Chromosome segregation errors: a double-edged sword - TI Pharma

&
426. Giunta, S., R. Belotserkovskaya, and S.P. Jackson, DNA damage signaling in response to double-strand breaks during
mitosis. J Cell Biol, 2010. 190(2): p. 197-207.
427. van Vugt, M.A., et al., A mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to
inactivate the G(2)/M DNA damage checkpoint. PLoS Biol, 2010. 8(1): p. e1000287.
428. Petrini, J.H. and T.H. Stracker, The cellular response to DNA double-strand breaks: defining the sensors and mediators.
Trends Cell Biol, 2003. 13(9): p. 458-62.
429. Matsuoka, S., et al., Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro. Proc Natl Acad Sci U S A,
2000. 97(19): p. 10389-94.
430. Hickson, I., et al., Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia
mutated kinase ATM. Cancer Res, 2004. 64(24): p. 9152-9.
431. Thompson, S.L. and D.A. Compton, Proliferation of aneuploid human cells is limited by a p53-dependent mechanism. J
Cell Biol, 2010. 188(3): p. 369-81.
432. Smith, G.C. and S.P. Jackson, The DNA-dependent protein kinase. Genes Dev, 1999. 13(8): p. 916-34.
433. Szuhai, K. and H.J. Tanke, COBRA: combined binary ratio labeling of nucleic-acid probes for multi-color fluorescence in
situ hybridization karyotyping. Nat Protoc, 2006. 1(1): p. 264-75.
434. Kapoor, T.M., et al., Probing spindle assembly mechanisms with monastrol, a small molecule inhibitor of the mitotic
kinesin, Eg5. J Cell Biol, 2000. 150(5): p. 975-88.
435. Vassilev, L.T., Cell cycle synchronization at the G2/M phase border by reversible inhibition of CDK1. Cell Cycle, 2006.
5(22): p. 2555-6.
436. Vassilev, L.T., et al., Selective small-molecule inhibitor reveals critical mitotic functions of human CDK1. Proc Natl Acad
Sci U S A, 2006. 103(28): p. 10660-5.
437. Saunders, W.S., et al., Chromosomal instability and cytoskeletal defects in oral cancer cells. Proc Natl Acad Sci U S A,
2000. 97(1): p. 303-8.
438. Miyoshi, Y., et al., Acceleration of chromosomal instability by loss of BRCA1 expression and p53 abnormality in
sporadic breast cancers. Cancer Lett, 2000. 159(2): p. 211-6.
439. Beheshti, B., et al., Evidence of chromosomal instability in prostate cancer determined by spectral karyotyping (SKY)
and interphase fish analysis. Neoplasia, 2001. 3(1): p. 62-9.
440. Kops, G.J., The kinetochore and spindle checkpoint in mammals. Front Biosci, 2008. 13: p. 3606-20.
441. Musacchio, A. and E.D. Salmon, The spindle-assembly checkpoint in space and time. Nat Rev Mol Cell Biol, 2007. 8(5):
p. 379-93.
442. Lampson, M.A. and T.M. Kapoor, The human mitotic checkpoint protein BubR1 regulates chromosome-spindle
attachments. Nat Cell Biol, 2005. 7(1): p. 93-8.
443. Johnson, V.L., et al., Bub1 is required for kinetochore localization of BubR1, Cenp-E, Cenp-F and Mad2, and
chromosome congression. J Cell Sci, 2004. 117(Pt 8): p. 1577-89.
444. Ganem, N.J., Z. Storchova, and D. Pellman, Tetraploidy, aneuploidy and cancer. Curr Opin Genet Dev, 2007. 17(2): p.
157-62.
445. Williams, B.R., et al., Aneuploidy affects proliferation and spontaneous immortalization in mammalian cells. Science,
2008. 322(5902): p. 703-9.
446. Torres, E.M., et al., Effects of aneuploidy on cellular physiology and cell division in haploid yeast. Science, 2007.
317(5840): p. 916-24.
