Vitamin D and Health

Table 45: Prospective studies on serum 25(OH)D concentration and all-cause mortality risk
Study Population Mean follow up Mean 25(OH)D (nmol/L) Results/ comments
Formiga et al
(2014)
Spain
Wong et al (2013)
Australia
Sempos et al
(2013)
US
Community dwelling older
adults (n=328)
Age: >85 y
Participants from the Health
in Men Study (HIMS)
(n=4203)
Mean age 76 y (70-88)
Participants in NHANES III
study (n=15,099)
Age: 45 years
median
2.8 y ()
70/L (±75)
Q1: 84
6.7 y 68.3 (±23.3)
Q1 10-52.8
Q2 52.9-67.3
Q3 67.4-81.6
Q4 81.7-238.4
Q1: OR = 1.28 (95% CI, 0.61-2.6); p=0.41
Q2: OR = 1.36 (95% CI, 0.67-2.74)
Q3: OR = 0.76 (95% CI, 0.34-1.68)
Q4: OR 1.00 (reference)
25(OH)D not associated with overall mortality in older community dwelling
adults.
Per 10 nmol/L decrease in 25(OH)D: OR = 1.04 (95% CI, 1.01-1.07)
Halving of 25(OH)D: OR = 1.21 (95% CI, 1.08-1.35)
By quartile:
Q1: OR = 1.20 (95% CI, 1.02-1.42)
Q2: OR = 1.0 (ref)
Q3: OR = 0.99 (95% CI, 0.84-1.17)
Q4: OR = 0.99 (95% CI, 0.83, 1.17)
15 y 64 (±0.73)