Vitamin D and Health

Table 32: Intervention studies on effect of vitamin D supplementation during pregnancy on maternal non-skeletal reproductive health outcomes
Study/Country Population/Design of study Design Intervention/Duration
Mean 25(0H)D
maternal baseline
(nmol/L)
Mean 25(OH)D
cord (nmol/L)
Results/Comments
Hollis et al (2011)
S Carolina
US
Pregnant women 12-16 weeks
gestation (n=350)
RCT
1. 10µg/d
2. 50µg/d
3. 100µg/d
From 12-16 wks until delivery
79 (±86)
98 (±34)
111 (±40)
45 (±25)
57 (±25)
66 (±26)
No significant effect of
vitamin D on risk of
instrumental delivery;
however, no control group.
Table 33: Intervention studies on effect of vitamin D supplementation during pregnancy on neonatal hypocalcaemia
Study/Country Population/Design of study Design Intervention/Duration
Mean 25(0H)D
maternal baseline
(nmol/L)
Mean 25(OH)D
cord (nmol/L)
Results/Comments
Cockburn et al
(1980)
Edinburgh
Scotland
Pregnant women (n=1139) Non-RCT 1. 10µg/d D2
2. Placebo
From 12 wks of pregnancy to delivery
24 weeks
1. 39
2. 32.5
34 weeks
1. 44.5
2. 38.5
Delivery
1. 42.8
2. 32.5
1. 28
2. 20
Neonatal hypocalcaemia
(defined as plasma
Ca 2+ < 1.85 mmol/L) occurred
in 6% of the intervention
group infants and 13% of
controls (p < 0.005).
Brooke et al (1981)
London
UK
South Asian women in their
last trimester (n=126)
RCT
1. 25 µg/day
2. Placebo
Throughout last trimester of
pregnancy
1. 168
2. 16
1. 138
(SE=10.8)
2. 10 (SE=2.0)
5 infants in control gp but 0 n
treatment gp developed
hypocalcaemia (plasma Ca2+
< 1.8 nmol/L). 25(OH)D
concentrations in cord &
maternal plasma greatly
exceed those observed in
other studies.
Delvin et al (1986)
Lyon
France
Pregnant women at the end of
1 st trimester (n=40)
RCT
1. 25 µg/d D3
2. No treatment
Throughout last trimester.
1. 45 (5)
2. 17.5 (2.5)
1. 32.5 (2.5)
2. 12.5 (2.5)
(serum
concentration 4
days after
birth)
Significant difference
(p