447. Janssen, A. and R.H. Medema, Mitosis as an anti-cancer target. Oncogene, 2011. 30(25): p. 2799-809.
448. Dankort, D., et al., A new mouse model to explore the initiation, progression, and therapy of BRAFV600E-induced lung
tumors. Genes Dev, 2007. 21(4): p. 379-84.
449. Ventura, A., et al., Restoration of p53 function leads to tumour regression in vivo. Nature, 2007. 445(7128): p. 661-5.
450. Indra, A.K., et al., Temporally-controlled site-specific mutagenesis in the basal layer of the epidermis: comparison of
the recombinase activity of the tamoxifen-inducible Cre-ER(T) and Cre-ER(T2) recombinases. Nucleic Acids Res, 1999.
27(22): p. 4324-7.
451. Soriano, P., Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat Genet, 1999. 21(1): p. 70-1.
452. Reiners, J.J., Jr., S. Nesnow, and T.J. Slaga, Murine susceptibility to two-stage skin carcinogenesis is influenced by the
agent used for promotion. Carcinogenesis, 1984. 5(3): p. 301-7.
453. Vasioukhin, V., et al., The magical touch: genome targeting in epidermal stem cells induced by tamoxifen application
to mouse skin. Proc Natl Acad Sci U S A, 1999. 96(15): p. 8551-6.
454. Muller, W.J., et al., Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu
oncogene. Cell, 1988. 54(1): p. 105-15.
455. van der Weyden, L., et al., Null and conditional semaphorin 3B alleles using a flexible puroDeltatk loxP/FRT vector.
Genesis, 2005. 41(4): p. 171-8.
456. Truett, G.E., et al., Preparation of PCR-quality mouse genomic DNA with hot sodium hydroxide and tris (HotSHOT).
Biotechniques, 2000. 29(1): p. 52, 54.
457. Jordan, M.A. and L. Wilson, Microtubules as a target for anticancer drugs. Nat Rev Cancer, 2004. 4(4): p. 253-65.
458. Manfredi, J.J. and S.B. Horwitz, Taxol: an antimitotic agent with a new mechanism of action. Pharmacol Ther, 1984.
25(1): p. 83-125.
459. Jordan, M.A., D. Thrower, and L. Wilson, Mechanism of inhibition of cell proliferation by Vinca alkaloids. Cancer Res,
1991. 51(8): p. 2212-22.
460. Jordan, M.A., et al., Mechanism of mitotic block and inhibition of cell proliferation by taxol at low concentrations.
Proc Natl Acad Sci U S A, 1993. 90(20): p. 9552-6.
461. Rowinsky, E.K., et al., Microtubule changes and cytotoxicity in leukemic cell lines treated with taxol. Cancer Res, 1988.
48(14): p. 4093-100.
462. Goodin, S., Novel cytotoxic agents: epothilones. Am J Health Syst Pharm, 2008. 65(10 Suppl 3): p. S10-5.
463. Yue, Q.X., X. Liu, and D.A. Guo, Microtubule-binding natural products for cancer therapy. Planta Med, 2010. 76(11): p.
1037-43.
464. Rowinsky, E.K., et al., Clinical toxicities encountered with paclitaxel (Taxol). Semin Oncol, 1993. 20(4 Suppl 3): p. 1-15.
465. Tuxen, M.K. and S.W. Hansen, Neurotoxicity secondary to antineoplastic drugs. Cancer Treat Rev, 1994. 20(2): p. 191-
214.
466. Harrison, M.R., K.D. Holen, and G. Liu, Beyond taxanes: a review of novel agents that target mitotic tubulin and
microtubules, kinases, and kinesins. Clin Adv Hematol Oncol, 2009. 7(1): p. 54-64.
467. Sawin, K.E., et al., Mitotic spindle organization by a plus-end-directed microtubule motor. Nature, 1992. 359(6395): p.
540-3.
468. Blangy, A., et al., Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor
essential for bipolar spindle formation in vivo. Cell, 1995. 83(7): p. 1159-69.
469. Mayer, T.U., et al., Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen.
Science, 1999. 286(5441): p. 971-4.
170