Myeloid Leukemia

FLT3 Mutations in AML 197
10. Kiyoi, H., Naoe, T., Nakano, Y., et al. (1999) Prognostic implication of FLT3 and
N-RAS gene mutations in acute myeloid leukemia. Blood 93, 3074–3080.
11. Kottaridis, P. D., Gale, R. E., Frew, M. E., et al. (2001) The presence of a FLT3
internal tandem duplication in patients with acute myeloid leukemia (AML) adds
important prognostic information to cytogenetic risk group and response to the
first cycle of chemotherapy: analysis of 854 patients from the United Kingdom
Medical Research Council AML 10 and 12 trials. Blood 98, 1752–1759.
12. Kiyoi, H., Towatari, M., Yokota, S., et al. (1998) Internal tandem duplication of
the FLT3 gene is a novel modality of elongation mutation which causes constitutive
activation of the product. Leukemia 12, 1333–1337.
13. Bianchini, M., Ottaviani, E., Grafone, T., et al. (2003) Rapid detection of Flt3
mutations in acute myeloid leukemia patients by denaturing HPLC. Clin. Chem.
49, 1642–1650.
14. Taketani, T., Taki, T., Sugita, K., et al. (2004) FLT3 mutations in the activation
loop of tyrosine kinase domain are frequently found in infant ALL with MLL
rearrangements and pediatric ALL with hyperdiploidy. Blood 103, 1085–1088.
15. Stirewalt, D. L., Kopecky, K. J., Meshinchi, S., et al. (2001) FLT3, RAS, and
TP53 mutations in elderly patients with acute myeloid leukemia. Blood 97, 3589–
3595.
16. Whitman, S. P., Archer, K. J., Feng, L., et al. (2001) Absence of the wild-type
allele predicts poor prognosis in adult de novo acute myeloid leukemia with normal
cytogenetics and the internal tandem duplication of FLT3: a cancer and leukemia
group B study. Cancer Res. 61, 7233–7239.