Vitamin D and Health

Study/country Population Rickets diagnosis Treatment Mean 25(OH)D (nmol/L) & Ca
(mg/L) concentrations
Ozkan et al (2009)
Turkey
Children diagnosed as VDDR
(n=21).
Age: 2-24 m (median age at
referral, 7.3 (2-16) m).
Clinical evidence, 2 or more of following:
craniotabes (in infants > 2m), bilateral
widened wrists, frontal bossing, bowing of
legs, pathologic fractures, hypocalcemic
tetany, hypocalcemic convulsions,
Harrison’s sulcus.
Radiological evidence from wrist included 2
or more of following: generalized
osteopenia, fraying & cupping of distal
ends of radius or ulna.
All treated with intramuscular
single dose of vitamin D3 (7500 µg)
and oral dose of Ca (50 mg/kg/d for
10 days).
Pre treatment
25(OH)D: 10.5 (4.6)
Ca: 58.2 (5.9)
Post treatment
25(OH)D: 131.8 (44.1)
Ca: 99.5 (6.4)
Calcium intakes/
other comments
Ca intakes not
reported
Thacher et al
(2009)
Jos, Nigeria.
Prepubertal children (n=17)
with clinical signs of rickets.
Mean age(range):44.5 m (28–
118)
Subjects required radiological score of at
least 1.5 on a previously validated 10-point
scale for assessing severity of childhood
rickets (Thacher et al, 2000)
Maize porridge (150ml) & orange
juice (50ml) with added Ca (120 mg
calcium glubionate & 20g calcium
chloride).
After drawing blood, 0.5 mg Ca
infused slowly.
Baseline:
25(OH)D: 50 (12.5–80)
Ca: 88 ± 10
Ca intakes (mg):
182 (73)
After 4 days, single oral dose of
vitamin D2 or D3 (1250 µg).
Cesur et al (2011)
Van, Turkey
Retrospective study of
medical records of patients
(n=946) with nutritional
rickets (25(OH)D