Vitamin D and Health
SACN_Vitamin_D_and_Health_report
SACN_Vitamin_D_and_Health_report
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Study/year/country Population Rickets diagnosis Mean 25(OH)D (nmol/L) & Ca (mg/L)<br />
concentrations<br />
Ca intake/other<br />
comments<br />
Brouwers et al (2010)<br />
Netherl<strong>and</strong>s<br />
2 brothers. South Asian ethnic origin, living in<br />
Netherl<strong>and</strong>s (2 years)<br />
Patient 1 - age 12 y; presented with waddling<br />
gait, muscular weakness <strong>and</strong> bone pain<br />
Patient 2 -age 14y; presented with waddling<br />
gait <strong>and</strong> pain when climbing stairs<br />
Biochemical, clinical & radiographic<br />
evidence.<br />
Case 1<br />
25(OH)D: 8/Ca: 76<br />
Case 2<br />
25(OH)D: 4/Ca: not reported<br />
Case 1: 100 mg/d<br />
Case 2: 330 mg/d<br />
Akin et al (2010)<br />
Kayseri, Turkey<br />
Male aged 23 m. Presented with recurrent<br />
febrile convulsions.<br />
Diagnosed as antiepileptic drug-induced<br />
<strong>Vitamin</strong> D deficiency rickets.<br />
Mild enlargement of wrists bilaterally but<br />
rachitic rosary, craniotabes, caput<br />
quadratum, & leg deformities not present.<br />
25(OH)D: 4.5/Ca: 64<br />
Ca intakes not<br />
reported.<br />
Pearson et al (2010)<br />
California, USA<br />
Male aged 16 m. Presented with weight loss,<br />
elevated alkaline phosphatase <strong>and</strong> PTH.<br />
Hispanic ethnicity.<br />
Clinical features of rickets - bow legs &<br />
mild frontal bossing.<br />
Radiographs consistent with early signs of<br />
rickets: widening & irregular metaphyses of<br />
distal femur & proximal tibia.<br />
25(OH)D: 4.5/Ca: 89<br />
Ca intakes not<br />
reported.<br />
Brinsmead et al (2011)<br />
Brisbane, Australia<br />
Girl aged 12 m<br />
Ethnicity, Indian; born Australia.<br />
Radiological appearance of wrist <strong>and</strong> knees<br />
consistent with rickets; tender <strong>and</strong><br />
widened wrists; hypocalcaemia.<br />
25(OH)D: 11.2/Ca: 69<br />
Ca intakes not<br />
reported.<br />
Zurlo & Wagner (2012)<br />
Livingstone, US<br />
Male, aged 8 m. African American. Presented<br />
at Emergency Dept. with fever.<br />
X-rays showed flaring of ribs at<br />
costochondral junction (rachitic rosary),<br />
fraying & cupping of distal radial & ulnar<br />
metaphyses plus biochemical evidence.<br />
25(OH)D: below threshold for detection.<br />
Ca: concentration not reported<br />
Ca intakes not<br />
reported.<br />
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