Chromosome segregation errors: a double-edged sword - TI Pharma

&
4610-7.
601. Beerling, E., et al., Intravital microscopy: new insights into metastasis of tumors. J Cell Sci, 2011. 124(Pt 3): p. 299-
310.
602. Porter, A.G. and R.U. Janicke, Emerging roles of caspase-3 in apoptosis. Cell Death Differ, 1999. 6(2): p. 99-104.
603. Bins, A.D., et al., Intravital imaging of fluorescent markers and FRET probes by DNA tattooing. BMC Biotechnol, 2007.
7: p. 2.
604. Keese, M., et al., Quantitative imaging of apoptosis commitment in colorectal tumor cells. Differentiation, 2007.
75(9): p. 809-18.
605. Keese, M., et al., Fluorescence lifetime imaging microscopy of chemotherapy-induced apoptosis resistance in a
syngenic mouse tumor model. Int J Cancer, 2010. 126(1): p. 104-13.
606. van der Wal, J., et al., Monitoring agonist-induced phospholipase C activation in live cells by fluorescence resonance
energy transfer. J Biol Chem, 2001. 276(18): p. 15337-44.
607. Gurskaya, N.G., et al., Engineering of a monomeric green-to-red photoactivatable fluorescent protein induced by blue
light. Nat Biotechnol, 2006. 24(4): p. 461-5.
608. Kedrin, D., et al., Intravital imaging of metastatic behavior through a mammary imaging window. Nat Methods,
2008. 5(12): p. 1019-21.
609. Gligorijevic, B., et al., Dendra2 photoswitching through the Mammary Imaging Window. J Vis Exp, 2009(28).
610. van Munster, E.B. and T.W. Gadella, Fluorescence lifetime imaging microscopy (FLIM). Adv Biochem Eng Biotechnol,
2005. 95: p. 143-75.
611. Ritsma, L., B. Ponsioen, and J. van Rheenen, Intravital imaging of cell signaling in mice. Intravital, 2012. 1(1).
612. Mitchison, T.J., The proliferation rate paradox in antimitotic chemotherapy. Mol Biol Cell, 2012. 23(1): p. 1-6.
613. Nakasone, E.S., et al., Imaging tumor-stroma interactions during chemotherapy reveals contributions of the
microenvironment to resistance. Cancer Cell, 2012. 21(4): p. 488-503.
614. Javeed, A., et al., Paclitaxel and immune system. Eur J Pharm Sci, 2009. 38(4): p. 283-90.
615. Fitzpatrick, F.A. and R. Wheeler, The immunopharmacology of paclitaxel (Taxol), docetaxel (Taxotere), and related
agents. Int Immunopharmacol, 2003. 3(13-14): p. 1699-714.
616. Tang, Y.C., et al., Identification of aneuploidy-selective antiproliferation compounds. Cell, 2011. 144(4): p. 499-512.
617. Duesberg, P., et al., Genetic instability of cancer cells is proportional to their degree of aneuploidy. Proc Natl Acad Sci
U S A, 1998. 95(23): p. 13692-7.
618. Burds, A.A., A.S. Lutum, and P.K. Sorger, Generating chromosome instability through the simultaneous deletion of
Mad2 and p53. Proc Natl Acad Sci U S A, 2005. 102(32): p. 11296-301.
619. Cimini, D., C. Tanzarella, and F. Degrassi, Differences in malsegregation rates obtained by scoring ana-telophases or
binucleate cells. Mutagenesis, 1999. 14(6): p. 563-8.
620. Harrigan, J.A., et al., Replication stress induces 53BP1-containing OPT domains in G1 cells. J Cell Biol, 2011. 193(1): p.
97-108.
621. Lukas, C., et al., 53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes
under replication stress. Nat Cell Biol, 2011. 13(3): p. 243-53.
622. Guerrero, A.A., et al., Centromere-localized breaks indicate the generation of DNA damage by the mitotic spindle.
Proc Natl Acad Sci U S A, 2009. 107(9): p. 4159-64.
623. Stephens, P.J., et al., Massive genomic rearrangement acquired in a single catastrophic event during cancer
development. Cell, 2011. 144(1): p. 27-40.
624. Maher, C.A. and R.K. Wilson, Chromothripsis and human disease: piecing together the shattering process. Cell, 2012.
148(1-2): p. 29-32.
625. Kloosterman, W.P., et al., Chromothripsis as a mechanism driving complex de novo structural rearrangements in the
germline. Hum Mol Genet, 2011. 20(10): p. 1916-24.
626. Rausch, T., et al., Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with
TP53 mutations. Cell, 2012. 148(1-2): p. 59-71.
627. Kloosterman, W.P., Constitutional Chromothripsis Rearrangements Involve Clustered Double-Stranded DNA Breaks
and Nonhomologous Repair Mechanisms. Cell Reports, 2012(doi:10.1016/j.celrep.2012.05.009).
628. Carlton, J.G., et al., ESCRT-III governs the Aurora B-mediated abscission checkpoint through CHMP4C. Science, 2012.
336(6078): p. 220-5.
629. Rajagopalan, H. and C. Lengauer, Aneuploidy and cancer. Nature, 2004. 432(7015): p. 338-41.
630. Pei, L. and S. Melmed, Isolation and characterization of a pituitary tumor-transforming gene (PTTG). Mol Endocrinol,
1997. 11(4): p. 433-41.
631. Zhang, D., et al., Cre-loxP-controlled periodic Aurora-A overexpression induces mitotic abnormalities and hyperplasia
in mammary glands of mouse models. Oncogene, 2004. 23(54): p. 8720-30.
632. Pavelka, N., et al., Aneuploidy confers quantitative proteome changes and phenotypic variation in budding yeast.
Nature, 2010. 468(7321): p. 321-5.
633. Rancati, G., et al., Aneuploidy underlies rapid adaptive evolution of yeast cells deprived of a conserved cytokinesis
motor. Cell, 2008. 135(5): p. 879-93.
634. Cavenee, W.K., et al., Expression of recessive alleles by chromosomal mechanisms in retinoblastoma. Nature, 1983.
305(5937): p. 779-84.
635. Duesberg, P., A. Fabarius, and R. Hehlmann, Aneuploidy, the primary cause of the multilateral genomic instability of
neoplastic and preneoplastic cells. IUBMB Life, 2004. 56(2): p. 65-81.
636. Zomer, A., et al., Real-time intravital imaging of cancer models. Clin Transl Oncol, 2011. 13(12): p. 848-54.
637. McGranahan, N., et al., Cancer chromosomal instability: therapeutic and diagnostic challenges. EMBO Rep, 2012.
13(6): p. 528-38.
638. Hudis, C.A., Trastuzumab--mechanism of action and use in clinical practice. N Engl J Med, 2007. 357(1): p. 39-51.
639. Michel, L., R. Benezra, and E. Diaz-Rodriguez, MAD2 dependent mitotic checkpoint defects in tumorigenesis and
tumor cell death: a double edged sword. Cell Cycle, 2004. 3(8): p. 990-2.
174