John M. S. Bartlett.pdf - Bio-Nica.info

292 Edwards and Bartlett
Stepwise mutation models and microsatellite polymorphisms have been used to
determine relationships among primates (19). Such studies have investigated the
relationship between humans, chimpanzees, and gorillas (19). There is also an ongoing
debate about proper interpretation of DNA sequence polymorphisms and their ability
to reconstruct human population history (20).
Mutational analysis is also used in genotyping. It was use of mutational analysis
that demonstrated that birds are not monogamous because genotyping performed on
eggs in the same nest demonstrated different parentage (21). Genotyping is also used
when breeding animals in captivity to determine their most appropriate mate (21).
In summary, polymorphism and mutational analysis is a major tool in science today,
without which much of our current understanding of genetics would not have been
possible.
References
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R. P., et al. (1999) Microsatellite instability and loss of heterozygosity in prostatic
carcinomas: comparison of primary tumours, and of corresponding recurrences after
androgen-deprivation therapy and lymph node metastases. Prostate 40, 20–27.
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M. W. (1997) Patterns of Allelic loss on chromosome 17 in sporadic breast carcinomas
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Detection of microsatellite instability and loss of heterozygosity in colorectal tumours by
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