Vitamin D and Health

Table 9: Cohort studies on association between maternal 25(OH)D concentration and bone health indices in the offspring
Author/Year Population Design Mean maternal 25(OH)D
concentration (nmol/L)
Mean cord 25(OH)D
concentration (nmol/L)
Findings
Mahon et al (2010)
Southampton, UK
Pregnant women (n=424)
Mean age: 31.3 (3.6)y
Longitudinal
At 34 wks:
Median: 31.3 (IQR: 41-85)
5.9% < 25
30.7% < 50
Not measured
Infants born to mothers with 25(OH)D
concentration < 50 nmol/L had increased
femoral splaying indices compared with > 50
nmol/L.
Prentice et al (2009)
The Gambia, Africa
Pregnant women (n=125)
and their infants
Mean age: 27.4 (7.5)y
Original Ca RCT.
Cross-sectional
with longitudinal
follow up
At 20 wks: 103 (25)
At 36 wks: 111 (27)
Not measured
No relationship between maternal 25(OH)D
concentrations and BMC/BMD of radius and
whole body in infants.
Viljakainen et al (2010)
Helsinki, Finland
Pregnant women (n=125)
Mean age:31 (4) y
Cross-sectional and
longitudinal
1 st trimester: 41 (13.6)
Postpartum: 45.1 (11.9)
50.7 (14.9) Median 25(OH)D concentration (42.6 nmol/L)
used as cut off. Tibia BMC of infants born to
mothers above the median was 0.047g/cm
higher than those born to below median
group but there was no difference in BMD.
Young et al (2012)
Baltimore, USA
171 Pregnant adolescent
girls (n=171) and their
infants
Longitudinal follow
up
26 weeks gestation and at delivery:
54.7 (27.5)
Not measured.
Maternal 25(OH)D > 50 nmol/L significantly
positively associated with fetal femur and
humerus z scores. (p < 0.01).
Age: