Chromosome segregation errors: a double-edged sword - TI Pharma

470. Marcus, A.I., et al., Mitotic kinesin inhibitors induce mitotic arrest and cell death in Taxol-resistant and -sensitive
cancer cells. J Biol Chem, 2005. 280(12): p. 11569-77.
471. Huszar, D., et al., Kinesin motor proteins as targets for cancer therapy. Cancer Metastasis Rev, 2009. 28(1-2): p. 197-
208.
472. Brier, S., et al., Molecular dissection of the inhibitor binding pocket of mitotic kinesin Eg5 reveals mutants that confer
resistance to antimitotic agents. J Mol Biol, 2006. 360(2): p. 360-76.
473. Tcherniuk, S., et al., Mutations in the human kinesin Eg5 that confer resistance to monastrol and S-trityl-L-cysteine in
tumor derived cell lines. Biochem Pharmacol, 2010. 79(6): p. 864-72.
474. Maliga, Z. and T.J. Mitchison, Small-molecule and mutational analysis of allosteric Eg5 inhibition by monastrol. BMC
Chem Biol, 2006. 6: p. 2.
475. Tanenbaum, M.E., et al., Kif15 cooperates with eg5 to promote bipolar spindle assembly. Curr Biol, 2009. 19(20): p.
1703-11.
476. Vanneste, D., et al., The role of Hklp2 in the stabilization and maintenance of spindle bipolarity. Curr Biol, 2009.
19(20): p. 1712-7.
477. Lok, W., R.Q. Klein, and M.W. Saif, Aurora kinase inhibitors as anti-cancer therapy. Anticancer Drugs, 2010. 21(4): p.
339-50.
478. Strebhardt, K. and A. Ullrich, Targeting polo-like kinase 1 for cancer therapy. Nat Rev Cancer, 2006. 6(4): p. 321-30.
479. Carmena, M. and W.C. Earnshaw, The cellular geography of aurora kinases. Nat Rev Mol Cell Biol, 2003. 4(11): p. 842-
54.
480. Barr, F.A., H.H. Sillje, and E.A. Nigg, Polo-like kinases and the orchestration of cell division. Nat Rev Mol Cell Biol, 2004.
5(6): p. 429-40.
481. Yao, X., et al., CENP-E forms a link between attachment of spindle microtubules to kinetochores and the mitotic
checkpoint. Nat Cell Biol, 2000. 2(8): p. 484-91.
482. Wood, K.W., et al., Antitumor activity of an allosteric inhibitor of centromere-associated protein-E. Proc Natl Acad Sci
U S A, 2010. 107(13): p. 5839-44.
483. Schafer-Hales, K., et al., Farnesyl transferase inhibitors impair chromosomal maintenance in cell lines and human
tumors by compromising CENP-E and CENP-F function. Mol Cancer Ther, 2007. 6(4): p. 1317-28.
484. Rieder, C.L. and H. Maiato, Stuck in division or passing through: what happens when cells cannot satisfy the spindle
assembly checkpoint. Dev Cell, 2004. 7(5): p. 637-51.
485. Brito, D.A. and C.L. Rieder, Mitotic checkpoint slippage in humans occurs via cyclin B destruction in the presence of an
active checkpoint. Curr Biol, 2006. 16(12): p. 1194-200.
486. Shi, J., J.D. Orth, and T. Mitchison, Cell type variation in responses to antimitotic drugs that target microtubules and
kinesin-5. Cancer Res, 2008. 68(9): p. 3269-76.
487. Brito, D.A. and C.L. Rieder, The ability to survive mitosis in the presence of microtubule poisons differs significantly
between human nontransformed (RPE-1) and cancer (U2OS, HeLa) cells. Cell Motil Cytoskeleton, 2009. 66(8): p. 437-
47.
488. Stobbe, C.C., S.J. Park, and J.D. Chapman, The radiation hypersensitivity of cells at mitosis. Int J Radiat Biol, 2002.
78(12): p. 1149-57.
489. Westra, A. and W.C. Dewey, Variation in sensitivity to heat shock during the cell-cycle of Chinese hamster cells in vitro.
Int J Radiat Biol Relat Stud Phys Chem Med, 1971. 19(5): p. 467-77.
