Vitamin D and Health
SACN_Vitamin_D_and_Health_report
SACN_Vitamin_D_and_Health_report
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Infants (0-12m)<br />
Table 10: RCTs on effect of vitamin D supplementation on bone health indices in infants<br />
Study/Country Population Intervention & study<br />
duration<br />
Mean 25(OH)D conc (nmol/L) Bone health results Comments<br />
Kim et al (2010)<br />
Cheongiu, Korea<br />
New born breast<br />
fed infants (n=74)<br />
3 groups<br />
1. Formula<br />
2. 10 µg/d*<br />
3. No intervention<br />
12 months<br />
At birth: 44.2 (17.4)<br />
After 12 m:<br />
1. 121.8 (24.3)<br />
2. 106.8 (24.5)<br />
3. 82.9 919.7)<br />
BMD significantly higher in formula fed<br />
group than vit D intervention & no<br />
intervention groups.<br />
BMC significantly higher in in formula fed<br />
group than vit D group but no differences<br />
between formula-fed group <strong>and</strong> no<br />
intervention group or between vit D group<br />
<strong>and</strong> no intervention group.<br />
Poor study design.<br />
Number of core<br />
uncertainties.<br />
Kumar et al (2011)<br />
New Delhi, India<br />
Low birth-weight<br />
newborn infants<br />
aged 7 days<br />
(n=2079)<br />
35µg/wk or placebo.<br />
6 months<br />
At baseline:<br />
Not reported.<br />
After 6 m:<br />
<strong>Vitamin</strong> D: 55 (22.5)<br />
Control: 36 (25.5)<br />
Vit D supplementation increased SD z scores<br />
at 6m for weight, length <strong>and</strong> arm<br />
circumference <strong>and</strong> significantly decreased<br />
head circumference.<br />
Number of participants less<br />
than highlighted in abstract<br />
(n=216, vit D group; n=237,<br />
placebo group).<br />
Abrams et al (2012)<br />
Houston, USA<br />
Infants aged 1 wk<br />
(n=49)<br />
10 µg/d<br />
3 months<br />
At baseline:<br />
Non-Hispanic: 55.7 (23.5)<br />
Hispanic: 40.9 (16.2)<br />
After 3m<br />
White - 57.4 (23.5))<br />
Hispanic: 42.2 (18)<br />
No relationship between cord serum<br />
25(OH)D <strong>and</strong> BMC or BMD during 1 st week of<br />
life or after 3 months of vitamin D<br />
supplementation.<br />
Small study.<br />
Limited time allowed to<br />
show effect on bone indices.<br />
Holmlund-Suila et al<br />
(2012)<br />
Finl<strong>and</strong><br />
Infants aged 2 wks<br />
(n=113)<br />
1. 10 µg/d<br />
2. 30 µg/d<br />
3. 40 µg/d<br />
10 weeks<br />
1. 88<br />
2. 124<br />
3. 153<br />
No difference in PTH or bone turnover<br />
markers.<br />
Using peripheral quantitative computed<br />
tomography in a multivariate ANCOVA there<br />
was a trend toward better stress <strong>and</strong> strain<br />
index <strong>and</strong> larger total bone <strong>and</strong> cortical bone<br />
area was noted with higher vitamin D doses.<br />
10 weeks short treatment<br />
time to show change in<br />
bone architecture <strong>and</strong><br />
mineral accrual.<br />
*Supplement also contained contains vitamin A (1,500 IU/mL), vitamin E (5 IU/mL), vitamin C (35 mg/mL), thiamin (0.5 mg/mL), riboflavin (0.6 mg/mL), niacin (8 mg/mL), vitamin B6 (0.4mg/mL), iron (10 mg/mL), <strong>and</strong> fluoride<br />
(0.25 mg/mL).<br />
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