rok 2006 - Fakulta chemickej a potravinárskej technológie ...

APVV project LPP-0238-06 Asymmetric synthesis based on a template for crystallizationinduced
asymmetric transformation (CIAT) (Lubor Fišera)
Detailed information on application of acylacrylic subunit as a template for crystallization-induced asymmetric
transformation (CIAT). Marking out the boundaiy for effective asymmetric synthesis by this method. Acquisition of
information essential for next shift from acylacrylic template towards crystallization auxiliaries, making accessible
future synthetic options. Simplification of existing synthetic procedures leading to chiral amino and hydroxyamino
acids, respectively. 1.3-DCA of prepared alkenes with subsequent transformation to corresponding aminohydroxy
acids and derivatives. Utilization of prepared chiral hydroxyamino acids in synthesis of selected target compounds
containing piperidine or pyrrolidine skeleton.
Project duration: from 01.12.2006 to 30.11.2009
APVV project No 20-000305 New strategies for stereoselective and asymmetric syntheses of
biologically active natural compounds (Tibor Gracza)
Development of the new stereoselective and asymmetric strategies for funcionalization of C=C double bond of
alkenes with introduction of O- and/or N-functions. Asymmetric Pd(II)-catalyzed oxy-/aminocarbonylations of
unsaturated polyols and amino polyols. Catalyst design using X-ray and electron density analysis and QM
method. Theoretical calculations of TS-models for prediction of stereochemical outcome (ee%) of the reactions.
Their application in the syntheses of natural compounds and biologically interesting compounds. Stereoselective
synthesis of optically active polysubstituted pyrrolidin-2-ones and piperidin-2-ones from chiral g-aminoacids -
precursors for preparation of polyhydroxylated pyrrolidines, piperidines, pyrrolizidines and indolizines. The
synthesis of non-proteinogenic amino acids derived nitrones, isoxazolidinyl nucleosides, spironucleosides and
azanucleosides. The study of the effect of Lewis acids to influence diastereoselectivity of nitrone cycloaddition
reactions.
Project duration: from 01.03.2006 to 28.02.2009
VEGA project No 1/2456/05 Stereoselective Syntheses of Chiral 1,4-Dihydropyridines and
Analogs of Indolizine type Alkaloids (Štefan Marchalín)
The principal goal of the project is to investigate posible utilization of 2-formyl- dihydropyridines in the synthesis of
novel chiral nonracemic 2-substituted dihydropyridines, bi- and tricyclic heterocycles respectively, containing a
1,4-dihydropyridine ring. Preparation and characterrization of coordination compounds of both transition and non
transition metals carrying 1,4-dihydropyridine based ligands, examination of their composition, structure, and
investigation of their catalytic activity. The project aims at preparation of carefully designed substituted indolizines
and indolizidines - compounds with possible bioactivity. Practical application of regio-, chemo- and stereoselective
reactions making use of novel features of organic synthesis. Elaboration of novel, simple, and generally
applicable stereocontrolled syntheses of pure analogs of indolizine type alkaloids, utilizing chiral synthons based
on hetero[f]indolizidinediones.
Project duration: from 01. 01. 2005 to 31.12.2007
VEGA project No 1/1379/04 Syntheses directed towards novel heterocyclic compounds such
that show opto-electronic properties, specific bioactivity, and apoptosis (Daniel Végh)
Design of syntheses of novel compounds supported by modern trends gleaned from theoretical studies. Synthesis
of novel heterocyclic compounds from the furan, thiophene, pyrrole, imidazole, pyrazine, pyrone series a
modeling of their biological activity. Study of controlled di- and trimerization of the prepared conjugated
heterocyclic compounds aiming at preparation of molecular and supramolecular functional units and nanostructures.
Modeling of supramolecular structures and potential conjugated antennae systems for molecular
recognition and self-organization by theoretical calculations a combination of building blocks. Utilization of
perfluoroaromatics for molecular recognition. Structure modeling of compounds with cancerostatic effects and
those capable of initiating apoptosis.
Project duration: from 01.01.2004 to 31.12.2006
VEGA project No 1/2469/05 Study of stereoselective transformations of non proteinogenic
oxoaminocarboxylic acids (Dušan Berkeš)
Synthesis of enantiomerically pure, conformationally restricted derivatives of homophenylalanine and of its
heteroanalogs by crystallization induced asymmetric transformation (CIAT) coupled with the aza-Michael addition
and electrophilic lactonization. Study of simultaneous CIAT taking place at two stereogenic centers. Synthesis
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