanenbaum, M.E., et al., Dynein, Lis1 and CLIP-170 counteract Eg5-dependent centrosome separation during bipolar
spindle assembly. EMBO J, 2008. 27(24): p. 3235-45.
568. Brown, K.D., K.W. Wood, and D.W. Cleveland, The kinesin-like protein CENP-E is kinetochore-associated throughout
poleward chromosome segregation during anaphase-A. J Cell Sci, 1996. 109 ( Pt 5): p. 961-9.
569. Hansemann, D.P.v., Über asymmetrische Zelltheilung in Epithelkrebsen und deren biologische Bedeutung. Archiv für
pathologische Anatomie and Physiologie und für klinische Medicin, 1890. 779: p. 299-326.
570. Suijkerbuijk, S.J. and G.J. Kops, Preventing aneuploidy: the contribution of mitotic checkpoint proteins. Biochim
Biophys Acta, 2008. 1786(1): p. 24-31.
571. Jones, M.H., et al., Chemical genetics reveals a role for Mps1 kinase in kinetochore attachment during mitosis. Curr
Biol, 2005. 15(2): p. 160-5.
572. van der Waal, M.S., et al., Cell division control by the Chromosomal Passenger Complex. Exp Cell Res, 2012.
573. Janssen, A., G.J. Kops, and R.H. Medema, Targeting the mitotic checkpoint to kill tumor cells. Horm Cancer, 2011.
2(2): p. 113-6.
574. Lan, W. and D.W. Cleveland, A chemical tool box defines mitotic and interphase roles for Mps1 kinase. J Cell Biol,
2010. 190(1): p. 21-4.
575. Amabile, G., et al., The Aurora B kinase activity is required for the maintenance of the differentiated state of murine
myoblasts. Cell Death Differ, 2009. 16(2): p. 321-30.
576. Chu, M.L., et al., Biophysical and X-ray crystallographic analysis of Mps1 kinase inhibitor complexes. Biochemistry,
2010. 49(8): p. 1689-701.
577. Miduturu, C.V., et al., High-throughput kinase profiling: a more efficient approach toward the discovery of new kinase
inhibitors. Chem Biol, 2011. 18(7): p. 868-79.
578. Tardif, K.D., et al., Characterization of the cellular and antitumor effects of MPI-0479605, a small-molecule inhibitor of
the mitotic kinase Mps1. Mol Cancer Ther, 2011. 10(12): p. 2267-75.
579. Caldarelli, M., et al., pyrazolo-quinazolines. patent WO 2009/156315 A1, Nerviano Medical Sciences (Nerviano, Italy)
2009
580. Uitdehaag, J.C. and G.J. Zaman, A theoretical entropy score as a single value to express inhibitor selectivity. BMC
Bioinformatics, 2011. 12: p. 94.
581. Clute, P. and J. Pines, Temporal and spatial control of cyclin B1 destruction in metaphase. Nat Cell Biol, 1999. 1(2): p.
82-7.
582. Hagting, A., et al., Human securin proteolysis is controlled by the spindle checkpoint and reveals when the APC/C
switches from activation by Cdc20 to Cdh1. J Cell Biol, 2002. 157(7): p. 1125-37.
583. Hahn, W.C. and R.A. Weinberg, Rules for making human tumor cells. N Engl J Med, 2002. 347(20): p. 1593-603.
584. Dyson, N., et al., Cellular proteins that are targetted by DNA tumor viruses for transformation. Princess Takamatsu
Symp, 1989. 20: p. 191-8.
585. Caldarelli, M., et al., Synthesis and SAR of new pyrazolo[4,3-h]quinazoline-3-carboxamide derivatives as potent and
selective MPS1 kinase inhibitors. Bioorg Med Chem Lett, 2011. 21(15): p. 4507-11.
586. Rottenberg, S., M. Pajic, and J. Jonkers, Studying drug resistance using genetically engineered mouse models for
breast cancer. Methods Mol Biol, 2010. 596: p. 33-45.
587. Uitdehaag, J.C., et al., A guide to picking the most selective kinase inhibitor tool compounds for pharmacological
validation of drug targets. Br J Pharmacol, 2012. 166(3): p. 858-876.
588. Huson, D.H., et al., Dendroscope: An interactive viewer for large phylogenetic trees. BMC Bioinformatics, 2007. 8: p.
460.
589. Bissery, M.C., et al., Docetaxel (Taxotere): a review of preclinical and clinical experience. Part I: Preclinical experience.
Anticancer Drugs, 1995. 6(3): p. 339-55, 363-8.
590. Noguchi, S., Predictive factors for response to docetaxel in human breast cancers. Cancer Sci, 2006. 97(9): p. 813-20.
591. Davies, A.M., et al., Docetaxel in non-small cell lung cancer: a review. Expert Opin Pharmacother, 2003. 4(4): p. 553-
65.
592. Nogales, E., et al., Structure of tubulin at 6.5 A and location of the taxol-binding site. Nature, 1995. 375(6530): p. 424-
7.
593. Schiff, P.B., J. Fant, and S.B. Horwitz, Promotion of microtubule assembly in vitro by taxol. Nature, 1979. 277(5698): p.
665-7.
594. Schiff, P.B. and S.B. Horwitz, Taxol stabilizes microtubules in mouse fibroblast cells. Proc Natl Acad Sci U S A, 1980.
77(3): p. 1561-5.
595. Ringel, I. and S.B. Horwitz, Studies with RP 56976 (taxotere): a semisynthetic analogue of taxol. J Natl Cancer Inst,
1991. 83(4): p. 288-91.
596. Yvon, A.M., P. Wadsworth, and M.A. Jordan, Taxol suppresses dynamics of individual microtubules in living human
tumor cells. Mol Biol Cell, 1999. 10(4): p. 947-59.
597. Orth, J.D., et al., Analysis of mitosis and antimitotic drug responses in tumors by in vivo microscopy and single-cell
pharmacodynamics. Cancer Res, 2011. 71(13): p. 4608-16.
598. Milas, L., et al., Kinetics of mitotic arrest and apoptosis in murine mammary and ovarian tumors treated with taxol.
Cancer Chemother Pharmacol, 1995. 35(4): p. 297-303.
599. Milross, C.G., et al., Relationship of mitotic arrest and apoptosis to antitumor effect of paclitaxel. J Natl Cancer Inst,
1996. 88(18): p. 1308-14.
600. Symmans, W.F., et al., Paclitaxel-induced apoptosis and mitotic arrest assessed by serial fine-needle aspiration:
implications for early prediction of breast cancer response to neoadjuvant treatment. Clin Cancer Res, 2000. 6(12): p.
173
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