490. Uetake, Y. and G. Sluder, Prolonged prometaphase blocks daughter cell proliferation despite normal completion of
mitosis. Curr Biol, 2010. 20(18): p. 1666-71.
491. Allan, L.A. and P.R. Clarke, Phosphorylation of caspase-9 by CDK1/cyclin B1 protects mitotic cells against apoptosis.
Mol Cell, 2007. 26(2): p. 301-10.
492. Harley, M.E., et al., Phosphorylation of Mcl-1 by CDK1-cyclin B1 initiates its Cdc20-dependent destruction during
mitotic arrest. EMBO J, 2010. 29(14): p. 2407-20.
493. Terrano, D.T., M. Upreti, and T.C. Chambers, Cyclin-dependent kinase 1-mediated Bcl-xL/Bcl-2 phosphorylation acts as
a functional link coupling mitotic arrest and apoptosis. Mol Cell Biol, 2010. 30(3): p. 640-56.
494. Vantieghem, A., et al., Phosphorylation of Bcl-2 in G2/M phase-arrested cells following photodynamic therapy with
hypericin involves a CDK1-mediated signal and delays the onset of apoptosis. J Biol Chem, 2002. 277(40): p. 37718-
31.
495. Wu, L., et al., Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and
subsequent functional suppression. J Biol Chem, 2010.
496. Ando, K., et al., Polo-like kinase 1 (Plk1) inhibits p53 function by physical interaction and phosphorylation. J Biol
Chem, 2004. 279(24): p. 25549-61.
497. Ha, G.H., et al., p53 activation in response to mitotic spindle damage requires signaling via BubR1-mediated
phosphorylation. Cancer Res, 2007. 67(15): p. 7155-64.
498. Huang, H.C., et al., Evidence that mitotic exit is a better cancer therapeutic target than spindle assembly. Cancer Cell,
2009. 16(4): p. 347-58.
499. Manchado, E., et al., Targeting mitotic exit leads to tumor regression in vivo: Modulation by Cdk1, Mastl, and the
PP2A/B55alpha,delta phosphatase. Cancer Cell, 2010. 18(6): p. 641-54.
500. Rieder, C.L. and R.H. Medema, No way out for tumor cells. Cancer Cell, 2009. 16(4): p. 274-5.
501. Zeng, X., et al., Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent
mitotic arrest in the absence of spindle damage. Cancer Cell, 2010. 18(4): p. 382-95.
502. Barr, F.A. and U. Gruneberg, Cytokinesis: placing and making the final cut. Cell, 2007. 131(5): p. 847-60.
503. Kaitna, S., et al., Incenp and an aurora-like kinase form a complex essential for chromosome segregation and efficient
completion of cytokinesis. Curr Biol, 2000. 10(19): p. 1172-81.
504. Harrington, E.A., et al., VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses
tumor growth in vivo. Nat Med, 2004. 10(3): p. 262-7.
505. Kaestner, P., A. Stolz, and H. Bastians, Determinants for the efficiency of anticancer drugs targeting either Aurora-A or
Aurora-B kinases in human colon carcinoma cells. Mol Cancer Ther, 2009. 8(7): p. 2046-56.
506. Keen, N. and S. Taylor, Mitotic drivers--inhibitors of the Aurora B Kinase. Cancer Metastasis Rev, 2009. 28(1-2): p. 185-
95.
507. Wilkinson, R.W., et al., AZD1152, a selective inhibitor of Aurora B kinase, inhibits human tumor xenograft growth by
inducing apoptosis. Clin Cancer Res, 2007. 13(12): p. 3682-8.
508. Oke, A., et al., AZD1152 rapidly and negatively affects the growth and survival of human acute myeloid leukemia cells
in vitro and in vivo. Cancer Res, 2009. 69(10): p. 4150-8.
509. Uetake, Y. and G. Sluder, Cell cycle progression after cleavage failure: mammalian somatic cells do not possess a
“tetraploidy checkpoint”. J Cell Biol, 2004. 165(5): p. 609-15.
510. Wong, C. and T. Stearns, Mammalian cells lack checkpoints for tetraploidy, aberrant centrosome number, and
cytokinesis failure. BMC Cell Biol, 2005. 6(1): p. 6.
171
Addendum
&